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Prevalence of ABCB1 3435C>T polymorphism in the Cuban population

  • Idania Rodeiro Guerra ORCID logo EMAIL logo , Jose Herrea ORCID logo , Elizabeth Cuétara ORCID logo , Gabino Garrido ORCID logo , Elizabeth Reyes , Ioanna Martínez , Carlos L. Pérez ORCID logo , Gisselle Fernández , Ivones Hernández-Balmaseda , René Delgado , Julia C. Stingl and Wim Vanden Berghe EMAIL logo
Published/Copyright: December 6, 2021
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Drug Metabolism and Personalized Therapy
From the journal Drug Metabolism and Personalized Therapy Volume 37 Issue 2

Abstract

Objectives

ABCB1 gene polymorphisms can modify P-glycoprotein function with clinical consequences.

Methods

The 3435C>T polymorphism prevalence was analyzed using oligonucleotide probes and next-generation sequencing in 421 unrelated healthy individuals living in Cuba. Data were stratified by gender, ethnic background and residence. The genotype and allelic frequencies were determined.

Results

The genotype distribution met the Hardy–Weinberg equilibrium assumption. The allelic frequency was 63.5% for the 3435C variant. The genotype frequencies were 41.1% for CC, 44.9% for CT and 14.0% for TT. The allele and genotype distributions differed between individuals living in La Habana and Santiago de Cuba (p<0.05) when ethnic background was analyzed. The allelic distribution was similar among Admixed and Black subjects, and they differed from Caucasians. The CC genotype was equally distributed among Admixed and Black subjects, and they differed from Caucasians. The TT genotype frequency differed between Caucasians and Admixed. The CT genotype was distributed differently among the three groups. Similar distribution was obtained in Brazilians, whereas some similarities were observed in African, Spanish and Chinese populations, consistent with the mixed Cuban ethnic origin.

Conclusions

This is the first report on allele and genotype frequencies of the 3435C>T polymorphism in Cuba, which may support personalized medicine programs.

Keywords: 3435C>T polymorphism; ABCB1 ; Cuban population; pharmacogenetics
Corresponding authors: Idania Rodeiro Guerra, PhD, Departamento de Farmacología, Instituto de Ciencias del Mar (ICIMAR), Loma y 37, Alturas del Vedado, P.O. Box 10400, La Habana, Cuba, E-mail: ; and Wim Vanden Berghe, PhD, Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Integrated Personalized and Precision Oncology Network (IPPON), University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium, E-mail:

Funding source: Ministerio de Ciencia, Tecnología y Medio Ambiente

Funding source: Vlaamse Interuniversitaire Raad

  1. Research funding: This study was supported by the research project “Desarrollo de algoritmos de toma de decisión basados en conocimiento experto como herramientas para introducir en Cuba el manejo terapéutico personalizado del cáncer de pulmón” (PNCB, MES-CITMA, La Habana, Cuba) and the VLIR TEAM/Own Initiatives-Programme 2016 ZEIN2016PR420. Authors may also thank Dr. Adrián Llerena for the revision and suggestions made to the manuscript.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study was conducted in agreement with the recommendations of the Ethics Committee from the National Institute of Oncology and Radiobiology, Havana, Cuba.

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Received: 2020-10-14
Accepted: 2021-09-15
Published Online: 2021-12-06

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/dmpt-2020-0156
Keywords for this article
3435C>T polymorphism; ABCB1; Cuban population; pharmacogenetics

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Potentials of autophagy enhancing natural products in the treatment of Parkinson disease
  4. Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome
  5. Minireview
  6. Influence of GSTM1, GSTT1, and GSTP1 genetic polymorphisms on disorders in transplant patients: a systematic review
  7. Original Articles
  8. Modifying effects of TNF-α, IL-6 and VDR genes on the development risk and the course of COVID-19. Pilot study
  9. Prevalence of ABCB1 3435C>T polymorphism in the Cuban population
  10. The association of cytochrome 7A1 and ATP-binding cassette G8 genotypes with type 2 diabetes among Jordanian patients
  11. CYP2C19*2 genetic polymorphism and incidence of in-stent restenosis in patients on clopidogrel: a matched case-control study
  12. Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions
  13. Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice
  14. Cnestis ferruginea Vahl ex DC (Connaraceae) downregulates expression of immediate early genes in kainic acid-induced temporal lobe epilepsy in mice
  15. Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents
  16. Short Communication
  17. Comparison of different autoanalyzers for the determination of lymphocyte and neutrophil counts in mouse blood
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