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Influence of solvents and novel extraction methods on bioactive compounds and antioxidant capacity of Phyllanthus amarus

  • Van Tang Nguyen EMAIL logo , Hong Ngoc Thuy Pham , Michael C. Bowyer , Ian A. van Altena and Christopher J. Scarlett EMAIL logo
Published/Copyright: February 11, 2016
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Chemical Papers
From the journal Chemical Papers Volume 70 Issue 5

Phyllanthus amarus (P. amarus) is a herbal plant used in the treatment of various diseases such as hepatitis, diabetes, and cancer. Efficiency of its bioactive compounds extraction and therefore the biological activity of the extracts are significantly influenced by both solvent character and extraction method. This study is aimed at the determination of the influence of six various solvents (water, acetonitrile, ethanol, methanol, ethyl acetate, and dichloromethane) and nine different extraction methods (conventional, ultrasound-assisted, microwave-assisted, and six novel methods) on the extraction efficiency and antioxidant capacity of P. amarus. The results indicated that water extracted the maximal amount of phenolics from P. amarus and had the highest antioxidant capacity, while microwave-assisted extraction provided the highest yields of phenolics and saponins, and the highest antioxidant capacity with the lowest energy consumption when compared to the other extraction methods. These findings implied that water and microwave-assisted extraction are recommended as the most effective solvent and method for the extraction of bioactive compounds from P. amarus for potential application in the pharmaceutical and nutraceutical industries.

Keywords: Phyllanthus amarus; phenolics; antioxidant; solvent; extraction method

Acknowledgements

The authors sincerely acknowledge the funding support from the Ramaciotti Foundation (ES2012/0104) and the University of Newcastle, Faculty of Science and Information Technology. The authors kindly thank the Vietnamese Government through the Vietnam International Education Development-Ministry of Education and Training (Project 911) and the University of Newcastle for awarding a VIEDTUIT scholarship to Van Tang Nguyen. The authors would also like to thank the Center of Experiment and Practice at the Nha Trang University for technical support.

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Received: 2015-6-28
Revised: 2015-9-23
Accepted: 2015-10-3
Published Online: 2016-2-11
Published in Print: 2016-5-1

© 2015 Institute of Chemistry, Slovak Academy of Sciences

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  1. Original Paper
  2. Preparation and characterisation of gelatine hydrogels predisposed to use as matrices for effective immobilisation of biocatalystst‡
  3. Original Paper
  4. Photocatalytic reduction of nitro aromatic compounds to amines using a nanosized highly active CdS photocatalyst under sunlight and blue LED irradiation
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https://doi.org/10.1515/chempap-2015-0240
Keywords for this article
Phyllanthus amarus; phenolics; antioxidant; solvent; extraction method

Articles in the same Issue

  1. Original Paper
  2. Preparation and characterisation of gelatine hydrogels predisposed to use as matrices for effective immobilisation of biocatalystst‡
  3. Original Paper
  4. Photocatalytic reduction of nitro aromatic compounds to amines using a nanosized highly active CdS photocatalyst under sunlight and blue LED irradiation
  5. Original Paper
  6. Synthesis of butyrate using a heterogeneous catalyst based on polyvinylpolypyrrolidone
  7. Original Paper
  8. Behaviour of selected pesticide residues in blackcurrants (Ribes nigrum) during technological processing monitored by liquid-chromatography tandem mass spectrometry
  9. Original Paper
  10. Influence of solvents and novel extraction methods on bioactive compounds and antioxidant capacity of Phyllanthus amarus
  11. Original Paper
  12. Investigation of phytochemicals and antioxidant capacity of selected Eucalyptus species using conventional extraction
  13. Original Paper
  14. Innovative approach to treating waste waters by a membrane capacitive deionisation system
  15. Original Paper
  16. Liquid—liquid equilibria of ternary systems of 1-hexene/hexane and extraction solvents
  17. Original Paper
  18. Design of extractive distillation process with mixed entraineri‡
  19. Original Paper
  20. Kinetic study of non-reactive iron removal from iron-gall inks
  21. Original Paper
  22. Chemoenzymatic polycondensation of para-benzylamino phenol
  23. Original Paper
  24. Copper corrosion behaviour in acidic sulphate media in the presence of 5-methyl-lH-benzotriazole and 5-chloro-lH-benzotriazole
  25. Original Paper
  26. Synthesis of new 5-bromo derivatives of indole and spiroindole phytoalexins
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  28. Design, synthesis and anti-mycobacterial evaluation of some new iV-phenylpyrazine-2-carboxamides
  29. Short Communication
  30. Convenient amidation of carboxyl group of carboxyphenylboronic acids
  31. Short Communication
  32. A novel intramolecular reversible reaction between the hydroxyl group and isobutenylene chain in a cyclophane-type macrocycle
  33. Erratum
  34. Erratum to “Adriana Bakalova, Boryana Nikolova-Mladenova, Rossen Buyukliev, Emiliya Cherneva, Georgi Momekov, Darvin Ivanov: Synthesis, DFT calculations and characterisation of new mixed Pt(II) complexes with 3-thiolanespiro-5′-hydantoin and 4-thio-1H-tetrahydropyranspiro-5′-hydantoin”, Chemical Papers 70 (1) 93–100 (2016)*
  35. Erratum
  36. Erratum to “Martyna Rzelewska, Monika Baczyńska, Magdalena Regel-Rosocka, Maciej Wiśniewski: Trihexyl(tetradecyl)phosphonium bromide as extractant for Rh(III), Ru(III) and Pt(IV) from chloride solutions”, Chemical Papers 70 (4) 454–460 (2016)*
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