Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients
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Joanna Szkandera
Abstract
Background: Recent evidence indicates toward a role of uric acid (UA) as a potential antioxidant. Elevated UA levels were shown to be associated with better survival in various malignancies. The aim of the present study was to evaluate the prognostic relevance of pre-operative UA levels on cancer-specific survival (CSS) in soft-tissue sarcoma (STS) patients who underwent curative surgical resection.
Methods: Three hundred and fifty-seven patients with STS were included in the study. Pre-operative serum UA level was measured using an enzymatic colorimetric assay. The effect of UA levels on CSS was analyzed using Kaplan-Meier curves. To further evaluate the prognostic impact of UA levels, univariate and multivariate Cox proportional models were calculated.
Results: Among the 357 STS patients, cancer-related deaths occurred in 20 (24.7%) of 81 patients with a serum UA level <279.6 µmol/L and in 36 (13%) of 276 patients with a UA level ≥279.6 µmol/L. In univariate analysis, elevated UA levels were significantly associated with increased CSS in STS patients [hazard ratio (HR) 0.44, 95% confidence interval (CI) 0.26–0.77, p=0.004]. Furthermore, elevated UA levels remain a significant factor for better CCS in multivariate analysis (HR 0.42, 95% CI 0.23–0.75, p=0.003).
Conclusions: Our study is the first one to demonstrate that higher UA levels are associated with positive clinical outcome in STS patients. UA levels are a simple and cost-effective test for the assessment of the prognosis of STS patients.
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©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorials
- Variable accuracy of home pregnancy tests: truth in advertising?
- The highs and lows of tumor biomarkers: lost illusions
- Mini Review
- Matrix metalloproteinases as biomarkers of disease: updates and new insights
- Opinion Papers
- Preanalytical quality improvement. In pursuit of harmony, on behalf of European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working group for Preanalytical Phase (WG-PRE)
- Colour coding for blood collection tube closures – a call for harmonisation
- Harmonization protocols for thyroid stimulating hormone (TSH) immunoassays: different approaches based on the consensus mean value
- Genetics and Molecular Diagnostics
- Detection of HLA-B*58:01 with TaqMan assay and its association with allopurinol-induced sCADR
- General Clinical Chemistry and Laboratory Medicine
- Comparison of analytical sensitivity and women’s interpretation of home pregnancy tests
- Accuracy of GFR estimating equations combining standardized cystatin C and creatinine assays: a cross-sectional study in Sweden
- Immunoassay of thyroid peroxidase autoantibodies: diagnostic performance in automated third generation methods. A multicentre evaluation
- Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens
- Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots
- One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans
- Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study
- Reference Values and Biological Variations
- Salivary morning androstenedione and 17α-OH progesterone levels in childhood and puberty in patients with classic congenital adrenal hyperplasia
- The baseline serum value of α-amylase is a significant predictor of distance running performance
- Cancer Diagnostics
- Urinary thiosulfate as failed prostate cancer biomarker – an exemplary multicenter re-evaluation study
- Clinical utility of determining tumor markers in patients with signs and symptoms of cancer
- Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients
- The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer
- Cardiovascular Diseases
- Predictive value for death and rehospitalization of 30-day postdischarge B-type natriuretic peptide (BNP) in elderly patients with heart failure. Sub-analysis of Italian RED Study
- Letters to the Editors
- Pre-analytical stability of 25(OH)-vitamin D in primary collection tubes
- Effects of lipemia on osmolality in native lipemic material and intravenous lipid emulsion added sera
- Does creatinine analytical performance support robust identification of acute kidney injury within individual laboratories in a region
- High serum amylase levels may reflect a wide spectrum of health benefits
- Optimal cut-off concentration for a faecal immunochemical test for haemoglobin by Hemo Techt NS-Plus C15 system for the colorectal cancer screening
- MTHFR C677T allelic variant is not associated with plasma and cerebrospinal fluid homocysteine in amyotrophic lateral sclerosis
- Analytical assessment of bone serum markers in patients suffering from spina bifida
- Serum concentrations and urinary excretion of homogentisic acid and tyrosine in normal subjects
Articles in the same Issue
- Frontmatter
- Editorials
- Variable accuracy of home pregnancy tests: truth in advertising?
- The highs and lows of tumor biomarkers: lost illusions
- Mini Review
- Matrix metalloproteinases as biomarkers of disease: updates and new insights
- Opinion Papers
- Preanalytical quality improvement. In pursuit of harmony, on behalf of European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working group for Preanalytical Phase (WG-PRE)
- Colour coding for blood collection tube closures – a call for harmonisation
- Harmonization protocols for thyroid stimulating hormone (TSH) immunoassays: different approaches based on the consensus mean value
- Genetics and Molecular Diagnostics
- Detection of HLA-B*58:01 with TaqMan assay and its association with allopurinol-induced sCADR
- General Clinical Chemistry and Laboratory Medicine
- Comparison of analytical sensitivity and women’s interpretation of home pregnancy tests
- Accuracy of GFR estimating equations combining standardized cystatin C and creatinine assays: a cross-sectional study in Sweden
- Immunoassay of thyroid peroxidase autoantibodies: diagnostic performance in automated third generation methods. A multicentre evaluation
- Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens
- Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots
- One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans
- Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study
- Reference Values and Biological Variations
- Salivary morning androstenedione and 17α-OH progesterone levels in childhood and puberty in patients with classic congenital adrenal hyperplasia
- The baseline serum value of α-amylase is a significant predictor of distance running performance
- Cancer Diagnostics
- Urinary thiosulfate as failed prostate cancer biomarker – an exemplary multicenter re-evaluation study
- Clinical utility of determining tumor markers in patients with signs and symptoms of cancer
- Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients
- The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer
- Cardiovascular Diseases
- Predictive value for death and rehospitalization of 30-day postdischarge B-type natriuretic peptide (BNP) in elderly patients with heart failure. Sub-analysis of Italian RED Study
- Letters to the Editors
- Pre-analytical stability of 25(OH)-vitamin D in primary collection tubes
- Effects of lipemia on osmolality in native lipemic material and intravenous lipid emulsion added sera
- Does creatinine analytical performance support robust identification of acute kidney injury within individual laboratories in a region
- High serum amylase levels may reflect a wide spectrum of health benefits
- Optimal cut-off concentration for a faecal immunochemical test for haemoglobin by Hemo Techt NS-Plus C15 system for the colorectal cancer screening
- MTHFR C677T allelic variant is not associated with plasma and cerebrospinal fluid homocysteine in amyotrophic lateral sclerosis
- Analytical assessment of bone serum markers in patients suffering from spina bifida
- Serum concentrations and urinary excretion of homogentisic acid and tyrosine in normal subjects
