Tailoring surface nanostructures on polyaryletherketones for load-bearing implants
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Prabitha Urwyler
Prabitha Urwyler received her Bachelor of Technology (B.Tech) in Computer Engineering from the Mangalore University, India in 1995. She worked as a software engineer at Melstar Information Technologies Ltd, India from 1995 to 1997 and later at the Swiss News Agency (SDA – ATS), Switzerland until 2008. She received her M.Sc in Biomedical Engineering from the University of Bern in 2008. In 2012, she completed her PhD degree in Biomedical Engineering on the fabrication, characterization and application of disposable micro-cantilevers for biomedical applications at the University of Basel and the Paul Scherrer Institut. She worked as a Postdoc at the Biomaterials Science Center, University of Basel from 2012 to 2013. She is currently working as a Postdocoral researcher at the Gerontechnology and Rehabilitation group, University of Bern.
Xue Zhao studied physics in a joined Bachelor program of Wuhan University (China) and University Claude Bernard Lyon 1 (France), and received her BSc in Physics in 2010. She continued her studies in the department of physics at ETH Zürich, where she obtained her MSc in Physics in 2013. During this time she worked as intern at Paul Scherrer Institute and research assistant at University of Basel. Currently she is working towards her PhD in Experimental Physics on magnetism of coupled ferromagnetic and rare-earth ferromagnetic thin films at University of Basel and EMPA Dübendorf.
Alfons Pascual received his PhD in Organic Chemistry at the Sarriàs Chemical Institute (IQS, Barcelona University) in 1981 and worked on post-doc positions at the ETH in Zürich (Switzerland) and at the Max-Planck Institute in Mülheim a.d. Ruhr (Germany). From 1986 to 2000 he worked as laboratory head and project leader on design of insecticidal active compounds at Ciba-Geigy (from 1996 on Novartis) in Basel, Switzerland. Then he joined the University of Applied Sciences of Northwestern Switzerland (FHNW) as head of Polymer Analytics within the Institute of Polymer Engineering (IKT). He is strongly involved in failure analysis in polymeric materials.
Helmut Schift received his diploma in Electrical Engineering from the University of Karlsruhe, Germany. He performed his PhD studies at the Institute of Microtechnology Mainz (IMM), Germany. After his graduation in 1994, he joined PSI as a research staff member and is now head of the INKA-PSI Group in the Laboratory for Micro- and Nanotechnology at the PSI. He is actively involved in the development of nanoimprint lithography (NIL) as an alternative nanopatterning method for device fabrication. He is currently working in various national and international projects on stamp fabrication, hybrid technologies and innovative 3-D nanomolding.
Bert Müller received a diploma in mechanical engineering (1982), followed by the MSc degree from the Dresden University of Technology and the PhD from the University of Hannover, Germany in 1989 and 1994. From 1994 to 2001, he worked as a researcher at the Paderborn University, Germany, EPF Lausanne, ETH Zurich. He became a faculty member of the Physics Department at ETH Zurich in April 2001. After his election as Thomas Straumann-Chair for Materials Science in Medicine at the University of Basel, Switzerland and his appointment at the Surgery Department of the University Hospital Basel in September 2006, he founded the Biomaterials Science Center. He also teaches physics and materials science at the ETH Zurich and the University of Basel.
Abstract
High-performance thermoplastics including polyetheretherketone (PEEK) are key biomaterials for load-bearing implants. Plasma treatment of implants surfaces has been shown to chemically activate its surface, which is a prerequisite to achieve proper cell attachment. Oxygen plasma treatment of PEEK films results in very reproducible surface nanostructures and has been reported in the literature. Our goal is to apply the plasma treatment to another promising polymer, polyetherketoneketone (PEKK), and compare its characteristics to the ones of PEEK. Oxygen plasma treatments of plasma powers between 25 and 150 W were applied on 60 μm-thick PEKK and 100 μm-thick PEEK films. Analysis of the nanostructures by atomic force microscopy showed that the roughness increased and island density decreased with plasma power for both PEKK and PEEK films correlating with contact angle values without affecting bulk properties of the used films. Thermal analysis of the plasma-treated films shows that the plasma treatment does not change the bulk properties of the PEKK and PEEK films.
About the authors
Prabitha Urwyler received her Bachelor of Technology (B.Tech) in Computer Engineering from the Mangalore University, India in 1995. She worked as a software engineer at Melstar Information Technologies Ltd, India from 1995 to 1997 and later at the Swiss News Agency (SDA – ATS), Switzerland until 2008. She received her M.Sc in Biomedical Engineering from the University of Bern in 2008. In 2012, she completed her PhD degree in Biomedical Engineering on the fabrication, characterization and application of disposable micro-cantilevers for biomedical applications at the University of Basel and the Paul Scherrer Institut. She worked as a Postdoc at the Biomaterials Science Center, University of Basel from 2012 to 2013. She is currently working as a Postdocoral researcher at the Gerontechnology and Rehabilitation group, University of Bern.
Xue Zhao studied physics in a joined Bachelor program of Wuhan University (China) and University Claude Bernard Lyon 1 (France), and received her BSc in Physics in 2010. She continued her studies in the department of physics at ETH Zürich, where she obtained her MSc in Physics in 2013. During this time she worked as intern at Paul Scherrer Institute and research assistant at University of Basel. Currently she is working towards her PhD in Experimental Physics on magnetism of coupled ferromagnetic and rare-earth ferromagnetic thin films at University of Basel and EMPA Dübendorf.
Alfons Pascual received his PhD in Organic Chemistry at the Sarriàs Chemical Institute (IQS, Barcelona University) in 1981 and worked on post-doc positions at the ETH in Zürich (Switzerland) and at the Max-Planck Institute in Mülheim a.d. Ruhr (Germany). From 1986 to 2000 he worked as laboratory head and project leader on design of insecticidal active compounds at Ciba-Geigy (from 1996 on Novartis) in Basel, Switzerland. Then he joined the University of Applied Sciences of Northwestern Switzerland (FHNW) as head of Polymer Analytics within the Institute of Polymer Engineering (IKT). He is strongly involved in failure analysis in polymeric materials.
Helmut Schift received his diploma in Electrical Engineering from the University of Karlsruhe, Germany. He performed his PhD studies at the Institute of Microtechnology Mainz (IMM), Germany. After his graduation in 1994, he joined PSI as a research staff member and is now head of the INKA-PSI Group in the Laboratory for Micro- and Nanotechnology at the PSI. He is actively involved in the development of nanoimprint lithography (NIL) as an alternative nanopatterning method for device fabrication. He is currently working in various national and international projects on stamp fabrication, hybrid technologies and innovative 3-D nanomolding.
Bert Müller received a diploma in mechanical engineering (1982), followed by the MSc degree from the Dresden University of Technology and the PhD from the University of Hannover, Germany in 1989 and 1994. From 1994 to 2001, he worked as a researcher at the Paderborn University, Germany, EPF Lausanne, ETH Zurich. He became a faculty member of the Physics Department at ETH Zurich in April 2001. After his election as Thomas Straumann-Chair for Materials Science in Medicine at the University of Basel, Switzerland and his appointment at the Surgery Department of the University Hospital Basel in September 2006, he founded the Biomaterials Science Center. He also teaches physics and materials science at the ETH Zurich and the University of Basel.
Acknowledgments
We thank Christian Spreu (PSI) for providing the SEM images, Konrad Vogelsang (PSI) for support with knowledge about hot embossing, Rolf Schelldorfer (PSI) for the assistance during the AFM measurements and Prof. Dr. Uwe Pieles (FHNW) for providing the contact angle instrument. We express our gratitude to Oxford Performance Materials and Victrex for supplying us with OXPEKK PEKK and APTIV™ PEEK films. Partial financial support was provided by grants from the Swiss Nanoscience Institute (SNI) and the Swiss Academy of Engineering Sciences (SATW).
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Artikel in diesem Heft
- Cover and Frontmatter
- Notice from the Editorial Office
- News from the European Foundation for Nanomedicine (CLINAM)
- What’s up in nanomedicine?
- Introducing our Cover Contest Winner
- Living immune cells as drug carriers in cancer therapy
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- Original Articles
- Measurement of the size and charge distribution of sodium chloride particles generated by an Aeroneb Pro® pharmaceutical nebulizer
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Artikel in diesem Heft
- Cover and Frontmatter
- Notice from the Editorial Office
- News from the European Foundation for Nanomedicine (CLINAM)
- What’s up in nanomedicine?
- Introducing our Cover Contest Winner
- Living immune cells as drug carriers in cancer therapy
- Critical Review
- Towards nano-diagnostics for rapid diagnosis of infectious diseases – current technological state
- Original Articles
- Measurement of the size and charge distribution of sodium chloride particles generated by an Aeroneb Pro® pharmaceutical nebulizer
- Tailoring surface nanostructures on polyaryletherketones for load-bearing implants
- Opinion paper: Meeting report
- Nanomedicine: visions, risk, potential
- Corrigendum
- Nanoemulsions: increasing possibilities in drug delivery
