Startseite Medizin The baseline serum value of α-amylase is a significant predictor of distance running performance
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The baseline serum value of α-amylase is a significant predictor of distance running performance

  • Giuseppe Lippi EMAIL logo , Gian Luca Salvagno , Elisa Danese , Cantor Tarperi , Antonio La Torre , Gian Cesare Guidi und Federico Schena
Veröffentlicht/Copyright: 2. Oktober 2014
Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine (CCLM) Band 53 Heft 3

Abstract

Background: This study was planned to investigate whether serum α-amylase concentration may be associated with running performance, physiological characteristics and other clinical chemistry analytes in a large sample of recreational athletes undergoing distance running.

Methods: Forty-three amateur runners successfully concluded a 21.1 km half-marathon at 75%–85% of their maximal oxygen uptake (VO2max). Blood was drawn during warm up and 15 min after conclusion of the run.

Results: After correction for body weight change, significant post-run increases were observed for serum values of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, bilirubin, creatine kinase (CK), iron, lactate dehydrogenase (LDH), triglycerides, urea and uric acid, whereas the values of body weight, glomerular filtration rate, total and low density lipoprotein-cholesterol were significantly decreased. The concentration of serum α-amylase was unchanged. In univariate analysis, significant associations with running performance were found for gender, VO2max, training regimen and pre-run serum values of α-amylase, CK, glucose, high density lipoprotein-cholesterol, LDH, urea and uric acid. In multivariate analysis, only VO2max (p=0.042) and baseline α-amylase (p=0.021) remained significant predictors of running performance. The combination of these two variables predicted 71% of variance in running performance. The baseline concentration of serum α-amylase was positively correlated with variation of serum glucose during the trial (r=0.345; p=0.025) and negatively with capillary blood lactate at the end of the run (r=–0.352; p=0.021).

Conclusions: We showed that the baseline serum α-amylase concentration significantly and independently predicts distance running performance in recreational runners.

Keywords: amylase; α-amylase; performance; running; sports
Corresponding author: Prof. Giuseppe Lippi, U.O. Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci, 14, 43126 Parma, Italy, Phone: +39 0521 703050/+39 0521 703791, E-mail: ,

Acknowledgments

The authors sincerely thank the staff of the CeRiSM (Centre for Mountain Sport and Health), who assisted with recruitment and the athletes who generously participated in the study. The study received no external financial support.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Financial support: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2014-8-24
Accepted: 2014-9-9
Published Online: 2014-10-2
Published in Print: 2015-2-1

©2015 by De Gruyter

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  4. The highs and lows of tumor biomarkers: lost illusions
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https://doi.org/10.1515/cclm-2014-0850
Schlagwörter für diesen Artikel
amylase; α-amylase; performance; running; sports

Artikel in diesem Heft

  1. Frontmatter
  2. Editorials
  3. Variable accuracy of home pregnancy tests: truth in advertising?
  4. The highs and lows of tumor biomarkers: lost illusions
  5. Mini Review
  6. Matrix metalloproteinases as biomarkers of disease: updates and new insights
  7. Opinion Papers
  8. Preanalytical quality improvement. In pursuit of harmony, on behalf of European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working group for Preanalytical Phase (WG-PRE)
  9. Colour coding for blood collection tube closures – a call for harmonisation
  10. Harmonization protocols for thyroid stimulating hormone (TSH) immunoassays: different approaches based on the consensus mean value
  11. Genetics and Molecular Diagnostics
  12. Detection of HLA-B*58:01 with TaqMan assay and its association with allopurinol-induced sCADR
  13. General Clinical Chemistry and Laboratory Medicine
  14. Comparison of analytical sensitivity and women’s interpretation of home pregnancy tests
  15. Accuracy of GFR estimating equations combining standardized cystatin C and creatinine assays: a cross-sectional study in Sweden
  16. Immunoassay of thyroid peroxidase autoantibodies: diagnostic performance in automated third generation methods. A multicentre evaluation
  17. Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens
  18. Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots
  19. One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans
  20. Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study
  21. Reference Values and Biological Variations
  22. Salivary morning androstenedione and 17α-OH progesterone levels in childhood and puberty in patients with classic congenital adrenal hyperplasia
  23. The baseline serum value of α-amylase is a significant predictor of distance running performance
  24. Cancer Diagnostics
  25. Urinary thiosulfate as failed prostate cancer biomarker – an exemplary multicenter re-evaluation study
  26. Clinical utility of determining tumor markers in patients with signs and symptoms of cancer
  27. Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients
  28. The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer
  29. Cardiovascular Diseases
  30. Predictive value for death and rehospitalization of 30-day postdischarge B-type natriuretic peptide (BNP) in elderly patients with heart failure. Sub-analysis of Italian RED Study
  31. Letters to the Editors
  32. Pre-analytical stability of 25(OH)-vitamin D in primary collection tubes
  33. Effects of lipemia on osmolality in native lipemic material and intravenous lipid emulsion added sera
  34. Does creatinine analytical performance support robust identification of acute kidney injury within individual laboratories in a region
  35. High serum amylase levels may reflect a wide spectrum of health benefits
  36. Optimal cut-off concentration for a faecal immunochemical test for haemoglobin by Hemo Techt NS-Plus C15 system for the colorectal cancer screening
  37. MTHFR C677T allelic variant is not associated with plasma and cerebrospinal fluid homocysteine in amyotrophic lateral sclerosis
  38. Analytical assessment of bone serum markers in patients suffering from spina bifida
  39. Serum concentrations and urinary excretion of homogentisic acid and tyrosine in normal subjects
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