Neonatal screening for congenital hypothyroidism in Hessen, Germany: efficiency of the screening program and school achievement of 129 children at an age of 8–12 years
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Stefan Höpfner
Abstract
Status and school achievement of 129 children born in Hessen between 1988 and 1992 and notified by a repeatedly elevated concentration of TSH in neonatal screening were evaluated. Interviews of mothers, teachers and pediatricians were used to score the developmentand educational achievements, respectively. A total of 298,175 newborns were screened and the incidenceof permanent congenital hypothyroidism (PCH) was 1: 3,313 (n=90). The female/male ratio was 1.37:1.
In the 69 PCH cases with complete data, athyreosis (52%), hypoplasia (32%), dyshormogenesis (9%) and ectopia (7%) were identified as etiologies. The mean age at start of therapy decreases from day 15 in 1988 to day 9 in 1992; however, 27% of PCH children showed reduced psychomotor development as scored by their pediatrician and 11% attended a special school for educationally subnormal children. Approximately 25% of the children had lower educational achievements irrespective of the school type. Our finding of a relatively high percentage of PCH children with subnormal development points to a failure in disease management. A follow-up program including repeated serum TSH monitoring and yearly examinations by pediatric endocrinologists and supervision by the regional screening center is necessary to ensure the long-term efficacy of neonatal screening for congenital hypothyroidism.
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©2005 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- Acknowledgement
- Index Volume 33 (2005)
- The role of Fas mediated apoptosis in preeclampsia
- New data about embryonic and fetal neurodevelopment and behavior obtained by 3D and 4D sonography
- A clinical evaluation of controlled-release dinoprostone for cervical ripening – a review of current evidence in hospital and outpatient settings
- The evidence linking maternal nutrition and prematurity
- Hydroxyprogesterone caproate and progesterone increase tumor necrosis factor-alpha production in lipopolysaccharide stimulated whole blood from non-pregnant women
- Routine cervical dilatation during elective cesarean section and its influence on maternal morbidity: a randomized controlled study
- Transient hypothyroxinemia of prematurity and histological chorioamnionitis
- Perinatal outcomes and the use of oral hypoglycemic agents
- Are amniotic fluid C-reactive protein and glucose levels, and white blood cell counts at the time of genetic amniocentesis related with preterm delivery?
- Combined sonographic and endoscopic umbilical cord occlusion in twin and triplet gestations
- Regional difference of endothelium-dependent contractility in human umbilical artery
- Isolated echogenic intracardiac foci in patients with low-risk triple screen results: assessing the risk of Trisomy 21
- Neonatal screening for congenital hypothyroidism in Hessen, Germany: efficiency of the screening program and school achievement of 129 children at an age of 8–12 years
- Utility of a Doppler-derived index combining systolic and diastolic performance (Tei index) for detecting hypoxic cardiac damage in newborns
- Breast-feeding in women with hypertensive disorders in pregnancy
- Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin
- Failure of conservative management of placenta previa-percreta
- Congress Calendar
- Nomogram of the fetal gastric size development in normal pregnancy
Artikel in diesem Heft
- Acknowledgement
- Index Volume 33 (2005)
- The role of Fas mediated apoptosis in preeclampsia
- New data about embryonic and fetal neurodevelopment and behavior obtained by 3D and 4D sonography
- A clinical evaluation of controlled-release dinoprostone for cervical ripening – a review of current evidence in hospital and outpatient settings
- The evidence linking maternal nutrition and prematurity
- Hydroxyprogesterone caproate and progesterone increase tumor necrosis factor-alpha production in lipopolysaccharide stimulated whole blood from non-pregnant women
- Routine cervical dilatation during elective cesarean section and its influence on maternal morbidity: a randomized controlled study
- Transient hypothyroxinemia of prematurity and histological chorioamnionitis
- Perinatal outcomes and the use of oral hypoglycemic agents
- Are amniotic fluid C-reactive protein and glucose levels, and white blood cell counts at the time of genetic amniocentesis related with preterm delivery?
- Combined sonographic and endoscopic umbilical cord occlusion in twin and triplet gestations
- Regional difference of endothelium-dependent contractility in human umbilical artery
- Isolated echogenic intracardiac foci in patients with low-risk triple screen results: assessing the risk of Trisomy 21
- Neonatal screening for congenital hypothyroidism in Hessen, Germany: efficiency of the screening program and school achievement of 129 children at an age of 8–12 years
- Utility of a Doppler-derived index combining systolic and diastolic performance (Tei index) for detecting hypoxic cardiac damage in newborns
- Breast-feeding in women with hypertensive disorders in pregnancy
- Intrauterine therapy for parvovirus B19 infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin
- Failure of conservative management of placenta previa-percreta
- Congress Calendar
- Nomogram of the fetal gastric size development in normal pregnancy