Isolated echogenic intracardiac foci in patients with low-risk triple screen results: assessing the risk of Trisomy 21
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Nikki Koklanaris
Abstract
Objective: While an echogenic intracardiac focus (EIF) is associated with an increased risk of trisomy 21 (T21), the magnitude of that risk remains controversial, particularly in the setting of a low-risk triple screen (TS). The objective of this study is to define the risk of T21 in patients with a low-risk TS and an isolated EIF.
Study design: A retrospective analysis was performed on patients presenting prior to 22 6/7 weeks of gestation. Patients met criteria for inclusion if an EIF was noted, a TS had been drawn, the anatomic survey was complete and was determined to be normal, and karyotyping or delivery occurred at Bellevue Hospital. A high-risk TS was defined as a risk of <1:500, assuming a 2-fold increased risk in the setting of an isolated EIF. A low-risk TS was defined as a risk of >1:500. Statistical analysis was performed using chi-square, with p values of <0.05 considered significant.
Results: 7,318 anatomic surveys were performed. An EIF was identified in 584 patients (7.98%), of which 391 met the criteria for inclusion. Of the 391, 51% were Asian and 38% were Hispanic; 348 had a low-risk TS and 43 had a high-risk TS. Patients with an EIF and a low-risk TS had a significantly lower risk of having a T21 pregnancy compared to those with a high-risk TS and an EIF (0 vs. 2.3%; p=0.004).
Conclusion: An isolated EIF with a low risk TS is not associated with an increased risk of T21.
References
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©2005 by Walter de Gruyter Berlin New York
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- Congress Calendar
- Nomogram of the fetal gastric size development in normal pregnancy
Articles in the same Issue
- Acknowledgement
- Index Volume 33 (2005)
- The role of Fas mediated apoptosis in preeclampsia
- New data about embryonic and fetal neurodevelopment and behavior obtained by 3D and 4D sonography
- A clinical evaluation of controlled-release dinoprostone for cervical ripening – a review of current evidence in hospital and outpatient settings
- The evidence linking maternal nutrition and prematurity
- Hydroxyprogesterone caproate and progesterone increase tumor necrosis factor-alpha production in lipopolysaccharide stimulated whole blood from non-pregnant women
- Routine cervical dilatation during elective cesarean section and its influence on maternal morbidity: a randomized controlled study
- Transient hypothyroxinemia of prematurity and histological chorioamnionitis
- Perinatal outcomes and the use of oral hypoglycemic agents
- Are amniotic fluid C-reactive protein and glucose levels, and white blood cell counts at the time of genetic amniocentesis related with preterm delivery?
- Combined sonographic and endoscopic umbilical cord occlusion in twin and triplet gestations
- Regional difference of endothelium-dependent contractility in human umbilical artery
- Isolated echogenic intracardiac foci in patients with low-risk triple screen results: assessing the risk of Trisomy 21
- Neonatal screening for congenital hypothyroidism in Hessen, Germany: efficiency of the screening program and school achievement of 129 children at an age of 8–12 years
- Utility of a Doppler-derived index combining systolic and diastolic performance (Tei index) for detecting hypoxic cardiac damage in newborns
- Breast-feeding in women with hypertensive disorders in pregnancy
- Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin
- Failure of conservative management of placenta previa-percreta
- Congress Calendar
- Nomogram of the fetal gastric size development in normal pregnancy
