Abstract
Two major problems with magnesium (Mg) alloy biomaterials are the poor corrosion resistance and infection associated with implantation. In this study, a novel calcium phosphate (CaP)/tetracycline (TC) composite coating for Mg implants that can both improve the corrosion resistance of Mg and release a drug in a durable way is reported. Scanning electron microscope (SEM) images showed that TC additives make the CaP coating more compact and uniform. Electrochemical tests indicated CaP/TC coatings can provide excellent corrosion protection for Mg alloy substrates. Besides, TC additives can also provide effective prevention of bone infection and inflammation due to its broad-spectrum antibacterial properties. The one-step hydrothermal process reported here greatly simplified the multi-step fabrication of smart coatings reported previously.
Research funding: This work was supported by the Fundamental Research Funds for the Central Universities (XDJK2014C011).
References
[1] Gomes PS, Santos JD, Fernandes MH. Cell-induced response by tetracyclines on human bone marrow colonized hydroxyapatite and Bonelike(R). Acta Biomater 2008; 4: 630–637.10.1016/j.actbio.2007.12.006Search in Google Scholar
[2] Klein C, Patka P, Wolke J, Groot K. Plasma-sprayed coatings of tetracalciumphosphate, hydroxyl-apatite, and α-TCP on titanium alloy: An interface study. J Biomed Mater Res 1991; 25: 53–65.10.1002/jbm.820250105Search in Google Scholar
[3] Kraus T, Fischerauer SF, Hanzi AC, Uggowitzer PJ, Loffler JF, Weinberg AM. Magnesium alloys for temporary implants in osteosynthesis: In vivo studies of their degradation and interaction with bone. Acta Biomater 2012; 8: 1230–1238.10.1016/j.actbio.2011.11.008Search in Google Scholar
[4] Niinomi M. Recent metallic materials for biomedical applications. Metal Mater Trans A – Phys Metal Mater Sci 2002; 33: 477–486.10.1007/s11661-002-0109-2Search in Google Scholar
[5] Pataro AL, Oliveira MF, Teixeira KIR, Turchetti-Maia MM, Lopes MTP. Polymer: bioceramic composites optimization by tetracycline addition. Int J Pharm 2007; 336: 75–81.10.1016/j.ijpharm.2006.11.038Search in Google Scholar
[6] Song YW, Shan DY, Han EH. Electrodeposition of hydroxyapatite coating on AZ91D magnesium alloy for biomaterial applications. Mater Lett 2008; 62: 3276–3279.10.1016/j.matlet.2008.02.048Search in Google Scholar
[7] Song Y, Zhang SX, Li JN, Zhao CL, Zhang XN. Electrodeposition of Ca-P coatings on biodegradable Mg alloy: in vitro biomineralization behavior. Acta Biomater 2010; 6: 1736–1742.10.1016/j.actbio.2009.12.020Search in Google Scholar
[8] Vandekerckhove BN, Quirynen M, Vansteenberghe D. The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis. J Periodontol 1997; 68: 353–361.10.1902/jop.1997.68.4.353Search in Google Scholar
[9] Wei G, Ma PX. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 2004; 25: 4749–4757.10.1016/j.biomaterials.2003.12.005Search in Google Scholar
[10] Wen CE, Mabuchi M, Yamada Y, Shimojima K, Chino Y, Asahina T. Processing of biocompatible porous Ti and Mg. Scr Mater 2001; 45: 1147–1153.10.1016/S1359-6462(01)01132-0Search in Google Scholar
[11] Xi ZX, Tan C, Xu L, Yang N, Li Q. Preparation of novel functional Mg/O/PCL/ZnO composite biomaterials and their corrosion resistance. Appl Surf Sci 2015; 351: 410–415.10.1016/j.apsusc.2015.05.163Search in Google Scholar
[12] Xin YC, Huo KF, Tao H, Tang GY, Chu PK. Influence of aggressive ions on the degradation behavior of biomedical magnesium alloy in physiological environment. Acta Biomater 2008; 4: 2008–2015.10.1016/j.actbio.2008.05.014Search in Google Scholar PubMed
[13] Zong Y, Yuan GY, Zhang XB, Mao L, Niu JL, Ding WJ. Comparison of biodegradable behaviors of AZ31 and Mg-Nd-Zn-Zr alloys in Hank’s physiological solutions. Mater Sci Eng: B 2012; 177: 395–401.10.1016/j.mseb.2011.09.042Search in Google Scholar
©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Efficiency test of current carotid embolic protection devices
- Influence of sizes of abutments and fixation screws on dental implant system: a non-linear finite element analysis
- Biomechanical evaluation of novel ultrasound-activated bioresorbable pins for the treatment of osteochondral fractures compared to established methods
- Fabrication of multifunctional CaP-TC composite coatings and the corrosion protection they provide for magnesium alloys
- An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system
- The influence of implant body and thread design of mini dental implants on the loading of surrounding bone: a finite element analysis
- RapidNAM: generative manufacturing approach of nasoalveolar molding devices for presurgical cleft lip and palate treatment
- Enamel shear bond strength of different primers combined with an orthodontic adhesive paste
- Biomechanical analysis of stiffness and fracture displacement after using PMMA-augmented sacroiliac screw fixation for sacrum fractures
- Regular research articles
- An investigation of the effects of suture patterns on mechanical strength of intestinal anastomosis: an experimental study
- Relationship between linear velocity and tangential push force while turning to change the direction of the manual wheelchair
- Analysis of voluntary opening Ottobock Hook and Hosmer Hook for upper limb prosthetics: a preliminary study
Articles in the same Issue
- Frontmatter
- Efficiency test of current carotid embolic protection devices
- Influence of sizes of abutments and fixation screws on dental implant system: a non-linear finite element analysis
- Biomechanical evaluation of novel ultrasound-activated bioresorbable pins for the treatment of osteochondral fractures compared to established methods
- Fabrication of multifunctional CaP-TC composite coatings and the corrosion protection they provide for magnesium alloys
- An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system
- The influence of implant body and thread design of mini dental implants on the loading of surrounding bone: a finite element analysis
- RapidNAM: generative manufacturing approach of nasoalveolar molding devices for presurgical cleft lip and palate treatment
- Enamel shear bond strength of different primers combined with an orthodontic adhesive paste
- Biomechanical analysis of stiffness and fracture displacement after using PMMA-augmented sacroiliac screw fixation for sacrum fractures
- Regular research articles
- An investigation of the effects of suture patterns on mechanical strength of intestinal anastomosis: an experimental study
- Relationship between linear velocity and tangential push force while turning to change the direction of the manual wheelchair
- Analysis of voluntary opening Ottobock Hook and Hosmer Hook for upper limb prosthetics: a preliminary study