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The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer

  • Michael Stotz EMAIL logo , Joanna Szkandera , Tatjana Stojakovic , Julia Seidel , Hellmut Samonigg , Peter Kornprat , Renate Schaberl-Moser , Fridericke Seggewies , Gerald Hoefler , Armin Gerger and Martin Pichler
Published/Copyright: November 8, 2014
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 53 Issue 3

Abstract

Background: Intra-tumoral macrophages have been involved as important players in the pathogenesis and progression of cancer. Recently, inflammatory parameters of the systemic inflammatory response have also been proposed as usefully prognostic biomarkers. One of these, the lymphocyte to monocyte ratio (LMR) in peripheral blood has been shown as a prognostic factor in hematologic and some solid tumors. In this study we analyzed for the first time the prognostic value of LMR in a large middle European cohort of pancreatic cancer (PC) patients.

Methods: Data from 474 consecutive patients with ductal adenocarcinoma of the pancreas were evaluated retrospectively. Cancer-specific survival (CSS) was analyzed using the Kaplan-Meier method. To further evaluate the prognostic significance of the LMR, univariate and multivariate Cox regression models were calculated.

Results: Increased LMR at diagnosis was significantly associated with well-established prognostic factors, including high tumor stage and tumor grade (p<0.05). In univariate analysis, we observed that an increased LMR was a significant factor for better CSS in PC patients (HR 0.70; 95% CI 0.57–0.85; p<0.001). In multivariate analysis including age, Karnofsky Index, tumor grade, tumor stage, administration of chemotherapy, LMR and surgical resection, we confirmed increased LMR as an independent prognostic factor for CSS (HR 0.81; 95% CI 0.66–0.99; p=0.04).

Conclusions: In conclusion, we identified LMR as an independent prognostic factor in PC patients. Our results indicate that the LMR might represent a novel and useful marker for patient stratification in PC management.

Keywords: inflammation; monocytes; pancreatic cancer; prognosis
Corresponding author: Michael Stotz, Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria, Phone: +43 316 385 13115, Fax: +43 316 385 13355, E-mail: ; and Research Unit Genetic Epidemiology and Pharmacogenetics, Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria

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Received: 2014-4-25
Accepted: 2014-10-13
Published Online: 2014-11-8
Published in Print: 2015-2-1

©2015 by De Gruyter

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  28. The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer
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https://doi.org/10.1515/cclm-2014-0447
Keywords for this article
inflammation; monocytes; pancreatic cancer; prognosis

Articles in the same Issue

  1. Frontmatter
  2. Editorials
  3. Variable accuracy of home pregnancy tests: truth in advertising?
  4. The highs and lows of tumor biomarkers: lost illusions
  5. Mini Review
  6. Matrix metalloproteinases as biomarkers of disease: updates and new insights
  7. Opinion Papers
  8. Preanalytical quality improvement. In pursuit of harmony, on behalf of European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working group for Preanalytical Phase (WG-PRE)
  9. Colour coding for blood collection tube closures – a call for harmonisation
  10. Harmonization protocols for thyroid stimulating hormone (TSH) immunoassays: different approaches based on the consensus mean value
  11. Genetics and Molecular Diagnostics
  12. Detection of HLA-B*58:01 with TaqMan assay and its association with allopurinol-induced sCADR
  13. General Clinical Chemistry and Laboratory Medicine
  14. Comparison of analytical sensitivity and women’s interpretation of home pregnancy tests
  15. Accuracy of GFR estimating equations combining standardized cystatin C and creatinine assays: a cross-sectional study in Sweden
  16. Immunoassay of thyroid peroxidase autoantibodies: diagnostic performance in automated third generation methods. A multicentre evaluation
  17. Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens
  18. Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots
  19. One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans
  20. Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study
  21. Reference Values and Biological Variations
  22. Salivary morning androstenedione and 17α-OH progesterone levels in childhood and puberty in patients with classic congenital adrenal hyperplasia
  23. The baseline serum value of α-amylase is a significant predictor of distance running performance
  24. Cancer Diagnostics
  25. Urinary thiosulfate as failed prostate cancer biomarker – an exemplary multicenter re-evaluation study
  26. Clinical utility of determining tumor markers in patients with signs and symptoms of cancer
  27. Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients
  28. The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer
  29. Cardiovascular Diseases
  30. Predictive value for death and rehospitalization of 30-day postdischarge B-type natriuretic peptide (BNP) in elderly patients with heart failure. Sub-analysis of Italian RED Study
  31. Letters to the Editors
  32. Pre-analytical stability of 25(OH)-vitamin D in primary collection tubes
  33. Effects of lipemia on osmolality in native lipemic material and intravenous lipid emulsion added sera
  34. Does creatinine analytical performance support robust identification of acute kidney injury within individual laboratories in a region
  35. High serum amylase levels may reflect a wide spectrum of health benefits
  36. Optimal cut-off concentration for a faecal immunochemical test for haemoglobin by Hemo Techt NS-Plus C15 system for the colorectal cancer screening
  37. MTHFR C677T allelic variant is not associated with plasma and cerebrospinal fluid homocysteine in amyotrophic lateral sclerosis
  38. Analytical assessment of bone serum markers in patients suffering from spina bifida
  39. Serum concentrations and urinary excretion of homogentisic acid and tyrosine in normal subjects
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