The impact of intrapartum factors on umbilical cord blood stem cell banking
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U. Aufderhaar
Abstract
Aims: Umbilical cord blood can be used as an alternative source for related and unrelated allogeneic stem cell transplantation. This study was undertaken to determine whether intrapartum factors have an influence on the hematopoietic cell compartment of cord blood.
Methods: Cord blood samples were obtained from 102 normal full-term deliveries for the banking of stem cells. We analyzed the influence of intrapartum factors on the count of CD34+ cells, total nucleated cells, colony forming units and total volume of collection. Fluorescence-activated cell sorting was used to measure CD34+ cell numbers. Statistical analysis was undertaken using Pearson correlation test and multiple regression analysis.
Results: The higher the infants' birthweight the larger was the volume. A lower arterial umbilical pH and a larger blood volume resulted in an increased number of CD34+ cells. A large blood volume, long duration of labor, lower arterial and venous pH were correlated with more nucleated cells. A higher birthweight, larger blood volume and lower arterial pH resulted in an increased number of colony forming units.
Conclusions: Some intrapartum factors have an impact on the characteristics of collected cord blood cells. Stress during delivery may influence the number of hematopoetic cells, through altered cytokine production. This knowledge may facilitate the selection of optimal cord blood samples for unrelated banking and the early discarding of suboptimal cord blood samples thus resulting in the saving of costs related to expensive further processing.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Bioelectrical impedance analysis in the clinical management of preeclamptic women with edema
- Decreasing resistance in the maternal uterine and peripheral arterial system is apparently unrelated to plasma and urinary levels of nitrite/nitrate and cyclic-guanosinmonophosohate during the course of normal pregnancies
- Inducing proliferation of human amnion epithelial and mesenchymal cells for prospective engineering of membrane repair
- Obstetric outcome of excessively overgrown fetuses (≥= 5000 g): a case-control study
- Computerized analysis of fetal heart rate indices during oral glucose tolerance test
- Comparison of perinatal outcome in fetuses with reverse or absent enddiastolic flow in the umbilical artery and/or fetal descending aorta
- Operative fetoscopical management of intrauterine obstructive uropathia by urethral stent
- The impact of intrapartum factors on umbilical cord blood stem cell banking
- Neonatal nucleated red blood cell count and postpartum complications in growth restricted fetuses
- Neonatal outcome of growth discordant twin gestations
- Management of unscarred ruptured uterus
- Lethargy in a newborn: lithium toxicity or lab error?
- Acute ethanol intoxication during pregnancy and consecutive fetal cardiac arrest: a case report
- Acute pancreatitis occurring in the early postpartum period: a case report
- Book Review
- Congress Calendar
