Intratracheal albumin reduces interleukin-8 in tracheobronchial aspirates in piglets after meconium aspiration
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P. A. Tølløfsrud
Abstract
Meconium aspiration induces pulmonary inflammation and reduces surfactant function. We hypothesized that albumin mixed with meconium attenuates pulmonary inflammation and improves surfactant function after meconium aspiration. We measured the concentration of free fatty acids (FFA) in the meconium (110 mg dry weight/mL) and added albumin to provide a molar FFA:albumin ratio of 1:1. Newborn piglets, 0-2 day of age, artificially ventilated and exposed to hypoxemia by ventilation with 8% O[2], were randomized to group A receiving meconium (n=12), or group B receiving meconium + albumin (n=12), 3 ml/kg intratracheally. The animals were reoxygenated for 8 h. Reoxygenation was started when mean arterial blood pressure was <20 mm Hg or base excess was <-20 mmol/L. During 8 h of reoxygenation the interleukin-8 concentrations in tracheobronchial aspirates increased 5-fold more in the meconium vs. the meconium + albumin groups (93+-56 vs. 18+-4 pg/mL, p<0.005). There were no differences between the groups for tumor necrosis factor α in tracheobronchial aspirates, recruitment of inflammatory cells in the airspaces or surfactant function in bronchoalveolar lavage fluid. In conclusion, albumin significantly decreased interleukin-8 concentrations in tracheobronchial aspirates after meconium aspiration.
Copyright © 2004 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Editorial
- The role of ultrasonography in recognizing the cause of fetal cerebral ventriculomegaly
- A kick from within – fetal movement counting and the cancelled progress in antenatal care
- DNA microarrays detect the expression of apoptosis-related genes in preeclamptic placentas
- Indicated labor induction with vaginal prostaglandin E2 increases the risk of cesarean section even in multiparous women with no previous cesarean section
- Cervical immunoglobulin A and altered vaginal flora in pregnant women with threatened preter delivery
- Multiple courses of antenatal corticosteroid therapy in patients with preterm premature rupture of membranes
- Implication of cord blood myeloperoxidase but of soluble p-selectin levels in preterm deliveries
- Fetal and early postnatal magnetic resonance imaging – is there a difference?
- Bone turnover markers and bone strength during the first weeks of life in very low birth weight premature infants
- The ponderal index in triplets: I. Relationship to small for gestational age neonates
- The ponderal index in triplets: II. Gestational age-related patterns of neonatal weights and lengths
- The ponderal index in triplets: III. Association with birth weight discordance
- The ponderal index in triplets: IV. Relationship with maternal height
- Intratracheal albumin reduces interleukin-8 in tracheobronchial aspirates in piglets after meconium aspiration
- The pulmonary paradox in premature infants: in-utero infected lungs do better than those with accelerated maturation
- Congenital syphilis: unique clinical presentation in three preterm newborns
- Twin-to-twin transfusion syndrome complicated by spontaneous mid-trimester uterine rupture
- Persistent pulmonary hypertension in a premature newborn after 16 hours of antenatal indomethacin exposure
- Congress Calendar
- Roster of Perinatal Societies
