Startseite Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep

  • Toshiaki Okawa , Shinya Honda , Minoru Sanpei , Tomohiko Ishida , Keiya Fujimori und Akira Sato
Veröffentlicht/Copyright: 4. November 2004
Journal of Perinatal Medicine
Aus der Zeitschrift Band 32 Heft 6

Abstract

Aims: To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF (PGF) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF production in near term fetal sheep.

Methods: Hemodynamic parameters were measured during infusion of big ET-1 into the carotid vein in chronically catheterized fetal sheep on day 125 of gestation. Fetal arterial blood samples were obtained for ET-1, PGF) and nitrate/nitrite (NOx) measurements.

Results: ET-1, NOx and PGF plasma concentrations were all significantly higher in fetal compared with the maternal plasma. Big ET-1 significantly decreased fetal systolic and diastolic blood pressure and significantly increased fetal heart rate. Big ET-1 stimulated plasma PGF), but not NOx, concentration.

Conclusions: Circulatory regulating factors in the fetus were up-regulated. The effects of ET-1 on fetal hemodynamic respnse may be mediated via prostacyclin, but not via the NO pathway.

:

Corresponding author: Toshiaki Okawa, MD, PhD, Department of Obstetrics & Gynecology, Fukushima Medical University School of Medicine, Hikarigaoka 1, 960-1295 Fukushima/Japan. Tel.: +81-24-547-1290, Fax: +81-24-548-3878, E-mail:

References

1 Adamson SL, KJ Whiteley, BL Langille: Endothelin-1 constricts fetoplacental microcirculation and decreases fetal O2 consumption in sheep. Am J Physiol270 (1996) H1610.1152/ajpheart.1996.270.1.H16Suche in Google Scholar

2 Barden AE, CE Herbison, LJ Beilin, CA Michael, BN Walters, FM Van Bockxmeer: Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy. J Hypertens19 (2001) 1775Suche in Google Scholar

3 Bogaert GA, BA Kogan, RA Mevorach, J Wong, GR Gluckman, JR Fineman, MA Heymann: Exogenous endothelin-1 causes renal vasodilation in the fetal lamb. J Urol156 (1996) 847Suche in Google Scholar

4 Chatfield BA, IF McMurtry, SL Hall, SH Abman: Hemodynamic effects of endothelin-1 on ovine fetal pulmonary circulation. Am J Physiol261 (1991) R18210.1152/ajpregu.1991.261.1.R182Suche in Google Scholar

5 Cheung CY: Regulation of atrial natriuretic factor release by endothelin in ovine fetuses. Am J Physiol267 (1004) R38010.1152/ajpregu.1994.267.2.R380Suche in Google Scholar

6 Curtis TM, CN Scholfield: Evidence for two endothelin Et(A) receptor subtypes in rabbit arteriolar smooth muscle. Br J Pharmacol134 (2001) 1787Suche in Google Scholar

7 Docherty CC, J Kalmar-Nagy, M Engelen, PW Nathanielsz: Development of fetal vascular responses to endothelin-1 and acetylcholine in the sheep. Am J Physiol Regul Integr Comp Physiol280 (2001) R55410.1152/ajpregu.2001.280.2.R554Suche in Google Scholar

8 Filep JG, F Herman, B Battistini, PE Chabrier, P Braquet, P Sirois: Antiaggregatory and hypotensive effects of endothelin-1 in beagle dogs: role for prostacyclin. J Cardiovasc Pharmacol17Suppl 7 (1991) S21610.1097/00005344-199100177-00062Suche in Google Scholar

9 Garfield RE, H Maul, L Shi, W Maner, C Fittkow, G Olsen, GR Saade: Methods and devices for the management of term and preterm labor Ann N Y Acad Sci943 (2001) 203Suche in Google Scholar

10 Gomez-Alamillo C, LA Juncos, A Cases, JA Haas, JC Romero: Interactions between vasoconstrictors and vasodilators in regulating hemodynamics of distinct vascular beds. Hypertension42 (2003) 831Suche in Google Scholar

11 Granger JP, BT Alexander, WA Bennett, RA Khalil: Pathophysiology of pregnancy-induced hypertension. Am J Hypertens14 (2001) 178SSuche in Google Scholar

12 Green LR, HH McGarrigle, L Bennet, MA Hanson: The role of endothelin-A receptors in cardiovascular responses to acute hypoxaemia in the late gestation sheep fetus. J Physiol15;509 (1998) 297Suche in Google Scholar

13 Hashiguchi K, K Takagi, M Nakabayashi, Y Takeda, S Sakamoto, M Naruse, K Naruse, H Demura: Relationship between fetal hypoxia and endothelin-1 in fetal circulation. J Cardiovasc Pharmacol17Suppl 7 (1991) S50910.1097/00005344-199100177-00145Suche in Google Scholar

14 Ivy DD, JP Kinsella, SH Abman: Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest93 (1994) 2141Suche in Google Scholar

15 Jones OW 3rd, SH Abman: Systemic and pulmonary hemodynamic effects of big endothelin-1 and phosphoramidon in the ovine fetus Am J Physiol266 (1994) R92610.1152/ajpregu.1994.266.3.R929Suche in Google Scholar

16 Levin ER: Endothelins. N Engl J Med333 (1995) 35610.1056/NEJM199508103330607Suche in Google Scholar

17 Liu HS, TY Chu, MH Yu, YK Chang, CS Ko, CF Chao: Thromboxane and prostacyclin in maternal and fetal circulation in pre-eclampsia. Int J Gynaecol Obstet63 (1998) 1Suche in Google Scholar

18 Matz R, B Van Overloop, AM Dieye, F Pernot, A Gairard: Hypotensive effect of endothelin-1 in a rat model of preeclampsia. Arch Mal Coeur Vaiss91 (1998) 1025 (in French)Suche in Google Scholar

19 Nisell H, A Hemsen, NO Lunell, K Wolff, MJ Lundberg. Maternal and fetal levels of a novel polypeptide, endothelin: evidence for release during pregnancy and delivery. Gynecol Obstet Invest30 (1990) 129Suche in Google Scholar

20 Okawa T, K Anzai, S Honda, M Sanpei, T Ishida, K Fujimori, A Sato, G Saade, RE Garfield: The role of nitric oxide in the fetal sheep. Am J Obstet Gynecol185 (2001) S23910.1016/S0002-9378(01)80615-3Suche in Google Scholar

21 Opgenorth TJ: Endothelin receptor antagonism. Adv Pharmacol33 (1995) 110.1016/S1054-3589(08)60665-1Suche in Google Scholar

22 Sakurai T, M Yanagisawa, Y Takuwa, H Miyazaki, S Kimura, K Goto, T Masaki: Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature348(6303) (1990) 732Suche in Google Scholar

23 Thaete LG, ER Dewey, MG Neerhof: Endothelin and the regulation of uterine and placental perfusion in hypoxiainduced fetal growth restriction. J Soc Gynecol Invest11 (2004) 16Suche in Google Scholar

24 Vosatka RJ, PM Hassoun, KB Harvey-Wilkes: Dietary L-arginine prevents fetal growth restriction in rats. Am J Obstet Gynecol178 (1998) 242Suche in Google Scholar

25 Weiner CP, LP Thompson: Nitric oxide and pregnancy. Semin Perinatol21 (1997) 367Suche in Google Scholar

26 Yamada J, K Fujimori, T Ishida, M Sanpei, S Honda, A Sato: Plasma endothelin-1 and atrial natriuretic peptide levels during prolonged (24-h) non-acidemic hypoxemia in fetal goats. J Maternal-Fetal Med10 (2001) 409Suche in Google Scholar

27 Yamaguchi M, N Mori: 6-Keto prostaglandin F1 alpha, thromboxane B2 and 13, 14-dihydro-15-keto prostaglandin F levels in maternal and fetal plasma. Prostaglandins Leukot Med15 (1984) 325Suche in Google Scholar

28 Yanagisawa M, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature332 (1998) 411Suche in Google Scholar

29 Yang D, U Lang, SG Greenberg, L Myatt, KE Clark: Elevation of nitrate levels in pregnant ewes and their fetuses. Am J Obstet Gynecol174 (1996) 573Suche in Google Scholar

Published Online: 2004-11-04
Published in Print: 2004-11-04

© Walter de Gruyter

Artikel in diesem Heft

  1. Author Index
  2. Subject Index
  3. Contents
  4. Difficult delivery of the impacted fetal head during cesarean section: intraoperative disengagement dystocia
  5. Breech presenting twin A: is vaginal delivery safe?
  6. Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum
  7. Comparison between HELLP syndrome, chronic hypertension, and superimposed preeclampsia on chronic hypertension without HELLP syndrome
  8. Fetal scalp pH and ST analysis of the fetal ECG as an adjunct to CTG. A multi-center, observational study
  9. Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep
  10. Strategy for management of newborns with cervical teratoma
  11. Predicting neonatal outcomes: birthweight, body mass index or ponderal index?
  12. Markers of platelets activation, CD 62P and soluble P-selectin in healthy term neonates
  13. Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death
  14. Plasma endothelin-1 and clinical manifestations of neonatal sepsis
  15. Noncompaction of the left ventricular myocardium diagnosed in pregnant woman and neonate
  16. Ventricular bigeminy misdiagnosed as fetal bradycardia by cardiotocography – the value of non-invasive fetal electrocardiography
  17. Prolonged fetal bradycardia as the presenting clinical sign in Streptococcus agalactiae chorioamnionitis
  18. Changes of blood pressure and heart rate variability precede a grand mal seizure in a pregnant woman
  19. Myocardial infarction in early pregnancy
  20. The baby and the bathwater – a comment
  21. Reply to the opinion paper “The baby or the bathwater: which one should be discarded?”
Heruntergeladen am 8.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/JPM.2004.149/html?lang=de
Button zum nach oben scrollen