Abstract
The main goal of the study was to develop a model of the degree of surface porosity of a biomaterial intended for implants. The model was implemented using MATLAB. A computer simulation was carried out based on the developed model, which resulted in a two-dimensional image of the modelled surface. Then, an algorithm for computerised image analysis of the surface of the actual oxide bioceramic layer was developed, which enabled determining its degree of porosity. In order to obtain the confocal micrographs of a few areas of the biomaterial, measurements were performed using the LEXT OLS4000 confocal laser microscope. The image analysis was carried out using MountainsMap Premium and SPIP. The obtained results allowed determining the input parameters of the program, on the basis of which porous biomaterial surface images were generated. The last part of the study involved verification of the developed model. The modelling method was tested by comparing the obtained results with the experimental data obtained from the analysis of surface images of the test material.
Author Statement
Research funding: The research leading to these results has received funding from the Ministry of Science and Higher Education from the budget for science for the years 2016–2020 in the project entitled “Diamentowy Grant” (grant number: DI2015 019045), Funder Id: 10.13039/501100004569.
Conflict of interest: The authors have no conflict of interest.
Informed consent: Informed consent is not applicable.
Ethical approval: The conducted research is not related to either human or animals use.
References
[1] Binnaz Hazar Yoruç A, Cem Şener B. Biomaterials. In: Kara S, editor. A Roadmap of Biomedical Engineers and Milestones. Rijeka: InTech; 2012.10.5772/48057Search in Google Scholar
[2] dos Santos V, Brandalise RN, Savaris M. Engineering of Biomaterials. Cham: Springer International Publishing; 2017.10.1007/978-3-319-58607-6Search in Google Scholar
[3] Jeffrey OH. An Introduction to Biomaterials. Boca Raton, FL: CRC Press; 2011.Search in Google Scholar
[4] Klobes P, Meyer K, Munro RG. Porosity and specifics surface area measurements for solid materials. Gaithersburg: National Institute of Standards and Technology; 2006.Search in Google Scholar
[5] Novaes AB, Souza SLS, Barros RRM, Pereira KKY, Iezzi G, Piattelli A. Influence of implant surfaces on osseointegration. Braz Dent J 2010;21:471–81.10.1590/S0103-64402010000600001Search in Google Scholar
[6] Nowacki J, Dobrzański LA, Gustavo F. Intramedullary implants in osteosynthesis of long bones. OA Lib J 2012;11:56–63.Search in Google Scholar
[7] Rahman S, Ormsby R, Santos A, Atkins GJ, Findlay DM, Losic D. Nanoengineered drug-releasing aluminium wire implants: comparative investigation of nanopore geometry, drug release and osteoblast cell adhesion. RSC Adv 2015;5:75004–14.10.1039/C5RA10418ASearch in Google Scholar
[8] Salerno M, Caneva-Soumetz F, Pastorino L, Patra N, Diaspro A, Ruggiero C. Adhesion and proliferation of osteoblast-like cells on anodic porous alumina substrates with different morphology. IEEE T Nanobiosci 2013;12:106–11.10.1109/TNB.2013.2257835Search in Google Scholar PubMed
[9] Gultepe E, Nagesha D, Sridhar S, Amiji M. Nanoporous inorganic membranes or coatings for sustained drug delivery in implantable devices. Adv Drug Deliver Rev 2010;62:305–15.10.1016/j.addr.2009.11.003Search in Google Scholar PubMed
[10] Laskus A, Kolmas J. Modern delivery systems for bone antibiotics based on hydroxyapatite. Biul Wydz Farm WUM 2016;1:1–6.Search in Google Scholar
[11] Niemirowicz K, Car H. Nanocarriers in modern drug delivery systems. Chemist 2012;66:868–81.Search in Google Scholar
[12] Porta-i-Batalla M, Eckstein C, Xifré-Pérez E, Formentín P, Ferré-Borrull J, Marsal LF. Sustained, controlled and stimuli-responsive drug release systems based on nanoporous anodic alumina with layer-by-layer polyelectrolyte. Nanoscale Res Lett 2016;11:1–9.10.1186/s11671-016-1585-4Search in Google Scholar PubMed PubMed Central
[13] Wang Q, Huang J, Lai Y. Smart drug delivery strategies based on porous nanostructure materials. In: Sezer AD, editor. Smart Drug Delivery System. Rijeka: InTech; 2016:63–90.10.5772/61939Search in Google Scholar
[14] Mainsah E, Greenwood JA, Chetwynd DG. Metrology and Properties of Engineering Surfaces. Dordrecht: Springer; 2010.Search in Google Scholar
[15] Wang H, Chu PK. Surface characterization of biomaterials. In: Bandyopadhyay A, Bose S, editors. Characterization of Biomaterials. Waltham, MA: Elsevier; 2013.Search in Google Scholar
[16] Dubrovski PD, Brezočnik M. The usage of genetic methods for prediction of fabric porosity. In: Ventura S, editor. Genetic Programming: New Approaches and Successful Applications. Rijeka: InTech; 2012:171–98.Search in Google Scholar
[17] King D, McGinty S. Assessing the potential of mathematical modelling in designing drug-releasing orthopaedic implants. J Control Release 2016;239:49–61.10.1016/j.jconrel.2016.08.009Search in Google Scholar PubMed
[18] McGinty S, Pontrelli G. Mathematical modelling of variable porosity coatings for dual drug delivery. 5th International Conference on Computational and Mathematical Biomedical Engineering, USA 2017.10.1016/j.medengphy.2017.04.006Search in Google Scholar PubMed
[19] Md Jani AM, Losic D, Voelcker NH. Nanoporous anodic aluminium oxide: advances in surface engineering and emerging applications. Prog Mater Sci 2013;58:636–704.10.1016/j.pmatsci.2013.01.002Search in Google Scholar
[20] Singh M, Das G. Highly ordered anodic porous alumina membrane and its surface modification approaches for biomedical application. J Appl Chem 2014;7:17–34.10.9790/5736-07111734Search in Google Scholar
[21] Toccafondi C, Dante S, Reverberi AP, Salerno M. Biomedical applications of anodic porous alumina. Curr Nanosci 2015;11:572–80.10.2174/1573413711666150415225541Search in Google Scholar
[22] Castillo JD, Puig P. Testing departures from gamma, Rayleigh and truncated normal distributions. Ann Inst Stat Math 1997;49:255–69.10.1023/A:1003158828665Search in Google Scholar
[23] Romm F. Microporous Media: Synthesis, Properties, and Modeling. New York: Marcel Dekker Inc.; 2004.10.1201/NOE0824758080Search in Google Scholar
[24] Petrou M, Petrou C. Image Processing: The Fundamentals. 2nd ed. Chichester, UK: John Wiley and Sons; 2010.10.1002/9781119994398Search in Google Scholar
[25] Jurczyk M, Jakubowicz J. Bionanomaterials. Poznan: Poznan University of Technology Publishing House; 2008.Search in Google Scholar
©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- The peripheral cannulas in extracorporeal life support
- Research articles
- Determination of optimal positive end-expiratory pressure based on respiratory compliance and electrical impedance tomography: a pilot clinical comparative trial
- Simulation of personalised haemodynamics by various mounting positions of a prosthetic valve using computational fluid dynamics
- Recovery of signal loss adopting the residual bootstrap method in fetal heart rate dynamics
- Optimal level and order detection in wavelet decomposition for PCG signal denoising
- Simple gastric motility assessment method with a single-channel electrogastrogram
- Analysis of on-surface and in-air movement in handwriting of subjects with Parkinson’s disease and atypical parkinsonism
- Wavelet-enhanced convolutional neural network: a new idea in a deep learning paradigm
- Digital microscopic evaluation of vertical marginal discrepancies of CAD/CAM fabricated zirconia cores
- Modelling the degree of porosity of the ceramic surface intended for implants
- How Hedstrom files fail during clinical use? A retrieval study based on SEM, optical microscopy and micro-XCT analysis
- A novel measurement strategy to evaluate the human head as a transition medium for inductive ear-to-ear communication
- Short communication
- Force plates may be used for dynamic analyses of endoprostheses explantation procedures
Articles in the same Issue
- Frontmatter
- Review
- The peripheral cannulas in extracorporeal life support
- Research articles
- Determination of optimal positive end-expiratory pressure based on respiratory compliance and electrical impedance tomography: a pilot clinical comparative trial
- Simulation of personalised haemodynamics by various mounting positions of a prosthetic valve using computational fluid dynamics
- Recovery of signal loss adopting the residual bootstrap method in fetal heart rate dynamics
- Optimal level and order detection in wavelet decomposition for PCG signal denoising
- Simple gastric motility assessment method with a single-channel electrogastrogram
- Analysis of on-surface and in-air movement in handwriting of subjects with Parkinson’s disease and atypical parkinsonism
- Wavelet-enhanced convolutional neural network: a new idea in a deep learning paradigm
- Digital microscopic evaluation of vertical marginal discrepancies of CAD/CAM fabricated zirconia cores
- Modelling the degree of porosity of the ceramic surface intended for implants
- How Hedstrom files fail during clinical use? A retrieval study based on SEM, optical microscopy and micro-XCT analysis
- A novel measurement strategy to evaluate the human head as a transition medium for inductive ear-to-ear communication
- Short communication
- Force plates may be used for dynamic analyses of endoprostheses explantation procedures