Decreasing resistance in the maternal uterine and peripheral arterial system is apparently unrelated to plasma and urinary levels of nitrite/nitrate and cyclic-guanosinmonophosohate during the course of normal pregnancies
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B. Schiessl
Abstract
Aims: The aim of the presented study was to clarify the relationship between the pulsatility index of the uterine arteries and the maternal cubital artery and peripheral concentrations of the metabolites of nitric oxide (NO) and its second messenger cyclic guanosinmonophophate (cGMP) during the normal course of pregnancy and postpartum.
Methods: 49 uncomplicated pregnancies were investigated every 4–6 weeks until delivery, 29 of them were additionally investigated postpartum. Paralleling each Doppler sonografic investigation maternal blood and urine samples were taken. The measurements of nitrite/nitrate and cGMP were performed with a colorimetric and radio immuno assay.
We demonstrate a significant decrease of the PI of the uterine arteries and of the cubital artery with inverse correlation to advancing gestational age.
Results: The concentrations of nitrite/nitrate and cGMP remain stable during gestation and do not correlate to the PI of the uterine and cubital artery. Postpartum a re-increase in the uterine and peripheral resistance can be shown. The concentrations of urinary cGMP and nitrite/nitrate as well as plasma cGMP remain unchanged, whereas plasma nitrite/nitrate decreases postpartum.
Conclusions: The status of NO biosyntheses in normal pregnancy remains controversial. We hypothesize further systemically acting mediators which contribute to the decreasing vascular resistance.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Bioelectrical impedance analysis in the clinical management of preeclamptic women with edema
- Decreasing resistance in the maternal uterine and peripheral arterial system is apparently unrelated to plasma and urinary levels of nitrite/nitrate and cyclic-guanosinmonophosohate during the course of normal pregnancies
- Inducing proliferation of human amnion epithelial and mesenchymal cells for prospective engineering of membrane repair
- Obstetric outcome of excessively overgrown fetuses (≥= 5000 g): a case-control study
- Computerized analysis of fetal heart rate indices during oral glucose tolerance test
- Comparison of perinatal outcome in fetuses with reverse or absent enddiastolic flow in the umbilical artery and/or fetal descending aorta
- Operative fetoscopical management of intrauterine obstructive uropathia by urethral stent
- The impact of intrapartum factors on umbilical cord blood stem cell banking
- Neonatal nucleated red blood cell count and postpartum complications in growth restricted fetuses
- Neonatal outcome of growth discordant twin gestations
- Management of unscarred ruptured uterus
- Lethargy in a newborn: lithium toxicity or lab error?
- Acute ethanol intoxication during pregnancy and consecutive fetal cardiac arrest: a case report
- Acute pancreatitis occurring in the early postpartum period: a case report
- Book Review
- Congress Calendar
