Low concentrations of adropin are associated with endothelial dysfunction as assessed by flow-mediated dilatation in patients with metabolic syndrome
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Coskun U. Oruc
und
Beyhan Omer
Abstract
Background:
In individuals with atherosclerotic risk factors, endothelial dysfunction (ED) appears as an early phase in the development of clinical symptoms. Recent studies indicate that adropin, a newly identified peptide, participates in cardiovascular health through the regulation of several metabolic events including angiogenesis and blood flow. In this study, we aimed to determine the relation of adropin with biochemical and radiologic parameters which reflect ED such as endothelial nitric oxide synthase (eNOS), endothelin 1 (ET-1), nitric oxide (NO) and flow-mediated dilatation (FMD) along with the routine biochemical measurements in patients recently diagnosed with metabolic syndrome (MetS).
Methods:
Fasting blood samples from 110 patients with MetS diagnosed according to the NCEP ATP III-2005 criteria were collected to measure the concentrations of adropin and other parameters including the lipid profile, insulin and glucose. Serum NOx concentrations were determined by measuring NO2 plus NO3. FMD test was performed by ultrasonography, and patients were stratified as FMD (+) or (–). Data were compared between these two subgroups and also with matching healthy controls (n=50). Biochemical data were evaluated using Student’s t or Mann-Whitney U tests.
Results:
Fifty-nine subjects had ED (+) and the remaining 101 subjects were ED (–). In the first group, adropin levels were significantly lower than the latter (2.13±1.05 vs. 3.41±1.63 ng/mL, respectively; p<0.001) and independently associated with FMD positivity as assessed by the logistic regression analysis.
Conclusions:
Low adropin level in circulation is related to ED and has a close association with FMD. Any alterations in its level may be of help in order to assess the development of ED before the occurrence of clinical symptoms in patients with metabolic syndrome.
Acknowledgments
This study was supported by the Research Fund of Istanbul University, project no. t-44085.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial
- Describing children’s changes using clinical chemistry analytes
- Review
- Assessment of vitamin D status – a changing landscape
- Opinion Papers
- Order of blood draw: Opinion Paper by the European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE)
- The principles of Health Technology Assessment in laboratory medicine
- Genetics and Molecular Diagnostics
- Functional polymorphism of lncRNA MALAT1 contributes to pulmonary arterial hypertension susceptibility in Chinese people
- General Clinical Chemistry and Laboratory Medicine
- Influence of pneumatic tube system transport on routinely assessed and spectrophotometric cerebrospinal fluid parameters
- Estimation of hematocrit in filter paper dried bloodspots by potassium measurement: advantage of use of perimeter ring samples over circular center sub-punch samples
- Evaluation of the first fully automated immunoassay method for the measurement of stimulating TSH receptor autoantibodies in Graves’ disease
- Comparison of four immunoassays to measure serum ferritin concentrations and iron deficiency prevalence among non-pregnant Cambodian women and Congolese children
- Activity and expression of dipeptidyl peptidase IV on peripheral blood mononuclear cells in patients with early steroid and disease modifying antirheumatic drugs naïve rheumatoid arthritis
- Hematology and Coagulation
- Neutrophil CD64 Index as a superior biomarker for early diagnosis of infection in febrile patients in the hematology department
- Dilute Russell’s viper venom time reagents in lupus anticoagulant testing: a well-considered choice
- Reference Values and Biological Variations
- Pediatric reference intervals for alkaline phosphatase
- Cancer Diagnostics
- Transcript expression and genetic variability analysis of caspases in breast carcinomas suggests CASP9 as the most interesting target
- CDH1 (E-cadherin) expression independently affects clinical outcome in acute myeloid leukemia with normal cytogenetics
- Cardiovascular Diseases
- Association of monocyte to HDL cholesterol level with contrast induced nephropathy in STEMI patients treated with primary PCI
- Low concentrations of adropin are associated with endothelial dysfunction as assessed by flow-mediated dilatation in patients with metabolic syndrome
- Preoperative serum potassium predicts the clinical outcome after non-cardiac surgery
- Diabetes
- A simple colorimetric assay for measuring fructosamine 3 kinase activity
- Acknowledgment
- Acknowledgment
- Letters to the Editor
- Normalisation issues in glucose measurements using phlebotomy tubes with liquid additives
- Utility of dilution tests in investigating interference in the free thyroxine assay
- Plasminogen activator inhibitor-1 as a marker of cardiovascular response in professional mountain ultra-marathon runners
- Pitfalls of LSD screening assays: comparison of KIMS and CEDIA immunoassays with LC-MS
- A two site comparison of two point-of-care activated clotting time systems
- Detection of the common South-East Asian β0-thalassemia mutations in samples with borderline HbA2 levels
- Biclonal plasma cell myeloma with the simultaneous appearance of both secretory lambda and nonsecretory kappa monoclonal light chains
Artikel in diesem Heft
- Frontmatter
- Editorial
- Describing children’s changes using clinical chemistry analytes
- Review
- Assessment of vitamin D status – a changing landscape
- Opinion Papers
- Order of blood draw: Opinion Paper by the European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE)
- The principles of Health Technology Assessment in laboratory medicine
- Genetics and Molecular Diagnostics
- Functional polymorphism of lncRNA MALAT1 contributes to pulmonary arterial hypertension susceptibility in Chinese people
- General Clinical Chemistry and Laboratory Medicine
- Influence of pneumatic tube system transport on routinely assessed and spectrophotometric cerebrospinal fluid parameters
- Estimation of hematocrit in filter paper dried bloodspots by potassium measurement: advantage of use of perimeter ring samples over circular center sub-punch samples
- Evaluation of the first fully automated immunoassay method for the measurement of stimulating TSH receptor autoantibodies in Graves’ disease
- Comparison of four immunoassays to measure serum ferritin concentrations and iron deficiency prevalence among non-pregnant Cambodian women and Congolese children
- Activity and expression of dipeptidyl peptidase IV on peripheral blood mononuclear cells in patients with early steroid and disease modifying antirheumatic drugs naïve rheumatoid arthritis
- Hematology and Coagulation
- Neutrophil CD64 Index as a superior biomarker for early diagnosis of infection in febrile patients in the hematology department
- Dilute Russell’s viper venom time reagents in lupus anticoagulant testing: a well-considered choice
- Reference Values and Biological Variations
- Pediatric reference intervals for alkaline phosphatase
- Cancer Diagnostics
- Transcript expression and genetic variability analysis of caspases in breast carcinomas suggests CASP9 as the most interesting target
- CDH1 (E-cadherin) expression independently affects clinical outcome in acute myeloid leukemia with normal cytogenetics
- Cardiovascular Diseases
- Association of monocyte to HDL cholesterol level with contrast induced nephropathy in STEMI patients treated with primary PCI
- Low concentrations of adropin are associated with endothelial dysfunction as assessed by flow-mediated dilatation in patients with metabolic syndrome
- Preoperative serum potassium predicts the clinical outcome after non-cardiac surgery
- Diabetes
- A simple colorimetric assay for measuring fructosamine 3 kinase activity
- Acknowledgment
- Acknowledgment
- Letters to the Editor
- Normalisation issues in glucose measurements using phlebotomy tubes with liquid additives
- Utility of dilution tests in investigating interference in the free thyroxine assay
- Plasminogen activator inhibitor-1 as a marker of cardiovascular response in professional mountain ultra-marathon runners
- Pitfalls of LSD screening assays: comparison of KIMS and CEDIA immunoassays with LC-MS
- A two site comparison of two point-of-care activated clotting time systems
- Detection of the common South-East Asian β0-thalassemia mutations in samples with borderline HbA2 levels
- Biclonal plasma cell myeloma with the simultaneous appearance of both secretory lambda and nonsecretory kappa monoclonal light chains
