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Diagnostic accuracy of non-mydriatic fundus photography as a triage and telemedicine tool for patients with vision loss

  • Chijindu A. Ukagwu ORCID logo EMAIL logo , Joshua C. Teichman , Amandeep S. Rai , Amrit S. Rai , Gary L. Yau , Michelle Khan and Rahul A. Sharma
Published/Copyright: February 20, 2025

Abstract

Objectives

Fundoscopy can be challenging for non-ophthalmologists. For emergency physicians, non-mydriatic fundus photography is superior to other forms of ophthalmoscopy in sensitivity, specificity, and inter-examination agreement. We report on a prospective cross-sectional study evaluating the use of non-mydriatic photography as a triage and telemedicine tool for patients with vision loss in a Canadian emergency setting.

Methods

Images of both eyes were obtained by a non-ophthalmologist using a handheld, non-mydriatic fundus camera and shared with a fellowship-trained ophthalmologist without patient context. The reviewer was asked to (1) select the best photo obtained for each eye and rate image quality on a Likert scale, (2) comment on the presence or absence of fundus abnormalities and (3) provide an opinion on whether findings would have changed patient disposition if available at the time of the initial Emergency Department (ED) exam.

Results

Of 57 patients evaluated in the ED for vision loss, 22.8 % had a documented fundus examination. 86.8 % of images were deemed to have acceptable quality (Likert scale≥2). Factors limiting image quality included media opacity, pupillary miosis, photosensitivity, and eyelid/periorbital abnormalities. Of patients with relevant abnormalities, 0 % were identified by emergency physicians. In contrast, 37.5 % of patients with relevant findings were identified on review of images alone (specificity=100 %).

Conclusions

Fundoscopy is infrequently performed in the emergency setting in patients presenting with vision loss. Non-mydriatic fundus photography is a cost-effective method of fundus examination for non-expert examiners and can be reliably used as a telemedicine tool for remote ophthalmology consultation.


Corresponding author: Chijindu A. Ukagwu, Temerty Faculty of Medicine, University of Toronto, King’s College Circle Medical Sciences Building, Room 2109, Toronto, ON M5S 1A8, Canada, E-mail:

  1. Research ethics: Ethics approval was obtained from the research ethics board at the academically affiliated tertiary care center at which the study was conducted on June 14, 2023. The document ID was ID#1156. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).

  2. Informed consent: Informed consent was obtained from all individuals included in this study.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: None declared.

  7. Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

1. Bruce, BB, Thulasi, P, Fraser, CL, Keadey, MT, Ward, A, Heilpern, KL, et al.. Diagnostic accuracy and use of nonmydriatic ocular fundus photography by emergency physicians: phase II of the FOTO-ED study. Ann Emerg Med 2013;62:28–33.e1. https://doi.org/10.1016/j.annemergmed.2013.01.010. Epub 2013 Feb 21. PMID: 23433654; PMCID: PMC3722897.Search in Google Scholar PubMed PubMed Central

2. Bruce, BB, Lamirel, C, Wright, DW, Ward, A, Heilpern, KL, Biousse, V, et al.. Nonmydriatic ocular fundus photography in the emergency department. N Engl J Med 2011;364:387–9. https://doi.org/10.1056/NEJMc1009733. PMID: 21268749; PMCID: PMC3433395.Search in Google Scholar PubMed PubMed Central

3. Dunn, HP, Marks, S, Teo, KZ, Dunn, SM, Healey, PR, White, AJ. eFOCUS 2: a randomised crossover trial of smartphone fundoscopy and direct ophthalmoscopy aiming to improve optic disc interpretation by medical students with e‐learning support. Clin Exp Ophthalmol 2021;49:704–13. https://doi.org/10.1111/ceo.13977.Search in Google Scholar PubMed

4. Bruce, BB, Lamirel, C, Biousse, V, Ward, A, Heilpern, KL, Newman, NJ, et al.. Feasibility of nonmydriatic ocular fundus photography in the emergency department: phase I of the FOTO-ED study. Acad Emerg Med 2011;18:928–33. https://doi.org/10.1111/j.1553-2712.2011.01147.x.Search in Google Scholar PubMed PubMed Central

5. Ukagwu, C, Teichman, J, Ben-Yakov, M, Dubinsky, I, Théogène, A, Sharma, R. Emergency department ophthalmoscopy: physician confidence and clinical practices. Can J Emerg Med 2025. https://doi.org/10.1007/s43678-024-00843-9.Search in Google Scholar PubMed

6. McGinnity, K, William, M. Direct ophthalmoscopy… soon to be forgotten? Ulst Med J 2019;88:115–17.Search in Google Scholar

7. Wolfs, RC, Grobbee, DE, Hofman, A, de Jong, PT. Risk of acute angle-closure glaucoma after diagnostic mydriasis in nonselected subjects: the Rotterdam Study. Investig Ophthalmol Vis Sci 1997;38:2683–7. PMID: 9375589.Search in Google Scholar

8. Stavert, B, McGuinness, MB, Harper, CA, Guymer, RH, Finger, RP. Cardiovascular adverse effects of phenylephrine eyedrops: a systematic review and meta-analysis. JAMA Ophthalmol 2015;133:647–52. https://doi.org/10.1001/jamaophthalmol.2015.0325. PMID: 25789577.Search in Google Scholar PubMed

9. Arslan-Carlon, V, Walline, MC, Seier, K, Tan, KS, Abramson, DH. Hemodynamic changes associated with mydriatic eye drop administration in anesthetized pediatric patients. Ocul Oncol Pathol 2020;6:203–9. https://doi.org/10.1159/000500593. Epub 2019 Oct 30. PMID: 32509766; PMCID: PMC7250338.Search in Google Scholar PubMed PubMed Central

10. Kozner, P, Eichenmann, L, Ceska Burdova, M, Pavlikova, M, Hlozanek, M, Dotrelova, D. Long-term outcomes of intravenous fibrinolysis in central retinal artery occlusion. Sci Rep 2023;13:20505. https://doi.org/10.1038/s41598-023-47987-9. PMID: 37993533; PMCID: PMC10665428.Search in Google Scholar PubMed PubMed Central

11. Rigi, M, Almarzouqi, S, Morgan, M, Lee, A. Papilledema: epidemiology, etiology, and clinical management. Eye Brain 2015;7:47–57. https://doi.org/10.2147/EB.S69174.Search in Google Scholar PubMed PubMed Central

12. Roberts, E, Morgan, R, King, D, Clerkin, L. Fundoscopy: a forgotten art? Postgrad Med J 1999;75:282–4. https://doi.org/10.1136/pgmj.75.883.282. PMID: 10533632; PMCID: PMC1741240.Search in Google Scholar PubMed PubMed Central

13. Bruce, BB, Newman, NJ, Pérez, MA, Biousse, V. Non-mydriatic ocular fundus photography and telemedicine: past, present, and future. Neuroophthalmology 2013;37:51–7. https://doi.org/10.3109/01658107.2013.773451.Search in Google Scholar PubMed PubMed Central

14. Diamond, JP, McKinnon, M, Barry, C, Geary, D, McAllister, IL, House, P, et al.. Non-mydriatic fundus photography: a viable alternative to fundoscopy for identification of diabetic retinopathy in an Aboriginal population in rural Western Australia? Aust N Z J Ophthalmol 1998;26:109–15. https://doi.org/10.1111/j.1442-9071.1998.tb01525.x. PMID: 9630290.Search in Google Scholar PubMed

15. Sothivannan, A, Eshtiaghi, A, Dhoot, AS, Popovic, MM, Garg, SJ, Kertes, PJ, et al.. Impact of the time to surgery on visual outcomes for rhegmatogenous retinal detachment repair: a meta-analysis. Am J Ophthalmol 2022;244:19–29. https://doi.org/10.1016/j.ajo.2022.07.022. Epub 2022 Aug 4. PMID: 35932819.Search in Google Scholar PubMed

16. Sreelatha, OK, Ramesh, SV. Teleophthalmology: improving patient outcomes? Clin Ophthalmol 2016;10:285–95. https://doi.org/10.2147/OPTH.S80487.Search in Google Scholar PubMed PubMed Central

17. Finès, P (2022). Sociodemographic and endogenous factors associated with access to eye care in Canada, 2016 to 2019. Health Reports: Statistics Canada. Retrieved from https://www150.statcan.gc.ca/n1/pub/82-003-x/2022012/article/00003-eng.htm on April 14, 2024Search in Google Scholar

18. Robles, R, Patel, N, Neag, E, Mittal, A, Markatia, Z, Ameli, K, et al.. A systematic review of digital ophthalmoscopes in medicine. Clin Ophthalmol 2023;17:2957–65. https://doi.org/10.2147/OPTH.S423845.Search in Google Scholar PubMed PubMed Central

19. Almazroa, A, Almatar, H, Alduhayan, R, Albalawi, M, Alghamdi, M, Alhoshan, S, et al.. The patients’ perspective for the impact of late detection of ocular diseases on quality of life: a cross-sectional study. Clin Optom 2023;15:191–204. https://doi.org/10.2147/OPTO.S422451.Search in Google Scholar PubMed PubMed Central

Received: 2024-12-15
Accepted: 2025-02-04
Published Online: 2025-02-20

© 2025 Walter de Gruyter GmbH, Berlin/Boston

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