Startseite Immune-regulatory activity of methanolic extract of Acacia confusa heartwood and melanoxetin isolated from the extract
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Immune-regulatory activity of methanolic extract of Acacia confusa heartwood and melanoxetin isolated from the extract

  • Shang-Tse Ho , Yu-Tang Tung , Yu-Jung Wu , Chi-Chen Lin EMAIL logo und Jyh-Horng Wu EMAIL logo
Veröffentlicht/Copyright: 22. November 2014
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Holzforschung
Aus der Zeitschrift Holzforschung Band 69 Heft 5

Abstract

The antioxidant, anti-inflammatory, antivirus, uric acid decreasing, and hepatoprotective activities of Acaciaconfusa extracts were demonstrated in previous studies. However, there is no scientific evidence concerning the immune-regulatory activity of the heartwood extract of A. confusa. In this study, the effect of a methanolic heartwood extract (MHE) from A. confusa on dendritic cell (DC) activation and function was examined. A. confusa MHE significantly reduced the production of pro-inflammatory cytokine interleukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated DCs, and the effective concentration (25 μg ml-1) of A. confusa MHE did not affect cell viability. Additionally, the bioactive phytochemical from A. confusa MHE, melanoxetin, was isolated and purified by HPLC. This substance inhibited the production of pro-inflammatory cytokines (tumor necrosis factor-α, IL-6, and IL-12) in LPS-stimulated DC at a concentration of 12.5 μM. Moreover, the expression levels of co-stimulatory molecules such as CD40, CD80, and CD86 also remarkably decreased after treatment with melanoxetin at the same dose. These findings indicate that A. confusa MHE and melanoxetin have excellent immune-suppressive activity and may be potential candidates for further development of natural health supplements.

Keywords: Acacia confusa; dendritic cell; heartwood; immune-regulatory activity; melanoxetin
Corresponding authors: Chi-Chen Lin, Institute of Biomedical Science, National Chung Hsing University, Taichung 402, Taiwan, Tel.: +886 4 22840345, Fax: +886 4 22851308, e-mail: ; and Jyh-Horng Wu, Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan, Tel.: +886 4 22840345, Fax: +886 4 22851308, e-mail:

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Received: 2014-7-16
Accepted: 2014-10-23
Published Online: 2014-11-22
Published in Print: 2015-7-1

©2015 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Study on the residual lignin in Eucalyptus globulus sulphite pulp
  4. Hydrogenolysis of lignin in ZnCl2 and KCl as an inorganic molten salt medium
  5. Synthesis of lignin polyols via oxyalkylation with propylene carbonate
  6. Preparation of water-dispersive poly(3,4-ethylenedioxythiophene) (PEDOT) conductive nanoparticles in lignosulfonic acid solution
  7. Properties of polyurethane (PUR) films prepared from liquefied wood (LW) and ethylene glycol (EG)
  8. Dynamic response of earlywood and latewood within annual growth ring structure of Scots pine subjected to changing relative humidity
  9. One-stage thermo-hydro treatment (THT) of hardwoods: an analysis of form stability after five soaking-drying cycles
  10. The variation of tangential rheological properties caused by shrinkage anisotropy and moisture content gradient in white birch disks
  11. Inheritance of basic density and microfibril angle and their variations among full-sib families and their parental clones in Picea glehnii
  12. Mechanical properties and chemical composition of beech wood exposed for 30 and 120 days to white-rot fungi
  13. Chemical improvement of surfaces. Part 3: Covalent modification of Scots pine sapwood with substituted benzoates providing resistance to Aureobasidium pullulans staining fungi
  14. Chemical and ultrastructural changes of ash wood thermally modified using the thermo-vacuum process: I. Histo/cytochemical studies on changes in the structure and lignin chemistry
  15. Chemical and ultrastructural changes of ash wood thermally modified (TMW) using the thermo-vacuum process: II. Immunocytochemical study of the distribution of noncellulosic polysaccharides
  16. Revisiting hardboard properties from the fiber sorting point of view
  17. Effects of acetylation and formalization on the dynamic water vapor sorption behavior of wood
  18. Immune-regulatory activity of methanolic extract of Acacia confusa heartwood and melanoxetin isolated from the extract
  19. Stereomicroscopic optical method for the assessment of load transfer patterns across the wood-adhesive bond interphase
https://doi.org/10.1515/hf-2014-0208
Schlagwörter für diesen Artikel
Acacia confusa; dendritic cell; heartwood; immune-regulatory activity; melanoxetin

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Study on the residual lignin in Eucalyptus globulus sulphite pulp
  4. Hydrogenolysis of lignin in ZnCl2 and KCl as an inorganic molten salt medium
  5. Synthesis of lignin polyols via oxyalkylation with propylene carbonate
  6. Preparation of water-dispersive poly(3,4-ethylenedioxythiophene) (PEDOT) conductive nanoparticles in lignosulfonic acid solution
  7. Properties of polyurethane (PUR) films prepared from liquefied wood (LW) and ethylene glycol (EG)
  8. Dynamic response of earlywood and latewood within annual growth ring structure of Scots pine subjected to changing relative humidity
  9. One-stage thermo-hydro treatment (THT) of hardwoods: an analysis of form stability after five soaking-drying cycles
  10. The variation of tangential rheological properties caused by shrinkage anisotropy and moisture content gradient in white birch disks
  11. Inheritance of basic density and microfibril angle and their variations among full-sib families and their parental clones in Picea glehnii
  12. Mechanical properties and chemical composition of beech wood exposed for 30 and 120 days to white-rot fungi
  13. Chemical improvement of surfaces. Part 3: Covalent modification of Scots pine sapwood with substituted benzoates providing resistance to Aureobasidium pullulans staining fungi
  14. Chemical and ultrastructural changes of ash wood thermally modified using the thermo-vacuum process: I. Histo/cytochemical studies on changes in the structure and lignin chemistry
  15. Chemical and ultrastructural changes of ash wood thermally modified (TMW) using the thermo-vacuum process: II. Immunocytochemical study of the distribution of noncellulosic polysaccharides
  16. Revisiting hardboard properties from the fiber sorting point of view
  17. Effects of acetylation and formalization on the dynamic water vapor sorption behavior of wood
  18. Immune-regulatory activity of methanolic extract of Acacia confusa heartwood and melanoxetin isolated from the extract
  19. Stereomicroscopic optical method for the assessment of load transfer patterns across the wood-adhesive bond interphase
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