Intrauterine smoke exposure: a new risk factor for bronchopulmonary dysplasia?
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R. Antonucci
Abstract
Objective: To evaluate the role of intrauterine smoke exposure and other variables on the development of bronchopulmonary dysplasia (BPD) in infants with birth weight <1500 g (VLBW).
Methods: This case-control study investigated 277 VLBW infants (141 cases, 136 controls) admitted at birth to neonatal intensive care unit and survived to discharge. A retrospective telephone interview provided detailed parental information supplementing clinical data. Logistic regression assessed the effects of birth weight <1000 g, gestational age <30 weeks (GA<30), respiratory distress syndrome (RDS), neonatal mechanical ventilation >7 days (MV>7), patent ductus arteriosus (PDA), intrauterine smoke exposure ≥3 months (ISE), and of parental history of asthma on BPD (oxygen dependency at 28 days with characteristic radiographic abnormalities) occurrence.
Results: Including all variables, only GA<30, RDS and MV>7 were significantly associated with BPD. ISE did not contribute significantly to this model (odds ratio wORx 1.94; 95% confidence interval 0.88–4.26). Excluding iatrogenic variable MV>7, GA<30, RDS, PDA and ISE (OR 2.21; 95% confidence interval 1.03–4.76) were significantly associated with BPD. Analyzing GA as a continuous variable, the OR was 0.63 for each additional week.
Conclusions: Prolonged mechanical ventilation, RDS and low gestational age were the major BPD determinants. Intrauterine smoke exposure seems to influence independently BPD development.
Copyright © 2004 by Walter de Gruyter GmbH & Co. KG
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- Second overview of relationships between antenatalpharmacologic magnesium sulfate and neurologic outcomes in children
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- The impact of multiple pregnancies and malformations on perinatal mortality
- Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor
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- Amniotic fluid and cord plasma erythropoietin levels in pregnancies complicated by preeclampsia, pregnancy-induced hypertension and chronic hypertension
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