Abstract
Nanoparticles are used in medicine to deliver drugs, for imaging, for vaccination and for local heating of tissue (tumor thermotherapy). If malignant tissue shall be addressed, it is of prime importance to direct the nanoparticles to their target. This can be accomplished by making use of physical effects (e.g., the EPR effect: enhanced permeation and retention) or by chemical modification of the nanoparticles to specifically recognize cells or tissues. The efficiency of the targeting can be assessed by in vitro cell culture experiments and also in vivo in animal experiments. As they are closest to the practical clinical application, in vivo imaging methods are particularly suitable to monitor the targeting. In general, a limited colloid-chemical stability of the nanoparticles in a biological environment and the formation of a protein corona around the nanoparticle may constrain their targeting ability. The current state of such targeting strategies is reviewed and discussed.
We thank the Deutsche Forschungsgemeinschaft for generous finding of our work within the framework of the Transregional Collaborative Research Center (TRR60): Mutual interaction of chronic viruses with cells of the immune system: from fundamental research to immunotherapy and vaccination, and the priority program 1313: Biological responses to nanoparticles.
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Artikel in diesem Heft
- Masthead
- Masthead
- Editorial
- Milestones in Biomaterials Research: Special Issue on the occasion of the 20th anniversary of the German Society of Biomaterials
- Reviews
- Biomaterials – a history of 7000 years
- Biomaterials for enhancement of bone healing in osteoporotic fractures
- Surface functionalization of biomaterials with tissue-inductive artificial extracellular matrices
- Cell-material interaction
- Biological targeting with nanoparticles: state of the art
- Design and fabrication of scaffold-based tissue engineering
- Special Issue: Nanosafety (Part 2)
- Review
- The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design
- Highlights
- Antimicrobial efficacy, cytotoxicity, and ion release of mixed metal (Ag, Cu, Zn, Mg) nanoparticle polymer composite implant material
- Silver and carbon nanoparticles toxicity in sea urchin Paracentrotus lividus embryos
- Letter
- Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro
Artikel in diesem Heft
- Masthead
- Masthead
- Editorial
- Milestones in Biomaterials Research: Special Issue on the occasion of the 20th anniversary of the German Society of Biomaterials
- Reviews
- Biomaterials – a history of 7000 years
- Biomaterials for enhancement of bone healing in osteoporotic fractures
- Surface functionalization of biomaterials with tissue-inductive artificial extracellular matrices
- Cell-material interaction
- Biological targeting with nanoparticles: state of the art
- Design and fabrication of scaffold-based tissue engineering
- Special Issue: Nanosafety (Part 2)
- Review
- The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design
- Highlights
- Antimicrobial efficacy, cytotoxicity, and ion release of mixed metal (Ag, Cu, Zn, Mg) nanoparticle polymer composite implant material
- Silver and carbon nanoparticles toxicity in sea urchin Paracentrotus lividus embryos
- Letter
- Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro