Amniotic fluid and cord plasma erythropoietin levels in pregnancies complicated by preeclampsia, pregnancy-induced hypertension and chronic hypertension
-
K.A. Teramo
Abstract
Aims: The purpose of the present study was to compare fetal and neonatal outcomes with amniotic fluid erythropoietin (EPO) levels obtained in the antepartum period in pregnancies complicated by preeclampsia, pregnancy-induced hypertension or chronic hypertension.
Methods: Erythropoietin concentrations were measured in amniotic fluid within 2 days before delivery and in cord blood at birth in 75 hypertensive women and in 23 healthy controls delivered by cesarean section before labor contractions. Erythropoietin levels did not influence clinical decisions.
Results: Amniotic fluid erythropoietin levels correlated highly significantly with cord plasma EPO levels and were significantly higher in pregnancies complicated by hypertension than in control pregnancies. Umbilical arterial pH, acid-base and blood gas values at birth were not different from controls. Both cord plasma and amniotic fluid erythropoietin levels correlated with cord blood pH, acidbase and blood gas values at birth in the study group. Newborn infants admitted to the newborn intensive care unit had significantly higher fetal erythropoietin levels and were more acidotic, hypoxemic and hypoglycemic than infants admitted to the normal care nursery.
Conclusions: Our findings suggest that elevated amniotic fluid erythropoietin levels are markers of chronic or subchronic fetal hypoxia and are associated with neonatal morbidity in pregnancies complicated by hypertension.
Copyright (c) 2004 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Second overview of relationships between antenatalpharmacologic magnesium sulfate and neurologic outcomes in children
- Prevention of toxoplasmosis during pregnancy – an epidemiologic survey over 22 consecutive years
- The impact of multiple pregnancies and malformations on perinatal mortality
- Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor
- Perinatal outcome in women with severe pregnancy complications and multiple thrombophilias
- Reproducibility of the study of placental vascularization by three-dimensional power Doppler
- The prevalence of preterm deliveries in Berlin has not changed over 7 years: the impact of multiple births
- Amniotic fluid and cord plasma erythropoietin levels in pregnancies complicated by preeclampsia, pregnancy-induced hypertension and chronic hypertension
- N-Glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro
- Risk factors for fetal-to-maternal transfusion in Rh D-negative women – results of a prospective study on 942 pregnant women
- Does fetal head position at the term plus 12 scan influence induction, labor and delivery outcome?
- Doppler examinations of fetal and uteroplacental blood flow in AGA and IUGR fetuses before and after maternal physical exercise with the bicycle ergometer
- Maternal serum, amniotic fluid and cord leptin levels at term: their correlations with fetal weight
- Intrauterine smoke exposure: a new risk factor for bronchopulmonary dysplasia?
- Effect of Phenobarbital on free radicals in neonates with hypoxic ischemic encephalopathy – a randomized controlled trial
- Increase in cord blood soluble E-selectin and tracheal aspirate neutrophils at birth and the development of new bronchopulmonary dysplasia
- Biliary atresia due to delayed maturation of the gut hormones system? – Introducing a new treatment modality
Articles in the same Issue
- Second overview of relationships between antenatalpharmacologic magnesium sulfate and neurologic outcomes in children
- Prevention of toxoplasmosis during pregnancy – an epidemiologic survey over 22 consecutive years
- The impact of multiple pregnancies and malformations on perinatal mortality
- Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor
- Perinatal outcome in women with severe pregnancy complications and multiple thrombophilias
- Reproducibility of the study of placental vascularization by three-dimensional power Doppler
- The prevalence of preterm deliveries in Berlin has not changed over 7 years: the impact of multiple births
- Amniotic fluid and cord plasma erythropoietin levels in pregnancies complicated by preeclampsia, pregnancy-induced hypertension and chronic hypertension
- N-Glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro
- Risk factors for fetal-to-maternal transfusion in Rh D-negative women – results of a prospective study on 942 pregnant women
- Does fetal head position at the term plus 12 scan influence induction, labor and delivery outcome?
- Doppler examinations of fetal and uteroplacental blood flow in AGA and IUGR fetuses before and after maternal physical exercise with the bicycle ergometer
- Maternal serum, amniotic fluid and cord leptin levels at term: their correlations with fetal weight
- Intrauterine smoke exposure: a new risk factor for bronchopulmonary dysplasia?
- Effect of Phenobarbital on free radicals in neonates with hypoxic ischemic encephalopathy – a randomized controlled trial
- Increase in cord blood soluble E-selectin and tracheal aspirate neutrophils at birth and the development of new bronchopulmonary dysplasia
- Biliary atresia due to delayed maturation of the gut hormones system? – Introducing a new treatment modality
