DNA microarrays detect the expression of apoptosis-related genes in preeclamptic placentas
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Z.-J. Pang
Abstract
Aims: To investigate the expression of apoptosis-related genes in preeclamptic placentas and the possible mechanism of the regulation process. Methods: Complementary DNA microarrays were employed to compare gene expression profiles of five preeclamptic and five normal placentas. Results: Among the 368 genes detected over 35% showed an over 2-fold difference of expression between preeclamptic placentas and normal placentas. Many genes involved in cell cycle or apoptosis were more highly expressed in preeclamptic placentas than in normal placentas. The expression of many immune-activation genes in preeclamptic placentas was also higher than that in normal placentas. Additionally, many cytokine receptor/ kinase genes were also induced in preeclamptic placentas. Conclusions: The change in expression of cell apoptosis related genes in placentas might be involved in the pathogenesis of preeclampsia, while the activation of the immune system might be one cause of this change.
Copyright © 2004 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- Editorial
- The role of ultrasonography in recognizing the cause of fetal cerebral ventriculomegaly
- A kick from within – fetal movement counting and the cancelled progress in antenatal care
- DNA microarrays detect the expression of apoptosis-related genes in preeclamptic placentas
- Indicated labor induction with vaginal prostaglandin E2 increases the risk of cesarean section even in multiparous women with no previous cesarean section
- Cervical immunoglobulin A and altered vaginal flora in pregnant women with threatened preter delivery
- Multiple courses of antenatal corticosteroid therapy in patients with preterm premature rupture of membranes
- Implication of cord blood myeloperoxidase but of soluble p-selectin levels in preterm deliveries
- Fetal and early postnatal magnetic resonance imaging – is there a difference?
- Bone turnover markers and bone strength during the first weeks of life in very low birth weight premature infants
- The ponderal index in triplets: I. Relationship to small for gestational age neonates
- The ponderal index in triplets: II. Gestational age-related patterns of neonatal weights and lengths
- The ponderal index in triplets: III. Association with birth weight discordance
- The ponderal index in triplets: IV. Relationship with maternal height
- Intratracheal albumin reduces interleukin-8 in tracheobronchial aspirates in piglets after meconium aspiration
- The pulmonary paradox in premature infants: in-utero infected lungs do better than those with accelerated maturation
- Congenital syphilis: unique clinical presentation in three preterm newborns
- Twin-to-twin transfusion syndrome complicated by spontaneous mid-trimester uterine rupture
- Persistent pulmonary hypertension in a premature newborn after 16 hours of antenatal indomethacin exposure
- Congress Calendar
- Roster of Perinatal Societies
