Startseite Medizin Comparison of a two-step Tempus600 hub solution single-tube vs. container-based, one-step pneumatic transport system
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Comparison of a two-step Tempus600 hub solution single-tube vs. container-based, one-step pneumatic transport system

  • Marc Luginbühl ORCID logo , Kathrin Frey ORCID logo , Joanna Gawinecka ORCID logo , Arnold von Eckardstein ORCID logo und Lanja Saleh ORCID logo EMAIL logo
Veröffentlicht/Copyright: 15. Mai 2024
Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine (CCLM) Band 62 Heft 11

Abstract

Objectives

Efficient and timely transportation of clinical samples is pivotal to ensure accurate diagnoses and effective patient care. During the transportation process, preservation of sample integrity is crucial to avoid pre-analytical aberrations on laboratory results. Here, we present a comparative analysis between a two-step Tempus600 hub solution single-tube and a one-step, container-based pneumatic transport system (PTS) from Airco, for the in-house transportation of blood samples.

Methods

Ten blood samples from healthy volunteers were split in 10 mL collection tubes filled at full or half capacity for transportation with the two PTS (about 250 m). To compare the impact of transportation, markers of hemolysis such as lactate dehydrogenase (LDH), potassium (K+), and the hemolysis index (HI), were determined. Additionally, differences in HI in routine samples and repeated transportation was investigated. To assess and compare the mechanistic impact profiles, we recorded the acceleration profiles of the two PTS using a shock data logger.

Results

Transportation using the Tempus600 hub solution resulted in 49 and 46 % higher HI with samples filled to total or half capacity, respectively. Routine samples transported with the Tempus600 hub solution showed a higher median HI by 23 and 33 %. Additionally, shock logger analysis showed an elevated amount of shocks (6.5 fold) and shock intensities (1.8 fold).

Conclusions

The Tempus600 hub solution caused an increased number of unreportable LDH or K+ results based on the hemolysis index. However, it was only statistically significant for LDH (p<0.01 and p<0.08) – while the comparisons for K+ were not statistically significant (p<0.28 and p<0.56).

Keywords: Tempus600; pneumatic transportation system; laboratory transportation; clinical chemistry
Corresponding author: Lanja Saleh, Institute for Laboratory Medicine, Triemli Hospital, Birmensdorfer Str. 497, 8063 Zurich, Switzerland, E-mail:
Marc Luginbühl and Kathrin Frey contributed equally to this work.

Acknowledgments

The authors would like to thank the team of the Institute of Clinical Chemistry at the University Hospital of Zurich for their support. Additionally, special thanks are extended to Christoph Stulz for his contributions to photography.

  1. Research ethics: This investigation was conducted as a quality assurance project of the Institute of Clinical Chemistry at the University Hospital of Zurich, to qualify the novel PTS system according to ISO 17025. The project was not subject to approval according to the Human Research Act (HRA). The use of the collected data for publication received a waiver from the hospital’s data governance board (DUP-1238).

  2. Informed consent: Written consent was obtained before the individual blood collection.

  3. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: The authors declare no potential conflicts of interest concerning research, authorship, and/ or publication of this article.

  5. Research funding: None declared.

  6. Data availability: The raw data can be obtained on request from the corresponding author.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/cclm-2024-0057).

Received: 2024-01-15
Accepted: 2024-04-04
Published Online: 2024-05-15
Published in Print: 2024-10-28

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/cclm-2024-0057
Schlagwörter für diesen Artikel
Tempus600; pneumatic transportation system; laboratory transportation; clinical chemistry

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Circulating tumor DNA measurement: a new pillar of medical oncology?
  4. Reviews
  5. Circulating tumor DNA: current implementation issues and future challenges for clinical utility
  6. Circulating tumor DNA methylation: a promising clinical tool for cancer diagnosis and management
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  10. Computational pathology: an evolving concept
  11. Perspectives
  12. Dynamic mirroring: unveiling the role of digital twins, artificial intelligence and synthetic data for personalized medicine in laboratory medicine
  13. General Clinical Chemistry and Laboratory Medicine
  14. Macroprolactin in mothers and their babies: what is its origin?
  15. The influence of undetected hemolysis on POCT potassium results in the emergency department
  16. Quality control in the Netherlands; todays practices and starting points for guidance and future research
  17. QC Constellation: a cutting-edge solution for risk and patient-based quality control in clinical laboratories
  18. OILVEQ: an Italian external quality control scheme for cannabinoids analysis in galenic preparations of cannabis oil
  19. Using Bland-Altman plot-based harmonization algorithm to optimize the harmonization for immunoassays
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