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Influence of GSTM1, GSTT1, and GSTP1 genetic polymorphisms on disorders in transplant patients: a systematic review

  • Murilo Pita-Oliveira and Fernanda Rodrigues-Soares EMAIL logo
Published/Copyright: December 1, 2021
Drug Metabolism and Personalized Therapy
From the journal Drug Metabolism and Personalized Therapy Volume 37 Issue 2

Abstract

The glutathione-S-transferase (GST) enzymes are phase II isoenzymes responsible for protection against free radicals and xenobiotics. Since these proteins are described as polymorphic, polymorphisms in genes that encode them may alter enzymatic function and contribute to oxidative stress. In this context, such polymorphisms were already associated with several diseases and multiple therapeutic outcomes. A systematic review was performed to evaluate studies regarding the association between polymorphisms in three genes encoding enzymes of the GST family – GSTM1, GSTT1, and GSTP1 – and disorders in transplant patients. A total of 125 articles on which inclusion and exclusion criteria were applied were identified at PubMed database. Thirty-two studies met the target criteria and were included in the review. The mechanisms by which GST genotypes influence the development of disorders in transplant patients differ by disorder: they may participate in it by decreasing metabolism of drugs administered to patients undergoing transplantation, then exposing them to greater toxicity; by decreasing the repair ability against oxidative stress; or by encoding proteins that may be recognized as foreign, setting of an alloimmune reaction. Although some results are better established – such as GSTM1 null genotype’s role in the development of toxicity events in transplant patients – others require further evidences, as GST influence on the development of pulmonary decline and posttransplant diabetes mellitus (PTDM). The importance of investigating these associations lies in a personalized medicine, in which the high-risk genotype patient has its treatment individualized and its care for prophylaxis and surveillance increased, potentially reducing this population’s morbimortality.

Keywords: disorder; genetics; glutathione-S-transferase (GST); polymorphism; transplant
Corresponding author: Fernanda Rodrigues-Soares, PhD, Departamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Rua Vigário Carlos, 100, Abadia, Uberaba, Minas Gerais, CEP 38025-350, Brazil, Phone: +55 34 3700 6434, E-mail:

Acknowledgments

We thank the members of Population Genetics and Pharmacogenetics research group for interactions and discussions.

  1. Research funding: None declared.

  2. Author contributions: MP-O and FR-S designed the study and wrote the paper. MP-O performed the search, data collection and analyses. All authors approved the final manuscript and participated in the submission process.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

References

1. Strange, RC, Spiteri, MA, Ramachandran, S, Fryer, AA. Glutathione-S-transferase family of enzymes. Mutat Res Fund Mol Mech Mutagen 2001;482:21–6. https://doi.org/10.1016/s0027-5107(01)00206-8.Search in Google Scholar

2. Hayes, JD, Flanagan, JU, Jowsey, IR. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005;45:51–88. https://doi.org/10.1146/annurev.pharmtox.45.120403.095857.Search in Google Scholar

3. Klusek, J, Nasierowska-guttmejer, A, Kowalik, A. GSTM1, GSTT1, and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers. Oncotarget 2018;9:21224–30. https://doi.org/10.18632/oncotarget.25031.Search in Google Scholar

4. Bruhn, C, Brockmöller, J, Kerb, R, Roots, I, Borchert, HH. Concordance between enzyme activity and genotype of glutathione S-transferase theta (GSTT1). Biochem Pharmacol 1998;56:1189–93. https://doi.org/10.1016/s0006-2952(98)00191-9.Search in Google Scholar

5. Ali-Osman, F, Akande, O, Antoun, G, Mao, JX, Buolamwini, J. Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants: evidence for differential catalytic activity of the encoded proteins. J Biol Chem 1997;272:10004–12. https://doi.org/10.1074/jbc.272.15.10004.Search in Google Scholar PubMed

6. Watson, MA, Stewart, RK, Smith, GBJ, Massey, TE, Bell, DA. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis 1998;19:275–80. https://doi.org/10.1093/carcin/19.2.275.Search in Google Scholar PubMed

7. Klautau-guimarães, MDN, Hiragi, CDO, Ascenção, RFD, Oliveira, SF, Grisolia, CK, Hatagima, A, et al.. Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Brazilian Amerindians. Genet Mol Biol 2005;35:32–5.10.1590/S1415-47572005000100005Search in Google Scholar

8. Kong, X, Li, Z, Li, X. GSTP1, GSTM1, and GSTT1 polymorphisms as predictors of response to chemotherapy in patients with breast cancer: a meta-analysis. Cancer Chemother Pharmacol 2016;78:1163–73. https://doi.org/10.1007/s00280-016-3173-9.Search in Google Scholar PubMed

9. Chen, ZH, Xian, JF, Luo, LP. Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors. Genet Mol Res 2017;16. https://doi.org/10.4238/gmr16018877.Search in Google Scholar PubMed

10. Kassogue, Y, Diakite, B, Kassogue, O, Konate, I, Tamboura, K, Diarra, Z. Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population. Mol Biol Rep 2020;47:393–400. https://doi.org/10.1007/s11033-019-05143-5.Search in Google Scholar PubMed

11. Ginsberg, G, Smolenski, S, Hattis, D, Guyton, KZ, Johns, DO, Sonawane, B. Genetic polymorphism in glutathione transferases (GST): population distribution of GSTM1, T1, and P1 conjugating activity. J Toxicol Environ Health B Crit Rev 2009;12:389–439. https://doi.org/10.1080/10937400903158375.Search in Google Scholar PubMed

12. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG, Group, TP. Preferred reporting Items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009;6. https://doi.org/10.1136/bmj.b2535.Search in Google Scholar PubMed PubMed Central

13. Tsai, JP, Yang, SF, Wu, SW, Hung, TW, Tsai, HC, Lian, JD, et al.. Glutathione S-transferase gene polymorphisms are not major risks for susceptibility to posttransplantation diabetes mellitus in Taiwan renal transplant recipients. J Clin Lab Anal 2011;25:432–5. https://doi.org/10.1002/jcla.20498.Search in Google Scholar PubMed PubMed Central

14. Musavi, Z, Moasser, E, Zareei, N, Azarpira, N, Shamsaeefar, A. Glutathione S-transferase gene polymorphisms and the development of new-onset diabetes after liver transplant. Exp Clin Transplant 2019;17:375–80. https://doi.org/10.6002/ect.2016.0205.Search in Google Scholar PubMed

15. Marshall, SE, Bordea, C, Haldar, NA, Mullighan, CG, Wojnarowska, F, Morris, PJ, et al.. Glutathione S-transferase polymorphisms and skin cancer after renal transplantation. Kidney Int 2000;58:2186–93. https://doi.org/10.1111/j.1523-1755.2000.00392.x.Search in Google Scholar PubMed

16. Ramsay, HM, Harden, PN, Reece, S, Smith, AG, Jones, PW, Strange, RC, et al.. Polymorphisms in glutathione S-transferases are associated with altered risk of nonmelanoma skin cancer in renal transplant recipients: a preliminary analysis. J Invest Dermatol 2001;117:251–5. https://doi.org/10.1046/j.0022-202x.2001.01357.x.Search in Google Scholar PubMed

17. Fryer, AA, Ramsay, HM, Lovatt, TJ, Jones, PW, Hawley, CM, Nicol, DL, et al.. Polymorphisms in glutathione S-transferases and non-melanoma skin cancer risk in Australian renal transplant recipients. Carcinogenesis 2005;26:185–91. https://doi.org/10.1093/carcin/bgh291.Search in Google Scholar PubMed

18. Lira, MG, Provezza, L, Malerba, G, Naldi, L, Remuzzi, G, Boschiero, L, et al.. Glutathione S-transferase and CYP1A1 gene polymorphisms and non-melanoma skin cancer risk in Italian transplanted patients. Exp Dermatol 2006;15:958–65. https://doi.org/10.1111/j.1600-0625.2006.00500.x.Search in Google Scholar PubMed

19. St. Peter, SD, Imber, CJ, Jones, DC, Fuggle, SV, Watson, CJ, Friend, PJ, et al.. Genetic determinants of delayed graft function after kidney transplantation. Transplantation 2002;74:809–13. https://doi.org/10.1097/00007890-200209270-00013.Search in Google Scholar PubMed

20. Singh, R, Manchanda, PK, Kesarwani, P, Srivastava, A, Mittal, RD. Influence of genetic polymorphisms in GSTM1, GSTM3, GSTT1 and GSTP1 on allograft outcome in renal transplant recipients. Clin Transplant 2009;23:490–8. https://doi.org/10.1111/j.1399-0012.2009.00985.x.Search in Google Scholar PubMed

21. Azarpira, N, Nikeghbalian, S, Geramizadeh, B, Darai, M. Influence of glutathione S-transferase M1 and T1 polymorphisms with acute rejection in Iranian liver transplant recipients. Mol Biol Rep 2010;37:21–5. https://doi.org/10.1007/s11033-009-9487-5.Search in Google Scholar

22. Akgul, SU, Oguz, FS, Çalişkan, Y, Kekik, C, Gürkan, H, Türkmen, A, et al.. The effect of glutathion S-transferase polymorphisms and anti-GSST1 antibodies on allograft functions in recipients of renal transplant. In: Transplantation proceedings. New York: Elsevier; 2012:1679–84 pp.10.1016/j.transproceed.2012.04.004Search in Google Scholar

23. Kamei, H, Masuda, S, Nakamura, T, Fujimoto, Y, Oike, F, Ogura, Y, et al.. Impact of glutathione S-transferase T1 gene polymorphisms on acute cellular rejection in living donor liver transplantation. Transpl Immunol 2013;28:14–7. https://doi.org/10.1016/j.trim.2012.11.002.Search in Google Scholar

24. Azmandian, J, Mandegary, A, Pootari, M, Nematolahi, MH, Ebadzadeh, MR, Habibzadeh, SD, et al.. Role of donors and recipients’ glutathione S-transferase gene polymorphisms in association of oxidative stress with delayed graft function in kidney allograft recipients. Iran J Kidney Dis 2017;11:241–8.Search in Google Scholar

25. Aguilera, I, Wichmann, I, Sousa, JM, Bernardos, A, Franco, E, Garcia-Lozano, R, et al.. Antibodies against glutathione S-transferase T1 in patients with immune hepatitis after liver transplantation. Clin Exp Immunol 2001;35:712. https://doi.org/10.1016/s0041-1345(03)00059-9.Search in Google Scholar

26. Aguilera, I, Sousa, JM, Gavilán, F, Bernardos, A, Wichmann, I, Nuñez-Roldán, A. Glutathione S-transferase T1 mismatch constitutes a risk factor for de novo immune hepatitis after liver transplantation. Liver Transplant 2004;10:1166–72. https://doi.org/10.1002/lt.20209.Search in Google Scholar PubMed

27. Pagliuso, RG, Abbud-Filho, M, Alvarenga, MPS, Ferreira-Baptista, MAS, Biselli, JM, Biselli, PM, et al.. Role of glutathione S-transferase polymorphisms and chronic allograft dysfunction. Transplant Proc 2008;40:743–5. https://doi.org/10.1016/j.transproceed.2008.03.008.Search in Google Scholar PubMed

28. Srivastava, A, Poonkuzhali, B, Shaji, RV, George, B, Mathews, V, Chandy, M, et al.. Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood 2004;104:1574–7. https://doi.org/10.1182/blood-2003-11-3778.Search in Google Scholar PubMed

29. Terakura, S, Murata, M, Nishida, T, Emi, N, Akatsuka, Y, Morishima, Y, et al.. Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients. Bone Marrow Transplant 2006;37:381–6. https://doi.org/10.1038/sj.bmt.1705257.Search in Google Scholar PubMed

30. Zwaveling, J, Press, RR, Bredius, RGM, Van Derstraaten, TRJHM, Den Hartigh, J, Bartelink, IH, et al.. Glutathione S-transferase polymorphisms are not associated with population pharmacokinetic parameters of busulfan in pediatric patients. Ther Drug Monit 2008;30:504–10. https://doi.org/10.1097/ftd.0b013e3181817428.Search in Google Scholar

31. Ansari, M, Lauzon-Joset, JF, Vachon, MF, Duval, M, Théoret, Y, Champagne, MA, et al.. Influence of GST gene polymorphisms on busulfan pharmacokinetics in children. Bone Marrow Transplant 2010;45:261–7. https://doi.org/10.1038/bmt.2009.143.Search in Google Scholar PubMed

32. Elhasid, R, Krivoy, N, Rowe, JM, Sprecher, E, Adler, L, Elkin, H, et al.. Influence of glutathione S -transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer 2010;55:1172–9. https://doi.org/10.1002/pbc.22739.Search in Google Scholar PubMed

33. Krivoy, N, Zuckerman, T, Elkin, H, Froymovich, L, Rowe, JM, Efrati, E. Pharmacokinetic and pharmacogenetic analysis of oral busulfan in stem cell transplantation: prediction of poor drug metabolism to prevent drug toxicity. Curr Drug Saf 2012;7:211–7. https://doi.org/10.2174/157488612803251324.Search in Google Scholar PubMed

34. Ten Brink, MH, Wessels, JA, Hartigh, JD, Van Der Straaten, T, Von Dem Borne, PA, Guchelaar, HJ, et al.. Effect of genetic polymorphisms in genes encoding GST isoenzymes on BU pharmacokinetics in adult patients undergoing hematopoietic SCT. Bone Marrow Transplant 2012;47:190–5. https://doi.org/10.1038/bmt.2011.55.Search in Google Scholar PubMed

35. Khosravi, M, Izaddoust, M, Saadat, I, Karimi, M, Ramzi, M. Association of GSTO2 (N142D), GSTT1, and GSTM1 polymorphisms with graft-versus-host disease in allogeneic hematopoietic stem cell transplant recipients. Exp Clin Transplant 2016;14:436–40. https://doi.org/10.6002/ect.2014.0111.Search in Google Scholar PubMed

36. Terakura, S, Onizuka, M, Fukumoto, M, Kuwatsuka, Y, Kohno, A, Ozawa, Y, et al.. Analysis of glutathione S-transferase and cytochrome P450 gene polymorphism in recipients of dose-adjusted busulfan-cyclophosphamide conditioning. Int J Hematol 2020;111:84–92. https://doi.org/10.1007/s12185-019-02741-8.Search in Google Scholar PubMed

37. Goekkurt, E, Stoehlmacher, J, Stueber, C, Wolschke, C, Eiermann, T, Iacobelli, S, et al.. Pharmacogenetic analysis of liver toxicity after busulfan/cyclophosphamide- based allogeneic hematopoietic stem cell transplantation. Anticancer Res 2007;27:4377–80.Search in Google Scholar

38. Hahn, T, Zhelnova, E, Sucheston, L, Demidova, I, Savchenko, V, Battiwalla, M, et al.. A deletion polymorphism in glutathione-S-transferase mu (GSTM1) and/or theta (GSTT1) is associated with an increased risk of toxicity after autologous blood and marrow transplantation. Biol Blood Marrow Transplant 2010;16:801–8. https://doi.org/10.1016/j.bbmt.2010.01.001.Search in Google Scholar PubMed

39. Yin, J, Xiao, Y, Zheng, H, Zhang, YC. Once-daily i.v. BU-based conditioning regimen before allogeneic hematopoietic SCT: a study of influence of GST gene polymorphisms on BU pharmacokinetics and clinical outcomes in Chinese patients. Bone Marrow Transplant 2015;50:696–705. https://doi.org/10.1038/bmt.2015.14.Search in Google Scholar PubMed

40. Ansari, M, Huezo-Diaz, P, Rezgui, MA, Marktel, S, Duval, M, Bittencourt, H, et al.. Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients. Bone Marrow Transplant 2016;51:377–83. https://doi.org/10.1038/bmt.2015.321.Search in Google Scholar PubMed PubMed Central

41. Shinozuka, K, Tang, H, Jones, RB, Li, D, Nieto, Y. Impact of polymorphic variations of gemcitabine metabolism, DNA damage repair, and drug-resistance genes on the effect of high-dose chemotherapy for relapsed or refractory lymphoid malignancies. Biol Blood Marrow Transplant 2016;22:843–9. https://doi.org/10.1016/j.bbmt.2015.12.022.Search in Google Scholar PubMed PubMed Central

42. Nampoothiri, RV, Kasudhan, KS, Patil, AN, Malhotra, P, Khadwal, A, Prakash, G, et al.. Impact of frailty, melphalan pharmacokinetics, and pharmacogenetics on outcomes post autologous hematopoietic cell transplantation for multiple myeloma. Bone Marrow Transplant 2019;54:2088–95. https://doi.org/10.1038/s41409-019-0631-0.Search in Google Scholar PubMed

43. Chang, HR, Tsai, JP, Yang, SF, Lin, CK, Lian, JD. Glutathione S-transferase M1 gene polymorphism is associated with susceptibility to impaired long-term allograft outcomes in renal transplant recipients. World J Surg 2013;37:466–72. https://doi.org/10.1007/s00268-012-1815-6.Search in Google Scholar

44. Stark, J, Renbarger, J, Slaven, J, Yu, Z, Then, J, Skiles, J, et al.. Glutathione-S-transferase P1 may predispose children to a decline in pulmonary function after stem cell transplant. Pediatr Pulmonol 2017;52:916–21. https://doi.org/10.1002/ppul.23678.Search in Google Scholar

45. Bahl, D, Haddad, Z, Datoo, A, Qazi, YA. Delayed graft function in kidney transplantation. Curr Opin Organ Transplant 2019;24:82–6. https://doi.org/10.1097/mot.0000000000000604.Search in Google Scholar

46. Hu, X, Su, M, Lin, J, Zhang, L, Sun, W, Zhang, J, et al.. Corin is downregulated in renal ischemia/reperfusion injury and is associated with delayed graft function after kidney transplantation. Dis Markers 2019;2019. https://doi.org/10.1155/2019/9429323.Search in Google Scholar

47. Ha, H, Park, J, Kim, YS, Endou, H. Oxidative stress and chornic allograft nephropathy. Yonsei Med J 2004;45:1049–52. https://doi.org/10.3349/ymj.2004.45.6.1049.Search in Google Scholar

48. El-Zoghby, ZM, Stegall, MD, Lager, DJ, Kremers, WK, Amer, H, Gloor, JM, et al.. Identifying specific causes of kidney allograft loss. Am J Transplant 2009;9:527–35. https://doi.org/10.1111/j.1600-6143.2008.02519.x.Search in Google Scholar

49. Bertram, JS. The molecular biology of cancer. Mol Aspect Med 2001;21:167–223.10.1016/S0098-2997(00)00007-8Search in Google Scholar

50. DeLeve, LD, Wang, X. Role of oxidative stress and glutathione in busulfan toxicity in cultured murine hepatocytes. Pharmacology 2000;60:143–54. https://doi.org/10.1159/000028359.Search in Google Scholar PubMed

51. DeLeve, LD. Hepatic venoocclusive disease: a major complication of hematopoietic stem cell transplantation in cancer patients. Tumori 2001;87:27–9. https://doi.org/10.1177/030089160108700224.Search in Google Scholar

52. Dignan, FL, Wynn, RF, Hadzic, N, Karani, J, Quaglia, A, Pagliuca, A, et al.. BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation. Br J Haematol 2013;163:444–57. https://doi.org/10.1111/bjh.12558.Search in Google Scholar PubMed

53. Bartelink, IH, Lalmohamed, A, van Reij, EM, Dvorak, CC, Savic, RM, Zwaveling, J, et al.. Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis. Lancet Haematol 2016;3:526–36. https://doi.org/10.1016/S2352-3026(16)30114-4.Search in Google Scholar

54. Dalle, J, Giralt, SA. Biology of blood and marrow transplantation hepatic veno-occlusive disease after hematopoietic stem cell transplantation: risk factors and stratification, prophylaxis, and treatment. Biol Blood Marrow Transplant 2016;22:400–9. https://doi.org/10.1016/j.bbmt.2015.09.024.Search in Google Scholar PubMed

55. Jones, RJ, Lee, KSK, Bescheorner, WE, Vogel, VG, Grochow, LB, Braine, HG. Venooclusive disease of the liver following bone marrow transplantation. Transplantation 1987;44:778–83. https://doi.org/10.1097/00007890-198712000-00011.Search in Google Scholar PubMed

56. Mcdonald, GB, Hinds, MS, Fisher, LD, Schoch, HG, Wolford, JL, Banaji, M, et al.. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med 1993;118:255–67. https://doi.org/10.7326/0003-4819-118-4-199302150-00003.Search in Google Scholar PubMed

57. de Andrés, F, Altamirano-Tinoco, C, Ramírez-Roa, R, Montes-Mondragón, CF, Dorado, P, Peñas-Lledó, EM, et al.. Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population. Pharmacogenomics J 2021;21:140–51.10.1038/s41397-020-00190-9Search in Google Scholar PubMed

58. De Andrés, F, Terán, S, Hernández, F, Terán, E, Llerena, A. To genotype or phenotype for personalized medicine? CYP450 drug metabolizing enzyme genotype-phenotype concordance and discordance in the Ecuadorian population. OMICS A J Integr Biol 2016;20:699–710.10.1089/omi.2016.0148Search in Google Scholar PubMed

Received: 2021-07-17
Accepted: 2021-11-03
Published Online: 2021-12-01

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/dmpt-2021-0165
Keywords for this article
disorder; genetics; glutathione-S-transferase (GST); polymorphism; transplant

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Potentials of autophagy enhancing natural products in the treatment of Parkinson disease
  4. Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome
  5. Minireview
  6. Influence of GSTM1, GSTT1, and GSTP1 genetic polymorphisms on disorders in transplant patients: a systematic review
  7. Original Articles
  8. Modifying effects of TNF-α, IL-6 and VDR genes on the development risk and the course of COVID-19. Pilot study
  9. Prevalence of ABCB1 3435C>T polymorphism in the Cuban population
  10. The association of cytochrome 7A1 and ATP-binding cassette G8 genotypes with type 2 diabetes among Jordanian patients
  11. CYP2C19*2 genetic polymorphism and incidence of in-stent restenosis in patients on clopidogrel: a matched case-control study
  12. Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions
  13. Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice
  14. Cnestis ferruginea Vahl ex DC (Connaraceae) downregulates expression of immediate early genes in kainic acid-induced temporal lobe epilepsy in mice
  15. Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents
  16. Short Communication
  17. Comparison of different autoanalyzers for the determination of lymphocyte and neutrophil counts in mouse blood
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