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Second overview of relationships between antenatalpharmacologic magnesium sulfate and neurologic outcomes in children
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R. Mittendorf
Veröffentlicht/Copyright:
1. Juni 2005
Abstract
In the last ten years, the body of scientific knowledge concerning the use of antenatal pharmacologic magnesium sulfate (MgSO4) has become substantially larger. Several randomized controlled trials have provided compelling evidence that MgSO4 is the drug of choice for maternal seizure prophylaxis in toxemia. In contrast, the recent Cochrane Systematic Review, as well as other studies, have shown there is no evidence basis for the use of MgSO4 for tocolysis. Furthermore, when tocolyticstrength doses of MgSO4 are employed, there is an excess risk for total pediatric mortality (Cochrane Systematic Review and our own previous work). It is conceivable, nonetheless, that low doses of MgSO4, when used as prophylaxis in some selected cases of preterm labor, may ultimately be shown to be neuroprotective for a relatively small number of children. Unfortunately, the indiscriminate use of high-dosage MgSO4 for attempted tocolysis in preterm labor is much more likely to cause harm than do good.
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Published Online: 2005-06-01
Published in Print: 2004-05-05
Copyright © 2004 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- Second overview of relationships between antenatalpharmacologic magnesium sulfate and neurologic outcomes in children
- Prevention of toxoplasmosis during pregnancy – an epidemiologic survey over 22 consecutive years
- The impact of multiple pregnancies and malformations on perinatal mortality
- Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor
- Perinatal outcome in women with severe pregnancy complications and multiple thrombophilias
- Reproducibility of the study of placental vascularization by three-dimensional power Doppler
- The prevalence of preterm deliveries in Berlin has not changed over 7 years: the impact of multiple births
- Amniotic fluid and cord plasma erythropoietin levels in pregnancies complicated by preeclampsia, pregnancy-induced hypertension and chronic hypertension
- N-Glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro
- Risk factors for fetal-to-maternal transfusion in Rh D-negative women – results of a prospective study on 942 pregnant women
- Does fetal head position at the term plus 12 scan influence induction, labor and delivery outcome?
- Doppler examinations of fetal and uteroplacental blood flow in AGA and IUGR fetuses before and after maternal physical exercise with the bicycle ergometer
- Maternal serum, amniotic fluid and cord leptin levels at term: their correlations with fetal weight
- Intrauterine smoke exposure: a new risk factor for bronchopulmonary dysplasia?
- Effect of Phenobarbital on free radicals in neonates with hypoxic ischemic encephalopathy – a randomized controlled trial
- Increase in cord blood soluble E-selectin and tracheal aspirate neutrophils at birth and the development of new bronchopulmonary dysplasia
- Biliary atresia due to delayed maturation of the gut hormones system? – Introducing a new treatment modality
Artikel in diesem Heft
- Second overview of relationships between antenatalpharmacologic magnesium sulfate and neurologic outcomes in children
- Prevention of toxoplasmosis during pregnancy – an epidemiologic survey over 22 consecutive years
- The impact of multiple pregnancies and malformations on perinatal mortality
- Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor
- Perinatal outcome in women with severe pregnancy complications and multiple thrombophilias
- Reproducibility of the study of placental vascularization by three-dimensional power Doppler
- The prevalence of preterm deliveries in Berlin has not changed over 7 years: the impact of multiple births
- Amniotic fluid and cord plasma erythropoietin levels in pregnancies complicated by preeclampsia, pregnancy-induced hypertension and chronic hypertension
- N-Glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro
- Risk factors for fetal-to-maternal transfusion in Rh D-negative women – results of a prospective study on 942 pregnant women
- Does fetal head position at the term plus 12 scan influence induction, labor and delivery outcome?
- Doppler examinations of fetal and uteroplacental blood flow in AGA and IUGR fetuses before and after maternal physical exercise with the bicycle ergometer
- Maternal serum, amniotic fluid and cord leptin levels at term: their correlations with fetal weight
- Intrauterine smoke exposure: a new risk factor for bronchopulmonary dysplasia?
- Effect of Phenobarbital on free radicals in neonates with hypoxic ischemic encephalopathy – a randomized controlled trial
- Increase in cord blood soluble E-selectin and tracheal aspirate neutrophils at birth and the development of new bronchopulmonary dysplasia
- Biliary atresia due to delayed maturation of the gut hormones system? – Introducing a new treatment modality
