Article
Licensed
Unlicensed
Requires Authentication
Association of PBEF gene polymorphisms with acute lung injury, sepsis, and pneumonia in a northeastern Chinese population
-
Yaxin Liu
Published/Copyright:
June 23, 2012
Abstract
Background: Several studies have suggested that pre-B-cell colony-enhancing factor (PBEF) gene polymorphisms are associated with susceptibility to and prognosis of acute lung injury (ALI) in several populations of Caucasians. The aim of this study was to detect the distribution of PBEF alleles and to evaluate any potential relationship between PBEF polymorphisms and ALI, sepsis, and pneumonia in the Han population of Northeast China.
Methods: Genotyping of two PBEF promoter single-nucleotide polymorphisms (SNPs), rs61330082 (C–1535T) and rs9770242 (T–1001G), were performed in patients with ALI (n=130), sepsis alone (n=107), bacterial pneumonia (n=195) and 150 healthy volunteers using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results: We found no variation in the T-1001G allele of PBEF. The homozygous TT genotype was the only genotype. This result is different from that observed in Caucasians. The frequency of the -1543T allele was lower in patients with ALI and sepsis than that in healthy subjects ALI vs. healthy controls: OR=0.60, 95% CI 0.43–0.84, p=0.003; and sepsis vs. healthy controls: OR=0.69, 95% CI 0.49–0.99, p=0.04, respectively). The frequency of TT genotype of -1543T was significantly lower in patients with ALI and sepsis than in healthy subjects (ALI vs. healthy controls: OR=0.23, 95% CI 0.10–0.54, p=0.001; and sepsis vs. healthy controls: OR=0.36, 95% CI 0.15–0.83, p=0.02, respectively).
Conclusions: This study suggested that -1543T allele might be a protective factor for ALI and sepsis, but it apparently had no connection with pneumonia in northeastern Chinese Han patients.
Keywords: acute lung injury; bacterial pneumonia; gene polymorphism; pre-B-cell colony-enhancing factor (PBEF); sepsis
Received: 2012-04-13
Accepted: 2012-05-20
Published Online: 2012-06-23
Published in Print: 2012-11-01
©2012 by Walter de Gruyter Berlin Boston
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Congress Abstracts
- 44th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology
- Masthead
- Masthead
- Editorials
- Tumor biomarkers: PSA and beyond
- Error reporting in transfusion medicine: an important tool to improve patient safety
- The measurement of 25-hydroxy vitamin D – an analytical challenge
- Reviews
- Kallikrein-related peptidases (KLKs): a gene family of novel cancer biomarkers
- Exhaled breath analysis for early cancer detection: principle and progress in direct mass spectrometry techniques
- γ′ Fibrinogen as a novel marker of thrombotic disease
- Mini Review
- Revaluating serum ferritin as a marker of body iron stores in the traceability era
- Genetics and Molecular Diagnostics
- Association of PBEF gene polymorphisms with acute lung injury, sepsis, and pneumonia in a northeastern Chinese population
- General Clinical Chemistry and Laboratory Medicine
- Brazilian laboratory indicators program
- Error reporting in transfusion medicine at a tertiary care centre: a patient safety initiative
- Application of mathematical models of system uncertainty to evaluate the utility of assay calibration protocols
- 25-Hydroxyvitamin D testing: challenging the performance of current automated immunoassays
- Analytical validation of the Roche 25-OH Vitamin D Total assay
- The new Roche Vitamin D Total assay: fit for its purpose?
- Improvement of a prenatal screening program for trisomy 18 in the first trimester of gestation
- Stability of osteopontin in plasma and serum
- Is there a suitable point-of-care glucose meter for tight glycemic control? Evaluation of one home-use and four hospital-use meters in an intensive care unit
- Cancer Diagnostics
- Rapid elimination kinetics of free PSA or human kallikrein-related peptidase 2 after initiation of gonadotropin-releasing hormone-antagonist treatment of prostate cancer: potential for rapid monitoring of treatment responses
- Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis
- Cardiovascular Diseases
- The combined use of neutrophil gelatinase-associated lipocalin and brain natriuretic peptide improves risk stratification in pediatric cardiac surgery
- Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy
- The high-sensitivity cardiac troponin T assay is superior to its previous assay generation for prediction of 90-day clinical outcome in ischemic stroke
- Letters to the Editor
- Evaluation of the cross-reactivity of 25-hydroxyvitamin D2 on seven commercial immunoassays on native samples
- Measurement of 25-hydroxyvitamin vitamin D by liquid chromatography tandem-mass spectrometry with comparison to automated immunoassays
- Analytical evaluation of a new automated protein binding assay to determine 25-hydroxyvitamin D concentrations
- Mindray BS-800M1: a new clinical chemistry system with a flexible technology meeting quality performances
- Association of urinary albumin and serum high molecular weight-adiponectin with metabolic syndrome in patients with essential hypertension
- Measurement of nitrite in plasma and serum: still a challenging analytical task
- Association between serum γ-glutamyltransferase and pulmonary dysfunction
- Serum ferritin concentrations predict incidence of metabolic syndrome in rural Korean adults
- Homocysteine, folic acid and vitamin B12 levels in females with severe acne vulgaris
Keywords for this article
acute lung injury;
bacterial pneumonia;
gene polymorphism;
pre-B-cell colony-enhancing factor (PBEF);
sepsis
Articles in the same Issue
- Congress Abstracts
- 44th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology
- Masthead
- Masthead
- Editorials
- Tumor biomarkers: PSA and beyond
- Error reporting in transfusion medicine: an important tool to improve patient safety
- The measurement of 25-hydroxy vitamin D – an analytical challenge
- Reviews
- Kallikrein-related peptidases (KLKs): a gene family of novel cancer biomarkers
- Exhaled breath analysis for early cancer detection: principle and progress in direct mass spectrometry techniques
- γ′ Fibrinogen as a novel marker of thrombotic disease
- Mini Review
- Revaluating serum ferritin as a marker of body iron stores in the traceability era
- Genetics and Molecular Diagnostics
- Association of PBEF gene polymorphisms with acute lung injury, sepsis, and pneumonia in a northeastern Chinese population
- General Clinical Chemistry and Laboratory Medicine
- Brazilian laboratory indicators program
- Error reporting in transfusion medicine at a tertiary care centre: a patient safety initiative
- Application of mathematical models of system uncertainty to evaluate the utility of assay calibration protocols
- 25-Hydroxyvitamin D testing: challenging the performance of current automated immunoassays
- Analytical validation of the Roche 25-OH Vitamin D Total assay
- The new Roche Vitamin D Total assay: fit for its purpose?
- Improvement of a prenatal screening program for trisomy 18 in the first trimester of gestation
- Stability of osteopontin in plasma and serum
- Is there a suitable point-of-care glucose meter for tight glycemic control? Evaluation of one home-use and four hospital-use meters in an intensive care unit
- Cancer Diagnostics
- Rapid elimination kinetics of free PSA or human kallikrein-related peptidase 2 after initiation of gonadotropin-releasing hormone-antagonist treatment of prostate cancer: potential for rapid monitoring of treatment responses
- Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis
- Cardiovascular Diseases
- The combined use of neutrophil gelatinase-associated lipocalin and brain natriuretic peptide improves risk stratification in pediatric cardiac surgery
- Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy
- The high-sensitivity cardiac troponin T assay is superior to its previous assay generation for prediction of 90-day clinical outcome in ischemic stroke
- Letters to the Editor
- Evaluation of the cross-reactivity of 25-hydroxyvitamin D2 on seven commercial immunoassays on native samples
- Measurement of 25-hydroxyvitamin vitamin D by liquid chromatography tandem-mass spectrometry with comparison to automated immunoassays
- Analytical evaluation of a new automated protein binding assay to determine 25-hydroxyvitamin D concentrations
- Mindray BS-800M1: a new clinical chemistry system with a flexible technology meeting quality performances
- Association of urinary albumin and serum high molecular weight-adiponectin with metabolic syndrome in patients with essential hypertension
- Measurement of nitrite in plasma and serum: still a challenging analytical task
- Association between serum γ-glutamyltransferase and pulmonary dysfunction
- Serum ferritin concentrations predict incidence of metabolic syndrome in rural Korean adults
- Homocysteine, folic acid and vitamin B12 levels in females with severe acne vulgaris
