Abstract
Experiments and numerical simulations using a flow phantom for magnetic drug targeting have been undertaken. The flow phantom is a half y-branched tube configuration where the main tube represents an artery from which a tumour-supplying artery, which is simulated by the side branch of the flow phantom, branches off. In the experiments a quantification of the amount of magnetic particles targeted towards the branch by a magnetic field applied via a permanent magnet is achieved by impedance measurement using sensor coils. Measuring the targeting efficiency, i.e. the relative amount of particles targeted to the side branch, for different field configurations one obtains targeting maps which combine the targeting efficiency with the magnetic force densities in characteristic points in the flow phantom. It could be shown that targeting efficiency depends strongly on the magnetic field configuration. A corresponding numerical model has been set up, which allows the simulation of targeting efficiency for variable field configuration. With this simulation good agreement of targeting efficiency with experimental data has been found. Thus, the basis has been laid for future calculations of optimal field configurations in clinical applications of magnetic drug targeting. Moreover, the numerical model allows the variation of additional parameters of the drug targeting process and thus an estimation of the influence, e.g. of the fluid properties on the targeting efficiency. Corresponding calculations have shown that the non-Newtonian behaviour of the fluid will significantly influence the targeting process, an aspect which has to be taken into account, especially recalling the fact that the viscosity of magnetic suspensions depends strongly on the magnetic field strength and the mechanical load.
Acknowledgments
Particular gratitude goes to J. Linke and H. Rahn for helpful discussions and careful proof reading of the original manuscript. Financial support by the Deutsche Forschungsgemeinschaft under grant No. OD18/18 is gratefully acknowledged.
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©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorial
- Magnetic nanoparticles for biomedical applications
- Special issue articles
- Biomedical applications of high gradient magnetic separation: progress towards therapeutic haeomofiltration
- Magnetic nanoparticles adapted for specific biomedical applications
- Degradation of magnetic nanoparticles mimicking lysosomal conditions followed by AC susceptibility
- Magnetorelaxometry procedures for quantitative imaging and characterization of magnetic nanoparticles in biomedical applications
- Magnetic relaxometry as applied to sensitive cancer detection and localization
- Extended arrays for nonlinear susceptibility magnitude imaging
- Magnetic nanoparticles for magnetic drug targeting
- Fluid mechanics aspects of magnetic drug targeting
- The possibility of using magnetic nanoparticles to increase the therapeutic efficiency of Herceptin antibody
- Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia
- Means to increase the therapeutic efficiency of magnetic heating of tumors
Articles in the same Issue
- Frontmatter
- Editorial
- Magnetic nanoparticles for biomedical applications
- Special issue articles
- Biomedical applications of high gradient magnetic separation: progress towards therapeutic haeomofiltration
- Magnetic nanoparticles adapted for specific biomedical applications
- Degradation of magnetic nanoparticles mimicking lysosomal conditions followed by AC susceptibility
- Magnetorelaxometry procedures for quantitative imaging and characterization of magnetic nanoparticles in biomedical applications
- Magnetic relaxometry as applied to sensitive cancer detection and localization
- Extended arrays for nonlinear susceptibility magnitude imaging
- Magnetic nanoparticles for magnetic drug targeting
- Fluid mechanics aspects of magnetic drug targeting
- The possibility of using magnetic nanoparticles to increase the therapeutic efficiency of Herceptin antibody
- Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia
- Means to increase the therapeutic efficiency of magnetic heating of tumors