Startseite Neonatal screening for congenital hypothyroidism in Hessen, Germany: efficiency of the screening program and school achievement of 129 children at an age of 8–12 years
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Neonatal screening for congenital hypothyroidism in Hessen, Germany: efficiency of the screening program and school achievement of 129 children at an age of 8–12 years

  • Stefan Höpfner , Bernhard Höpfner und Ernst W. Rauterberg
Veröffentlicht/Copyright: 1. Dezember 2005
Journal of Perinatal Medicine
Aus der Zeitschrift Band 33 Heft 6

Abstract

Status and school achievement of 129 children born in Hessen between 1988 and 1992 and notified by a repeatedly elevated concentration of TSH in neonatal screening were evaluated. Interviews of mothers, teachers and pediatricians were used to score the developmentand educational achievements, respectively. A total of 298,175 newborns were screened and the incidenceof permanent congenital hypothyroidism (PCH) was 1: 3,313 (n=90). The female/male ratio was 1.37:1.

In the 69 PCH cases with complete data, athyreosis (52%), hypoplasia (32%), dyshormogenesis (9%) and ectopia (7%) were identified as etiologies. The mean age at start of therapy decreases from day 15 in 1988 to day 9 in 1992; however, 27% of PCH children showed reduced psychomotor development as scored by their pediatrician and 11% attended a special school for educationally subnormal children. Approximately 25% of the children had lower educational achievements irrespective of the school type. Our finding of a relatively high percentage of PCH children with subnormal development points to a failure in disease management. A follow-up program including repeated serum TSH monitoring and yearly examinations by pediatric endocrinologists and supervision by the regional screening center is necessary to ensure the long-term efficacy of neonatal screening for congenital hypothyroidism.

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Corresponding author: Prof. Dr. med. Ernst W. Rauterberg Screening-Zentrum Hessenan der Universitätskinderklinik Giessen Feulgenstr 12 35392 Giessen Germany Tel.: +49/641/99-43681 Fax +49/641/99-43699

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Published Online: 2005-12-01
Published in Print: 2005-12-01

©2005 by Walter de Gruyter Berlin New York

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