Startseite Evaluation of sex-specific 0-h high-sensitivity cardiac troponin T thresholds for the risk stratification of non-ST-segment elevation myocardial infarction
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Evaluation of sex-specific 0-h high-sensitivity cardiac troponin T thresholds for the risk stratification of non-ST-segment elevation myocardial infarction

  • Ailun Zhang , Guorong Gu , Jing Zhu , Wenqi Shao , Jing Yang , Baishen Pan , Beili Wang ORCID logo EMAIL logo , Chenling Yao EMAIL logo und Wei Guo EMAIL logo
Veröffentlicht/Copyright: 17. April 2025
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Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine (CCLM) Band 63 Heft 7

Abstract

Objectives

We aimed to evaluate sex-specific 0-h high-sensitivity cardiac troponin T (hs-cTnT) thresholds for risk stratification in patients with suspected non-ST-segment elevation myocardial infarction (NSTEMI).

Methods

This retrospective study investigated a derivation cohort of 6,691 (44.4 % female and aged 65 (57–72) years) and a validation cohort of 6,589 (48.4 % female and aged 63 (50–71) years) patients with suspected NSTEMI who visited the emergency department. Uniform and sex-specific thresholds were derived and validated, and their performances were compared.

Results

In the derivation cohort, 11.3 % of males and 5.4 % of females were diagnosed with adjudicated NSTEMI. As male-specific thresholds, 0-h hs-cTnT <10 ng/L ruled out 30.1 % of patients with an NPV of 99.6 % [95 % CI (99.0–99.9 %)], and 0-h hs-cTnT ≥65 ng/L ruled in 12.3 % of patients with a PPV of 70.5 % [95 % CI (66.0–74.6 %)]. As female-specific thresholds, 0-h hs-cTnT <9 ng/L ruled out 39.2 % of patients with an NPV of 99.9 % [95 % CI (99.4–100.0 %)], and 0-h hs-cTnT ≥45 ng/L ruled in 6.7 % of patients with a PPV of 71.7 % [95 % CI (64.8–77.8 %)]. The validation cohort showed similar results. Sex-specific and uniform thresholds did not significantly affect rule-in performance, whereas sex-specific thresholds increased female sensitivity by 1 % (99.7 vs. 98.7 %). Patient follow-up did not change when sex-specific thresholds were applied.

Conclusions

Sex-specific 0-h hs-cTnT thresholds could slightly improve the safety in ruling out NSTEMI in females, but their role in terms of efficiency, rule-in performance and prognosis was similar to that of uniform thresholds.

Keywords: high-sensitivity cardiac troponin T (hs-cTnT); sex-specific 0-h thresholds; non-ST-segment elevation myocardial infarction (NSTEMI); emergency department (ED)
Corresponding authors: Beili Wang, Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China, E-mail: ; Chenling Yao, Department of Emergency Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China, E-mail: ; and Wei Guo, Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China; Department of Laboratory Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China; Department of Laboratory Medicine, Wusong Branch, Zhongshan Hospital, Fudan University, Shanghai, China; and Department of Laboratory Medicine, Geriatric Medical Center, Shanghai, China, E-mail:
Ailun Zhang, Guorong Gu, Jing Zhu and Wenqi Shao contributed equally to this work and share first authorship.

Funding source: the Shanghai Baoshan Medical Key Specialty

Award Identifier / Grant number: BSZK-2023-A18

Funding source: the key medical and health projects of Xiamen

Award Identifier / Grant number: YDZX20193502000002

Funding source: Specialized Fund for the clinical researches of Zhongshan Hospital affiliated Fudan University

Award Identifier / Grant number: 2018ZSLC05, 2020ZSLC46, 2020ZSLC54

Funding source: the Projects from Excellent backbone of Zhongshan Hospital, Fudan University

Award Identifier / Grant number: 2021ZSGG08

Funding source: the National Natural Science Foundation of China

Award Identifier / Grant number: 81902139, 81972000, 82172348

Funding source: the constructing project of clinical key disciplines in Shanghai

Award Identifier / Grant number: shslczdzk03302

Funding source: the Science and Technology Commission of Shanghai Municipality

Award Identifier / Grant number: 21Y11902200， 21MC1930400

Acknowledgments

The authors thank the patients who participated in this research, the emergency department clinicians and the laboratory technicians of all participating sites for their valuable effort. The authors also deeply appreciate the support and coordination of Shanghai Huidr Information Technology Co., Ltd. in patient follow-up.

  1. Research ethics: This retrospective study was approved by the Ethics Committee of Zhongshan Hospital Affiliated with Fudan University (B2023-044R) for human studies.

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: All authors state no conflict of interest.

  6. Research funding: This work was supported by the National Natural Science Foundation of China (81902139, 81972000, 82172348), the constructing project of clinical key disciplines in Shanghai (shslczdzk03302), the Science and Technology Commission of Shanghai Municipality (21Y11902200; 21MC1930400), Specialized Fund for the clinical researches of Zhongshan Hospital affiliated Fudan University (2018ZSLC05, 2020ZSLC46, 2020ZSLC54), the key medical and health projects of Xiamen (YDZX20193502000002), the Projects from Excellent backbone of Zhongshan Hospital, Fudan University (2021ZSGG08), and Shanghai Baoshan Medical Key Specialty(BSZK-2023-A18).

  7. Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

1. Collet, JP, Thiele, H, Barbato, E, Barthelemy, O, Bauersachs, J, Bhatt, DL, et al.. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 2021;42:1289–367. https://doi.org/10.1093/eurheartj/ehaa575.Suche in Google Scholar PubMed

2. Neumann, JT, Sorensen, NA, Rubsamen, N, Ojeda, F, Schafer, S, Keller, T, et al.. Right bundle branch block in patients with suspected myocardial infarction. Eur Heart J Acute Cardiovasc Care 2019;8:161–6. https://doi.org/10.1177/2048872618809700.Suche in Google Scholar PubMed

3. Sandoval, Y, Nowak, R, DeFilippi, CR, Christenson, RH, Peacock, WF, McCord, J, et al.. Myocardial infarction risk stratification with a single measurement of high-sensitivity troponin I. J Am Coll Cardiol 2019;74:271–82. https://doi.org/10.1016/j.jacc.2019.05.058.Suche in Google Scholar PubMed

4. Sörensen, NA, Goßling, A, Neumann, JT, Hartikainen, TS, Haller, PM, Scharlemann, L, et al.. Diagnostic validation of a high-sensitivity cardiac troponin I assay. Clin Chem 2021;67:1230–9. https://doi.org/10.1093/clinchem/hvab070.Suche in Google Scholar PubMed

5. Lopez-Ayala, P, Boeddinghaus, J, Koechlin, L, Nestelberger, T, Mueller, C. Early rule-out strategies in the emergency department utilizing high-sensitivity cardiac troponin assays. Clin Chem 2021;67:114–23. https://doi.org/10.1093/clinchem/hvaa226.Suche in Google Scholar PubMed

6. Fabre-Estremera, B, Smith, SW, Sandoval, Y, Schulz, K, Okeson, B, Cullen, L, et al.. Rapid rule-out of myocardial infarction using a single high-sensitivity cardiac troponin I measurement strategy at presentation to the emergency department: the SAFETY study. Clin Chem 2023;69:627–36. https://doi.org/10.1093/clinchem/hvad033.Suche in Google Scholar PubMed

7. Gulati, M, Levy, PD, Mukherjee, D, Amsterdam, E, Bhatt, DL, Birtcher, KK, et al.. AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology/American heart association joint committee on clinical practice guidelines. J Am Coll Cardiol 2021;78:e187–285, https://doi.org/10.1016/j.jacc.2021.07.053.Suche in Google Scholar PubMed

8. Chaulin, A. Modern view on the role of sex-specific levels of high-sensitive cardiospecific troponins T and I in the diagnosis of myocardial infarction. Cardiol Res 2023;14:22–31. https://doi.org/10.14740/cr1450.Suche in Google Scholar PubMed PubMed Central

9. Gartner, C, Langhammer, R, Schmidt, M, Federbusch, M, Wirkner, K, Loffler, M, et al.. Revisited upper reference limits for highly sensitive cardiac troponin T in relation to age, sex, and renal function. J Clin Med 2021;10. https://doi.org/10.3390/jcm10235508.Suche in Google Scholar PubMed PubMed Central

10. Bhatia, PM, Daniels, LB. Highly sensitive cardiac troponins: the evidence behind sex-specific cutoffs. J Am Heart Assoc 2020;9:e15272. https://doi.org/10.1161/jaha.119.015272.Suche in Google Scholar PubMed PubMed Central

11. Sandoval, Y, Apple, FS, Mahler, SA, Body, R, Collinson, PO, Jaffe, AS. High-sensitivity cardiac troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guidelines for the evaluation and diagnosis of acute chest pain. Circulation 2022;146:569–81. https://doi.org/10.1161/circulationaha.122.059678.Suche in Google Scholar PubMed

12. Montgomery, CM, Ashburn, NP, Snavely, AC, Allen, B, Christenson, R, Madsen, T, et al.. Sex-specific high-sensitivitytroponin T cut-points have similar safety but lower efficacy than overall cut-points in a multisiteU.S. cohort. Acad Emerg Med 2024;32:45–53. https://doi.org/10.1111/acem.15014.Suche in Google Scholar PubMed PubMed Central

13. Lehmacher, J, Sörensen, NA, Twerenbold, R, Goßling, A, Haller, PM, Hartikainen, TS, et al.. Diagnostic and prognostic value of the sex-specific 99th percentile of four high-sensitivity cardiac troponin assays in patients with suspected myocardial infarction. Eur Heart J: Acute Cardiovascular Care 2024;13:3–12. https://doi.org/10.1093/ehjacc/zuad131.Suche in Google Scholar PubMed

14. Lobo, R, De Michieli, L, Jaffe, AS. Sex-specific 99th percentile URLs for cardiac troponin assays-their time has come. Clin Chem 2021;67:197–200. https://doi.org/10.1093/clinchem/hvaa204.Suche in Google Scholar PubMed

15. Gutierrez, OM, Sang, Y, Grams, ME, Ballew, SH, Surapaneni, A, Matsushita, K, et al.. Association of estimated GFR calculated using race-free equations with kidney failure and mortality by black vs non-black race. JAMA 2022;327:2306–16. https://doi.org/10.1001/jama.2022.8801.Suche in Google Scholar PubMed PubMed Central

16. Cohen, M, Visveswaran, G. Defining and managing patients with non-ST-elevation myocardial infarction: sorting through type 1 vs other types. Clin Cardiol 2020;43:242–50. https://doi.org/10.1002/clc.23308.Suche in Google Scholar PubMed PubMed Central

17. Thygesen, K, Alpert, JS, Jaffe, AS, Chaitman, BR, Bax, JJ, Morrow, DA, et al.. Fourth universal definition of myocardial infarction (2018). J Am Coll Cardiol 2018;72:2231–64. https://doi.org/10.1016/j.jacc.2018.08.1038.Suche in Google Scholar PubMed

18. Bosco, E, Hsueh, L, McConeghy, KW, Gravenstein, S, Saade, E. Major adverse cardiovascular event definitions used in observational analysis of administrative databases: a systematic review. BMC Med Res Methodol 2021;21:241. https://doi.org/10.1186/s12874-021-01440-5.Suche in Google Scholar PubMed PubMed Central

19. McRae, A, Graham, M, Abedin, T, Ji, Y, Yang, H, Wang, D, et al.. Sex-specific, high-sensitivity cardiac troponin T cut-off concentrations for ruling out acute myocardial infarction with a single measurement. CJEM 2019;21:26–33. https://doi.org/10.1017/cem.2018.435.Suche in Google Scholar PubMed

20. Chen, C, Yu, Y, Chen, D, Cai, C, Zhou, Y, Liao, F, et al.. Derivation of a HEAR pathway for emergency department chest pain patients to safely avoid a second troponin test. Diagn (Basel) 2023;13. https://doi.org/10.3390/diagnostics13203217.Suche in Google Scholar PubMed PubMed Central

21. Guangquan, L, Hualan, H, Xin, N, Yong, H, Haolan, S, Tongxing, L, et al.. Time from symptom onset influences high-sensitivity troponin T diagnostic accuracy for the diagnosis of acute myocardial infarction. Clin Chem Lab Med 2016;54:133–42. https://doi.org/10.1515/cclm-2014-0776.Suche in Google Scholar PubMed

22. Sandoval, Y, Lewis, BR, Mehta, RA, Ola, O, Knott, JD, De Michieli, L, et al.. Rapid exclusion of acute myocardial injury and infarction with a single high-sensitivity cardiac troponin T in the emergency department: a multicenter United States evaluation. Circulation 2022;145:1708–19. https://doi.org/10.1161/circulationaha.122.059235.Suche in Google Scholar PubMed PubMed Central

23. de Barros, ESPGM, Ferreira, AA, Malafaia, F, Tavares Reis, AFM, Sznejder, H, Lopes, JACDA, et al.. Potential performance of a 0 h/1 h algorithm and a single cut-off measure of high-sensitivity troponin T in a diverse population: main results of the IN-HOPE study. Eur Heart J: Acute Cardiovasc Care 2023;12:755–64. https://doi.org/10.1093/ehjacc/zuad082.Suche in Google Scholar PubMed

24. Sandeman, D, Syed, MBJ, Kimenai, DM, Lee, KK, Anand, A, Joshi, SS, et al.. Implementation of an early rule-out pathway for myocardial infarction using a high-sensitivity cardiac troponin T assay. Open Heart 2021;8:e1769. https://doi.org/10.1136/openhrt-2021-001769.Suche in Google Scholar PubMed PubMed Central

25. McRae, AD, Innes, G, Graham, M, Lang, E, Andruchow, JE, Ji, Y, et al.. Undetectable concentrations of a food and drug administration–approved high-sensitivity cardiac troponin T assay to rule out acute myocardial infarction at emergency department arrival. Acad Emerg Med 2017;24:1267–77. https://doi.org/10.1111/acem.13229.Suche in Google Scholar PubMed PubMed Central

26. Steiro, OT, Langorgen, J, Tjora, HL, Bjorneklett, RO, Skadberg, O, Bonarjee, V, et al.. Prognostic significance of chronic myocardial injury diagnosed by three different cardiac troponin assays in patients admitted with suspected acute coronary syndrome. Clin Chem Lab Med 2023;62:729–39. https://doi.org/10.1515/cclm-2023-0336.Suche in Google Scholar PubMed

27. Chapman, AR, Lee, KK, McAllister, DA, Cullen, L, Greenslade, JH, Parsonage, W, et al.. Association of high-sensitivity cardiac troponin I concentration with cardiac outcomes in patients with suspected acute coronary syndrome. JAMA 2017;318:1913. https://doi.org/10.1001/jama.2017.17488.Suche in Google Scholar PubMed PubMed Central

28. Tjora, HL, Steiro, OT, Langorgen, J, Bjorneklett, R, Nygard, OK, Skadberg, O, et al.. Cardiac troponin assays with improved analytical quality: a trade-off between enhanced diagnostic performance and reduced long-term prognostic value. J Am Heart Assoc 2020;9:e17465. https://doi.org/10.1161/jaha.120.017465.Suche in Google Scholar PubMed PubMed Central

29. Carlton, EW, Ingram, J, Taylor, H, Glynn, J, Kandiyali, R, Campbell, S, et al.. Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial. Heart 2020;106:1586–94. https://doi.org/10.1136/heartjnl-2020-316692.Suche in Google Scholar PubMed PubMed Central

30. Bularga, A, Lee, KK, Stewart, S, Ferry, AV, Chapman, AR, Marshall, L, et al.. High-sensitivity troponin and the application of risk stratification thresholds in patients with suspected acute coronary syndrome. Circulation 2019;140:1557–68. https://doi.org/10.1161/circulationaha.119.042866.Suche in Google Scholar

31. Li, Z, Wereski, R, Anand, A, Lowry, M, Doudesis, D, McDermott, M, et al.. Uniform or sex-specific cardiac troponin thresholds to rule out myocardial infarction at presentation. J Am Coll Cardiol 2024;83:1855–66. https://doi.org/10.1016/j.jacc.2024.03.365.Suche in Google Scholar PubMed

32. Montgomery, CM, Ashburn, NP, Snavely, AC, Allen, B, Christenson, R, Madsen, T, et al.. Sex-specific high-sensitivity troponin T cut-points have similar safety but lower efficacy than overall cut-points in a multisite U.S. cohort. Acad Emerg Med 2024;32:45–53. https://doi.org/10.1111/acem.15014.Suche in Google Scholar PubMed PubMed Central

Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/cclm-2024-1118).

Received: 2024-09-23
Accepted: 2025-03-04
Published Online: 2025-04-17
Published in Print: 2025-06-26

© 2025 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/cclm-2024-1118
Schlagwörter für diesen Artikel
high-sensitivity cardiac troponin T (hs-cTnT); sex-specific 0-h thresholds; non-ST-segment elevation myocardial infarction (NSTEMI); emergency department (ED)

Artikel in diesem Heft

  1. Frontmatter
  2. Editorials
  3. The journey to pre-analytical quality
  4. Manual tilt tube method for prothrombin time: a commentary on contemporary relevance
  5. Reviews
  6. From errors to excellence: the pre-analytical journey to improved quality in diagnostics. A scoping review
  7. Advancements and challenges in high-sensitivity cardiac troponin assays: diagnostic, pathophysiological, and clinical perspectives
  8. Opinion Paper
  9. Is it feasible for European laboratories to use SI units in reporting results?
  10. Perspectives
  11. What does cancer screening have to do with tomato growing?
  12. Computer simulation approaches to evaluate the interaction between analytical performance characteristics and clinical (mis)classification: a complementary tool for setting indirect outcome-based analytical performance specifications
  13. Genetics and Molecular Diagnostics
  14. Artificial base mismatches-mediated PCR (ABM-PCR) for detecting clinically relevant single-base mutations
  15. Candidate Reference Measurement Procedures and Materials
  16. Antiphospholipid IgG Certified Reference Material ERM®-DA477/IFCC: a tool for aPL harmonization?
  17. General Clinical Chemistry and Laboratory Medicine
  18. External quality assessment of the manual tilt tube technique for prothrombin time testing: a report from the IFCC-SSC/ISTH Working Group on the Standardization of PT/INR
  19. Simple steps to achieve harmonisation and standardisation of dried blood spot phenylalanine measurements and facilitate consistent management of patients with phenylketonuria
  20. Inclusion of pyridoxine dependent epilepsy in expanded newborn screening programs by tandem mass spectrometry: set up of first and second tier tests
  21. Analytical performance evaluation and optimization of serum 25(OH)D LC-MS/MS measurement
  22. Towards routine high-throughput analysis of fecal bile acids: validation of an enzymatic cycling method for the quantification of total bile acids in human stool samples on fully automated clinical chemistry analyzers
  23. Analytical and clinical evaluations of Snibe Maglumi® S100B assay
  24. Prevalence and detection of citrate contamination in clinical laboratory
  25. Reference Values and Biological Variations
  26. Temporal dynamics in laboratory medicine: cosinor analysis and real-world data (RWD) approaches to population chronobiology
  27. Establishing sex- and age-related reference intervals of serum glial fibrillary acid protein measured by the fully automated lumipulse system
  28. Hematology and Coagulation
  29. Performance of the automated digital cell image analyzer UIMD PBIA in white blood cell classification: a comparative study with sysmex DI-60
  30. Cancer Diagnostics
  31. Flow-cytometric MRD detection in pediatric T-ALL: a multicenter AIEOP-BFM consensus-based guided standardized approach
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  40. Reply to “Is this quantitative test fit-for-purpose?”
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  42. The first case of Teclistamab interference with serum electrophoresis and immunofixation
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  46. Congress Abstracts
  47. 10th Annual Meeting of the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC)
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