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Endometrial injury for patients with endometriosis and polycystic ovary syndrome undergoing medically assisted reproduction: current data and a protocol

  • Charalampos Siristatidis EMAIL logo , Ioannis Rigos , Vasilios Pergialiotis , Vasilios Karageorgiou , Nikolaos Christoforidis , George Daskalakis , Stefano Bettocchi and Antonis Makrigiannakis
Published/Copyright: August 25, 2018

Abstract

We propose a study protocol capable of improving clinical outcomes following medically assisted reproduction (MAR) in infertile women with endometriosis and polycystic ovary syndrome (PCOS). The proposed research derives from the published evidence on the positive impact from endometrial injury (EI) and the beneficial nature of the intervention towards improved implantation rates. We primarily refer to the cluster of events and hypotheses, such as the mechanical cascade, the inflammatory response per se, the events accompanying wound healing, the immune cell recruitment and protein involvement, alterations in gene expression and the neo-angiogenesis theories, which have been previously investigated for this purpose. We are also exploring the possible problems in MAR cycles with negative outcomes in PCOS and endometriosis patients and we are proposing potential mechanisms on how this intervention might work. Our hypothesis states that the EI before the initiation of the MAR cycle can affect clinical pregnancy rates in patients with the aforementioned pathologies.

Author Statement

  1. Research funding: The authors state no funding involved.

  2. Conflict of interest: The authors declare no conflict of interest.

  3. Informed consent: Written informed consent will be obtained before the enrollment of the participants.

  4. Ethical approval: Approval will be obtained from the Scientific and Ethics Comittees of the Attikon University Hospital (the Hospital of the first author).

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Received: 2018-06-03
Accepted: 2018-07-11
Published Online: 2018-08-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

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