A potentially versatile nano-platform
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Yun-Sang Lee
Yun-Sang Lee is the Brain Korea 21 plus (BK21 plus) Associate Professor in the Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology at Seoul National University. He received his BS and MS from the Department of Chemistry, College of Sciences at Kyunghee University, Korea in 1996 and 1998, and his PhD from the Department of Pharmaceutical Manufacturing Chemistry, College of Pharmacy at Seoul National University, Korea in 2006, respectively. He is interest in the field of development and implementation of new methods for radiolabeling chemistry and development of new diagnostic or therapeutic radiopharmaceutical, and also, development of new method for the surface modification or radiolabeling of nano-materials, especially radionanomedicine, and their uses for diagnosis/therapy or theragnosis.
Jae Min Jeong is a radiopharmaceutical chemist in the Department of Nuclear Medicine in Seoul National University College of Medicine. He graduated from the College of Pharmacy, Seoul National University in 1982. He obtained his MS and PhD degrees at the same university. He studied radiolabeling of antibodies for nuclear imaging and therapy as a Post-Doc at the National Institutes of Health in USA. He became a faculty member at the Seoul National University College of Medicine in 1994. He developed various radiopharmaceuticals labeled with Re-188, Tc-99m, Ga-68, F-18, and C-11. He has published more than 130 peer-reviewed papers in well-known international journals, and has registered over 20 patents.
Abstract
Radionanomedicine is the medical field which uses radioisotope labeled nanomaterials for diagnostic, therapeutic or theranostic purposes. An amphiphile- encapsulation method has been developed to hydrophilize nanoparticles and the introduction of multifunctional ligands. A copper-free click chemistry has been applied for introduction of various ligands to the nanoparticles. The combination of the amphiphile-encapsulation method and click chemistry might provide a versatile nano-platform to radionanomedicine, which might contribute to the earlier clinical application of radionanomedicine for theragnosis of various diseases.
Funding source: National Research Foundation of Korea
Award Identifier / Grant number: NRF-2013R1A2A1A05006227
Award Identifier / Grant number: 1711026888
Funding statement: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. NRF-2013R1A2A1A05006227 and 1711026888).
About the authors
Yun-Sang Lee is the Brain Korea 21 plus (BK21 plus) Associate Professor in the Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology at Seoul National University. He received his BS and MS from the Department of Chemistry, College of Sciences at Kyunghee University, Korea in 1996 and 1998, and his PhD from the Department of Pharmaceutical Manufacturing Chemistry, College of Pharmacy at Seoul National University, Korea in 2006, respectively. He is interest in the field of development and implementation of new methods for radiolabeling chemistry and development of new diagnostic or therapeutic radiopharmaceutical, and also, development of new method for the surface modification or radiolabeling of nano-materials, especially radionanomedicine, and their uses for diagnosis/therapy or theragnosis.
Jae Min Jeong is a radiopharmaceutical chemist in the Department of Nuclear Medicine in Seoul National University College of Medicine. He graduated from the College of Pharmacy, Seoul National University in 1982. He obtained his MS and PhD degrees at the same university. He studied radiolabeling of antibodies for nuclear imaging and therapy as a Post-Doc at the National Institutes of Health in USA. He became a faculty member at the Seoul National University College of Medicine in 1994. He developed various radiopharmaceuticals labeled with Re-188, Tc-99m, Ga-68, F-18, and C-11. He has published more than 130 peer-reviewed papers in well-known international journals, and has registered over 20 patents.
Acknowledgments:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. NRF-2013R1A2A1A05006227 and 1711026888).
Conflict of interest statement: Authors state no conflict of interest. All authors have read the Journal’s publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.
References
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- In this issue
- What’s Up?
- What’s up in nanomedicine?
- Special section Radionanomedicine
- Guest Editorial
- Radionanomedicine
- Review
- Translational radionanomedicine: a clinical perspective
- Perspective
- A potentially versatile nano-platform
- Regular contributions
- Original Articles
- Preparation and characterization of nanoparticles composed of methylated N-(4-N,N-dimethyl aminobenzyl) chitosan for oral delivery of cyclosporine A
- Formulation of gentamicin as surface modified self-nanoemulsifying formulations (SNEFs) improves its anti-pneumococcal activity
Artikel in diesem Heft
- Frontmatter
- In this issue
- What’s Up?
- What’s up in nanomedicine?
- Special section Radionanomedicine
- Guest Editorial
- Radionanomedicine
- Review
- Translational radionanomedicine: a clinical perspective
- Perspective
- A potentially versatile nano-platform
- Regular contributions
- Original Articles
- Preparation and characterization of nanoparticles composed of methylated N-(4-N,N-dimethyl aminobenzyl) chitosan for oral delivery of cyclosporine A
- Formulation of gentamicin as surface modified self-nanoemulsifying formulations (SNEFs) improves its anti-pneumococcal activity
