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Minor improvement of venous blood specimen collection practices in primary health care after a large-scale educational intervention

  • Karin Bölenius EMAIL logo , Johan Söderberg , Johan Hultdin , Marie Lindkvist , Christine Brulin and Kjell Grankvist
Published/Copyright: August 7, 2012

Abstract

Background: Venous blood specimen collection is a common health care practice that has to follow strict guidelines, non-compliance among sampling staff may compromise patient safety. We evaluated a large-scale 2 h educational intervention that emphasised guideline adherence to assess possible improvements of venous blood specimen collection practices.

Methods: Blood specimen haemolysis is usually caused by inadequate venous blood specimen collection and handling, reflecting overall pre-analytical handling. We monitored haemolysis of serum samples with haemolysis index corresponding to ≥150 mg/L of free haemoglobin for specimens sent from 11 primary health care centres and analysed on a Vitros 5,1 clinical chemistry analyser before (2008, n=6652 samples) and after (2010, n=6121 samples) the intervention.

Results: The total percentage of haemolysed specimens was 11.8% compared to 10.5% (p=0.022) before the intervention. As groups, rural primary health care centres demonstrated a significant reduction [Odds ratios (OR)=0.744] of haemolysed specimens after intervention, whereas urban primary health care centres demonstrated a significant increase (OR=1.451) of haemolysis.

Conclusions: A large-scale 2 h educational intervention to make venous blood specimen collection staff comply with guideline practices had minor effects on collection practices. Educational interventions may be effective in wards/care centres demonstrating venous blood specimen collection practices with larger deviations from guidelines.


Corresponding author: Karin Bölenius, Department of Nursing, Umeå University, Building A, 4th floor, 901 87 Umeå, Sweden Phone: +46 09 7859115, Fax: +46 90 7869851

This work would not have been possible without Jenny Ekman and Annika Wästerby who retrieved haemolysis data and the laboratory instructors Susanne Hermansson, Ann-Britt Lindström, Marie Backlund and Marie Lundgren who performed the educational intervention. We would like to thank the Faculty of Medicine, Umeå University, Umeå, Sweden, the Swedish National Board of Health and Welfare, Sweden and Västerbotten County Council in Sweden for research funding.

Conflict of interest statement

Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Authors’ contributions: KB, JS, CB and KG proposed the original idea for the study. KB and JH collected the data and executed the statistical analyses together with ML. KB drafted the manuscript and all the authors read the manuscript critically for important intellectual content and approved the final manuscript.

References

1. Gagliardi AR, Brouwers MC, Palda VA, Lemieux-Charles L, Grimshaw JM. An exploration of how guideline developer capacity and guideline implementability influence implementation and adoption: study protocol. Implement Sci 2009;4:36.10.1186/1748-5908-4-36http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000268171900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar PubMed

2. Swedish National Board of Health and Welfare. (SFS 2010:659). Availablefrom: http://62.95.69.3/SFSdoc/10/100659.PDF. Accessed 2 March, 2012.Search in Google Scholar

3. Grol R, Grimshaw J. From best evidence to best practice: effective implementation of change in patients’ care. Lancet 2003;362:1225–30.10.1016/S0140-6736(03)14546-1Search in Google Scholar PubMed

4. Söderberg J, Grankvist K, Brulin C, Wallin O. Incident reporting practices in the pre-analytical phase: low reported frequencies in the primary health care setting. Scand J Clin Lab Invest 2009;69:731–5.10.3109/00365510903007018http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000272492300002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar

5. Söderberg J, Wallin O, Grankvist K, Brulin C. Is the test result correct? A questionnaire study of blood collection practices in primary health care. J Eval Clin Pract 2010;16:707–11.10.1111/j.1365-2753.2009.01179.xhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000279901700007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar PubMed

6. Söderberg J, Brulin C, Grankvist K, Wallin O. Pre-analytical errors in primary healthcare: a questionnaire study of information search procedures, test request management and test tube labelling. Clin Chem Lab Med 2009;47:195–201.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000263656400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar

7. Wallin O, Söderberg J, Van Guelpen B, Stenlund H, Grankvist K, Brulin C. Pre-analytical venous blood sampling practices demand improvement – a survey of test-request management, test-tube labelling and information search procedures. Clin Chim Acta 2008;391:91–7.10.1016/j.cca.2008.02.016http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000255846000016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar

8. Wallin O, Söderberg J, Van Guelpen B, Stenlund H, Grankvist K, Brulin C. Blood sample collection and patient identification demand improvement: a questionnaire study of pre-analytical practices in hospital wards and laboratories. Scand J Caring Sci 2010;24:581–91.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000281000800020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111/j.1471-6712.2009.00753.xSearch in Google Scholar

9. Wallin O. Pre-analytical errors in hospitals: implications for quality improvement of blood sample collection. [doctoral thesis]. Umeå: Umeå Universitet, 2008.Search in Google Scholar

10. The Handbook for Healthcare. Available from: http://www.vardhandboken.se/In-English/. Accessed 18 January, 2012.Search in Google Scholar

11. Lippi G, Blanckaert N, Bonini P, Green S, Kitchen S, Palicka V, et al. Haemolysis: an overview of the leading cause of unsuitable specimens in clinical laboratories. Clin Chem Lab Med 2008;46:764–72.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000257542800003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar PubMed

12. Söderberg J, Jonsson PA, Wallin O, Grankvist K, Hultdin J. Haemolysis index – an estimate of pre-analytical quality in primary health care. Clin Chem Lab Med 2009;47:940–4.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000268507800007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar PubMed

13. Laga A, Cheves T, Maroto S, Coutts M, Sweeney J. The suitability of hemolyzed specimens for compatibility testing using automated technology. Transfusion 2008;48:1713–20.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000258077800027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111/j.1537-2995.2008.01741.xSearch in Google Scholar PubMed

14. Guder W, da Fonseca-Wollheim F, Heil W, Schmitt Y, Töpfer G, Wisser H, et al. The haemolytic, icteric and lipemic sample recommendations regarding their recognition and prevention of clinically relevant interferences. Lab Med 2000;24:357–64.10.1515/labm.2000.24.8.357Search in Google Scholar

15. Plebani M, Piva E. Medical errors: pre-analytical issue in patient safety. J Med Biochem 2010;29:310–4.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000282677600011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.2478/v10011-010-0039-2Search in Google Scholar

16. Ong ME, Chan YH, Lim CS. Reducing blood sample hemolysis at a tertiary hospital emergency department. Am J Med 2009;122:1054.e1–6.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000271098900018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1016/j.amjmed.2009.04.024Search in Google Scholar

17. Kirchner MJ, Funes VA, Adzet CB, Clar MV, Escuer MI, Girona JM, et al. Quality indicators and specifications for key processes in clinical laboratories: a preliminary experience. Clin Chem Lab Med 2007;45:672–7.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000247005900018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar PubMed

18. Kennedy C, Angermuller S, King R, Noviello S, Walker J, Warden J, et al. A comparison of hemolysis rates using intravenous catheters versus venipuncture tubes for obtaining blood samples. J Emerg Nurs 1996;22:566–9.10.1016/S0099-1767(96)80213-3Search in Google Scholar PubMed

19. Munnix IC, Schellart M, Gorissen C, Kleinveld H. Factors reducing hemolysis rates in blood samples from the emergency department. Clin Chem Lab Med 2011;49:157–8.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000286418300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar PubMed

20. Cox SR, Dages JH, Jarjoura D, Hazelett S. Blood samples drawn from IV catheters have less hemolysis when 5-mL (vs 10-mL) collection tubes are used. J Emerg Nurs 2004;30:529–33.10.1016/j.jen.2004.10.004Search in Google Scholar PubMed

21. Bölenius K, Brulin C, Grankvist K, Lindkvist M, Söderberg J. A content validated questionnaire for assessment of self-reported venous blood sampling practices. BMC Res Notes 2012;5:39.10.1186/1756-0500-5-39Search in Google Scholar PubMed PubMed Central

22. Kahn SE, Watkins BF, Bermes EW, Jr. An evaluation of aspectrophotometric scanning technique for measurement of plasma hemoglobin. Ann Clin Lab Sci 1981;11:126–31.Search in Google Scholar PubMed

23. Västerbottens Läns Landsting. Provtagningsanvisningar Laboratoriemedicin VLL (in Swedish). Available from: https://webappl.vll.se/provtagningsanvisningar. Accessed 2 March, 2012.Search in Google Scholar

24. Clinical and Laboratory Standards Institute: Procedures for the collection of diagnostic blood specimens by venipuncture. Approved Standard. CLSI document H3-A6 6th ed. Wayne: CLSI, 2007.Search in Google Scholar

25. Tanabe P, Kyriacou DN, Garland F. Factors affecting the risk of blood bank specimen hemolysis. Acad Emerg Med 2003;10:897–900.10.1111/j.1553-2712.2003.tb00637.xSearch in Google Scholar PubMed

26. Thomas L. Haemolysis as influence and interference factor. Biochim Clin 2002;26:95.Search in Google Scholar

27. Lippi G, Salvagno GL, Montagnana M, Brocco G, Guidi GC. Influence of hemolysis on routine clinical chemistry testing. Clin Chem Lab Med 2006;44:311–6.10.1515/CCLM.2006.054Search in Google Scholar PubMed

28. Grant MS. The effect of blood drawing techniques and equipment on the hemolysis of ED laboratory blood samples. J Emerg Nurs 2003;29:116–21.10.1067/men.2003.66Search in Google Scholar PubMed

29. Fang L, Fang SH, Chung YH, Chien ST. Collecting factors related to the haemolysis of blood specimens. J Clin Nurs 2008;17:2343–51.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000258405800014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111/j.1365-2702.2006.02057.xSearch in Google Scholar PubMed

30. Carraro P, Servidio G, Plebani M. Hemolyzed specimens: a reason for rejection or a clinical challenge? Clin Chem 2000;46:306.10.1093/clinchem/46.2.306Search in Google Scholar PubMed

31. Jamtvedt G, Young JM, Kristoffersen DT, O’Brien MA, Oxman AD. Audit and feedback: effects on professional practice and health care outcomes. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD000259.pub2/pdf. Accessed 2 March, 2012.10.1002/14651858.CD000259.pub2/pdf.Accessed2Search in Google Scholar

32. Lippi G, Plebani M, Di Somma S, Cervellin G. Hemolyzed specimens: a major challenge for emergency departments and clinical laboratories. Crit Rev Clin Lab Sci 2011;48:143–53.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000294492400003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.3109/10408363.2011.600228Search in Google Scholar PubMed

33. Lippi G, Salvagno GL, Montagnana GB, Guidi GC. Influence of short-term venous stasis on clinical chemistry testing. Clin Chem Lab Med 2005;43:869–75.10.1515/CCLM.2005.146Search in Google Scholar PubMed

34. Lima-Oliveira G, Lippi G, Salvagno GL, Montagnana M, Scartezini M, Guidi GC, et al. Transillumination: a new tool to eliminate the impact of venous stasis during the procedure for the collection of diagnostic blood specimens for routine haematological testing. Int J Lab Hematol 2011;33:457–62.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000294131200005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111/j.1751-553X.2011.01305.xSearch in Google Scholar

35. Ernst DJ. Flawless phlebotomy: becoming a great collector. Nursing 1995;25:54.10.1097/00152193-199510000-00022Search in Google Scholar PubMed

36. Ovretveit J, Gustafson D. Evaluation of quality improvement programmes. Qual Saf Health Care 2002;11:270–5.10.1136/qhc.11.3.270Search in Google Scholar PubMed

37. Ovretveit J, Gustafson D. Improving the quality of health care – using research to inform quality programmes. Brit Med J 2003;326:759–61.10.1136/bmj.326.7392.759Search in Google Scholar

38. Landefeld CS, Shojania KG, Auerbach AD. Should we use large scale healthcare interventions without clear evidence that benefits outweigh costs and harms? No. BMJ 2008;336:1277.10.1136/bmj.a144http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000256705900028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar PubMed

39. What are Large Scale Intervention? Available from: http://www.largescaleinterventions.com/english%20version/intro%20What%20is%20LSI.htm. Accessed 18 January, 2012.Search in Google Scholar

40. Mittman BS, Tonesk X, Jacobson PD. Implementing clinical practice guidelines: social influence strategies and practitioner behavior change. Qual Rev Bull 1992;18:413.10.1016/S0097-5990(16)30567-XSearch in Google Scholar

41. Gagliardi AR, Brouwers MC, Palda VA, Lemieux-Charles L, Grimshaw JM. How can we improve guideline use? A conceptual framework of implementability. Implement Sci 2011;6:26.10.1186/1748-5908-6-26http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000289293800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar PubMed PubMed Central

42. Fink R, Thompson CJ, Bonnes D. Overcoming barriers and promoting the use of research in practice. J Nurs Admin 2005;35:121–9.10.1097/00005110-200503000-00005Search in Google Scholar PubMed

43. Franke AL, Smit MC, de Veer AJ, Mistiaen P. Factors influencing the implementation of clinical guidelines for health care professionals: a systematic meta-review. Med Inform Decis Mak 2008;8:38.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000259819400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1186/1472-6947-8-38Search in Google Scholar PubMed PubMed Central

44. Lippi G, Sonntag O, Plebani M. Appropriate labelling of blood collection tubes: a step ahead towards patient’s safety. Clin Chem Lab Med 2011;49:1921–3.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000299856700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Search in Google Scholar

45. Grol RP, Bosch MC, Hulscher ME, Eccles MP, Wensing M. Planning and studying improvement in patient care: the use of theoretical perspectives. Milbank Q 2007;85:93–138.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000244341800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1111/j.1468-0009.2007.00478.xSearch in Google Scholar PubMed PubMed Central

Received: 2012-03-14
Accepted: 2012-07-03
Published Online: 2012-08-07
Published in Print: 2013-02-01

©2013 by Walter de Gruyter Berlin Boston

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