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Extended arrays for nonlinear susceptibility magnitude imaging

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Published/Copyright: June 27, 2015
Biomedical Engineering / Biomedizinische Technik
From the journal Biomedical Engineering / Biomedizinische Technik Volume 60 Issue 5

Abstract

This study implements nonlinear susceptibility magnitude imaging (SMI) with multifrequency intermodulation and phase encoding. An imaging grid was constructed of cylindrical wells of 3.5-mm diameter and 4.2-mm height on a hexagonal two-dimensional 61-voxel pattern with 5-mm spacing. Patterns of sample wells were filled with 40-μl volumes of Fe3O4 starch-coated magnetic nanoparticles (mNPs) with a hydrodynamic diameter of 100 nm and a concentration of 25 mg/ml. The imaging hardware was configured with three excitation coils and three detection coils in anticipation that a larger imaging system will have arrays of excitation and detection coils. Hexagonal and bar patterns of mNP were successfully imaged (R2>0.9) at several orientations. This SMI demonstration extends our prior work to feature a larger coil array, enlarged field-of-view, effective phase encoding scheme, reduced mNP sample size, and more complex imaging patterns to test the feasibility of extending the method beyond the pilot scale. The results presented in this study show that nonlinear SMI holds promise for further development into a practical imaging system for medical applications.

Keywords: magnetic nanoparticles; magnetic susceptibility; nonlinear; tomographic imaging
Corresponding author: Solomon G. Diamond, Thayer School of Engineering at Dartmouth, 14 Engineering Drive, Hanover, NH 03755, USA, Phone: +1-603-646-1311, Fax: +1-603-646-3856, E-mail:

Acknowledgments

This work was supported, in part, by the National Institutes of Health grants 1R21EB016241-01A1, U54-CA151662, and 5-R24-HD065703. The authors gratefully acknowledge the assistance of Josh Page and Kelly Leonard.

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Received: 2015-3-8
Accepted: 2015-6-1
Published Online: 2015-6-27
Published in Print: 2015-10-1

©2015 by De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Magnetic nanoparticles for biomedical applications
  4. Special issue articles
  5. Biomedical applications of high gradient magnetic separation: progress towards therapeutic haeomofiltration
  6. Magnetic nanoparticles adapted for specific biomedical applications
  7. Degradation of magnetic nanoparticles mimicking lysosomal conditions followed by AC susceptibility
  8. Magnetorelaxometry procedures for quantitative imaging and characterization of magnetic nanoparticles in biomedical applications
  9. Magnetic relaxometry as applied to sensitive cancer detection and localization
  10. Extended arrays for nonlinear susceptibility magnitude imaging
  11. Magnetic nanoparticles for magnetic drug targeting
  12. Fluid mechanics aspects of magnetic drug targeting
  13. The possibility of using magnetic nanoparticles to increase the therapeutic efficiency of Herceptin antibody
  14. Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia
  15. Means to increase the therapeutic efficiency of magnetic heating of tumors
https://doi.org/10.1515/bmt-2015-0048
Keywords for this article
magnetic nanoparticles; magnetic susceptibility; nonlinear; tomographic imaging

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Magnetic nanoparticles for biomedical applications
  4. Special issue articles
  5. Biomedical applications of high gradient magnetic separation: progress towards therapeutic haeomofiltration
  6. Magnetic nanoparticles adapted for specific biomedical applications
  7. Degradation of magnetic nanoparticles mimicking lysosomal conditions followed by AC susceptibility
  8. Magnetorelaxometry procedures for quantitative imaging and characterization of magnetic nanoparticles in biomedical applications
  9. Magnetic relaxometry as applied to sensitive cancer detection and localization
  10. Extended arrays for nonlinear susceptibility magnitude imaging
  11. Magnetic nanoparticles for magnetic drug targeting
  12. Fluid mechanics aspects of magnetic drug targeting
  13. The possibility of using magnetic nanoparticles to increase the therapeutic efficiency of Herceptin antibody
  14. Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia
  15. Means to increase the therapeutic efficiency of magnetic heating of tumors
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