The role of timely measurement of galectin-3, NT-proBNP, cystatin C and hsTnT in predicting prognosis and heart function after heart transplantation
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Janka Franeková
Abstract
Background: Changes of biomarkers measured soon after heart transplantation (HTx) can reflect different processes: cardiomyocyte necrosis (troponins, high-sensitivity cardiac TnT and TnI), heart function (natriuretic peptides, BNP and NT-proBNP), fibrosis (galectin-3 and ST2), and global cardiorenal risk (cystatin C). We assessed the prognostic role of hsTnT, NT-proBNP, galectin-3 and cystatin C during the early post-transplant period.
Methods: A total of 121 consecutive post-HTx patients were assessed. The main outcomes were survival, left ventricular ejection fraction (LVEF) and rejection periods. Survival was assessed after intermediate (12 months) and long periods (total follow-up during study, median of survival 763 days, IR 527–1038 days). LVEF was assessed 12 months after HTx. Rejection was evaluated during follow-up. We report biomarker concentrations measured 10 days and 12 months after HTx.
Results: Ten days after HTx, cystatin C and hsTnT predicted death both under univariable and multivariable analysis. These two biomarkers along with galectin-3 were increased in patients with decreased LVEF measured 1 year after HTx. NT-proBNP did not show early prognostic power. None of the measured biomarkers predicted rejection, but hsTnT and NT-proBNP were increased significantly 12 months after HTx in patients with at least one rejection.
Conclusions: Cystatin C and hsTnT measured 10 days after HTx can provide prognostic information on survival and galectin-3 measured at the same time may display a relationship to heart function assessed 1 year after HTx. Further study should be carried out in a large cohort of patients.
Acknowledgments
We express our thanks to Dr. V. Lánská for valuable comments on the statistical evaluation of results.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: Antonín Jabor received lecturer’s honoraria Abbott Laboratories Ltd., Czech Republic and Roche Ltd., Czech Republic. None of the other authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts of interest to disclose. The study was partially supported by the project for conceptual development of research organizations 00023001 (Ministry of Health, Czech Republic) and the International Grant Agency of the Ministry of Health of the Czech Republic No NT/11269-5.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Editorial
- Total error vs. measurement uncertainty: the match continues
- Review
- Application of fatty acid and lipid measurements in neuropsychiatry
- Mini Review
- The Janus faces of acquired angioedema: C1-inhibitor deficiency, lymphoproliferation and autoimmunity
- Opinion Papers
- How to report results of prothrombin and activated partial thromboplastin times
- Useful measures and models for analytical quality management in medical laboratories
- Total error vs. measurement uncertainty: revolution or evolution?
- Genetics and Molecular Diagnostics
- Rapid detection of Mmalton α1-antitrypsin deficiency allele by real-time PCR and melting curves in whole blood, serum and dried blood spot samples
- General Clinical Chemistry and Laboratory Medicine
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- Immunoassays for the detection of IgA antibodies to tissue transglutaminase: significance of multiples of the upper limit of normal and inter-assay correlations
- Effects of biobanking conditions on six antibiotic substances in human serum assessed by a novel evaluation protocol
- Haematology and Coagulation
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- Reference Values and Biological Variations
- Upper reference limits for cerebrospinal fluid total protein and albumin quotient based on a large cohort of control patients: implications for increased clinical specificity
- Reference intervals for bone turnover markers in Spanish premenopausal women
- Cancer Diagnostics
- Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation
- mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients
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- TBX20 loss-of-function mutation associated with familial dilated cardiomyopathy
- Cardiac troponin I release after a basketball match in elite, amateur and junior players
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- Neutrophil CD64 combined with PCT, CRP and WBC improves the sensitivity for the early diagnosis of neonatal sepsis
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- Liquid citrate acidification introduces significant glucose bias and leads to misclassification of patients with diabetes
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- Performance evaluation of low platelet count and platelet clumps detection on Mindray BC-6800 hematology analyzer
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Artikel in diesem Heft
- Frontmatter
- Editorial
- Total error vs. measurement uncertainty: the match continues
- Review
- Application of fatty acid and lipid measurements in neuropsychiatry
- Mini Review
- The Janus faces of acquired angioedema: C1-inhibitor deficiency, lymphoproliferation and autoimmunity
- Opinion Papers
- How to report results of prothrombin and activated partial thromboplastin times
- Useful measures and models for analytical quality management in medical laboratories
- Total error vs. measurement uncertainty: revolution or evolution?
- Genetics and Molecular Diagnostics
- Rapid detection of Mmalton α1-antitrypsin deficiency allele by real-time PCR and melting curves in whole blood, serum and dried blood spot samples
- General Clinical Chemistry and Laboratory Medicine
- Diagnostic and clinical significance of Crohn’s disease-specific pancreatic anti-GP2 and anti-CUZD1 antibodies
- Immunoassays for the detection of IgA antibodies to tissue transglutaminase: significance of multiples of the upper limit of normal and inter-assay correlations
- Effects of biobanking conditions on six antibiotic substances in human serum assessed by a novel evaluation protocol
- Haematology and Coagulation
- Measurement of dabigatran, rivaroxaban and apixaban in samples of plasma, serum and urine, under real life conditions. An international study
- Reference Values and Biological Variations
- Upper reference limits for cerebrospinal fluid total protein and albumin quotient based on a large cohort of control patients: implications for increased clinical specificity
- Reference intervals for bone turnover markers in Spanish premenopausal women
- Cancer Diagnostics
- Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation
- mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients
- Cardiovascular Diseases
- TBX20 loss-of-function mutation associated with familial dilated cardiomyopathy
- Cardiac troponin I release after a basketball match in elite, amateur and junior players
- The role of timely measurement of galectin-3, NT-proBNP, cystatin C and hsTnT in predicting prognosis and heart function after heart transplantation
- Infectious Diseases
- Neutrophil CD64 combined with PCT, CRP and WBC improves the sensitivity for the early diagnosis of neonatal sepsis
- A comparison of three commercial platforms for urinary NGAL in critically ill adults
- Diabetes
- Liquid citrate acidification introduces significant glucose bias and leads to misclassification of patients with diabetes
- Letter to the Editors
- A rare and unstable hemoglobin variant, Hb M Dothan β 25/26 (-GTG), detected by the anomalous cytogram on Sysmex XE-2100
- Hb Hope [β136Gly→Asp] and Hb Grady [α119_120insGluPheThr] compound heterozygosity in a Mauritanian patient
- Falsely elevated ferritin in patients with a high concentration of rheumatoid factor
- Susceptibility of commonly used ferritin assays to the classic hook effect
- Comparison of the Elecsys calcitonin assay with the Immulite 1000 assay. Describing one case with heterophilic antibody interference
- Performance evaluation of low platelet count and platelet clumps detection on Mindray BC-6800 hematology analyzer
- Fetal sex discordance between sequencing-based and real-time PCR non-invasive prenatal test due to a vanishing twin
- Total HIV-1 DNA detection and quantification in peripheral blood by COBAS®AmpliPrep/COBAS® TaqMan® HIV-1 Test, v2.0
- A replacement for the testosterone “sex gap”
- Added value of indirect immunofluorescence intensity of automated antinuclear antibody testing in a secondary hospital setting