Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
The role of mean platelet volume in predicting thrombotic events
-
Yucel Colkesen
und
Haldun Muderrisoglu
Veröffentlicht/Copyright:
24. November 2011
Abstract
Studies on platelet function have accelerated and gained popularity since the advent of novel treatment modalities and techniques on atherosclerotic vascular disease, such as antiplatelet drugs and stents. Today it is widely known that platelets exert a fundamental role in inflammation in addition to their long known role in homeostasis and thrombotic events. Interaction with endothelial cells and leukocytes mediates inflammation, contributes to atherogenesis and modulates immune activity. Platelet activation which is a central factor in many arterial disorders may be triggered by multiple pathways. Platelet activation is shown as forming a larger shape, aggregation and releasing various active contents. Mean platelet volume is a marker of platelet size, function and activation. Increased mean platelet volume is shown by active and large platelets that release more thromboxane A2 than smaller ones. The aim of this review is to determine whether early detection of platelet activation via increased mean platelet volume would help to recognize the pro-inflammatory state and administer appropriate and effective treatment properly. An easily detectable marker by using a prompt and functional technique would help our approach to inflammation caused by platelets.
Received: 2011-9-9
Accepted: 2011-11-10
Published Online: 2011-11-24
Published in Print: 2012-04-01
©2012 by Walter de Gruyter Berlin Boston
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- A sensitive quantitative test strip based point-of-care albuminuria screening assay
- Editorials
- Serum biomarkers for the non-invasive diagnosis of liver fibrosis: the importance of being validated
- Primary blood tubes mixing: time for updated recommendations
- Reviews
- 10.1515/cclm-2011-0847
- The hCG assay or pregnancy test
- Mini Reviews
- The role of mean platelet volume in predicting thrombotic events
- The role of red blood cell distribution width in cardiovascular and thrombotic disorders
- Genetics and Molecular Diagnostics
- Comparison of different collection procedures and two methods for DNA isolation from saliva
- Detection of α-globin gene deletion and duplication using quantitative multiplex PCR of short fluorescent fragments
- High-throughput detection, genotyping and quantification of the human papillomavirus using real-time PCR
- General Clinical Chemistry and Laboratory Medicine
- Quantification of human serum insulin concentrations in clinical pharmacokinetic or bioequivalence studies: what defines the “best method”?
- Serum cystatin C is an early biomarker for assessment of renal function in burn patients
- 10.1515/cclm.2011.0849
- Mid-stream vs. first-voided urine collection by using automated analyzers for particle examination in healthy subjects: an Italian multicenter study
- Percentage of hypochromic erythrocytes as a potential marker of iron availability
- Laboratory evaluation of a flow cytometric BCR-ABL immunobead assay
- Validation and Outcome Studies
- Independent validation of the Enhanced Liver Fibrosis (ELF) score in the ANRS HC EP 23 Fibrostar cohort of patients with chronic hepatitis C
- Cancer Diagnostics
- Demasking of epithelial cell adhesion molecule (EpCAM) on circulating epithelial tumor cells by Tween®20 treatment in breast cancer patients
- Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer
- Blood presence of circulating oncofetal fibronectin mRNA, by RT-PCR, does not represent a useful specific marker for the management and follow-up of thyroid cancer patients
- Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers
- Cardiovascular Diseases
- The performance of high sensitivity troponin for the diagnosis of acute myocardial infarction is underestimated
- The prognostic value of N-terminal pro-brain natriuretic peptide in non-ST elevation acute coronary syndromes: a meta-analysis
- Measurement of high-molecular-weight adiponectin is not useful in assessing coronary stenosis
- Letters to the Editor
- Serum concentration of neopterin on admission does not improve the diagnostic performance of highly-sensitive troponin I
- Evaluation of the interference by homogentisic acid and other organic acids on the enzymatic and Jaffé method creatinine assay
- A comparative analysis of the Iris iQ200 with manual microscopy as a diagnostic tool for dysmorphic erythrocytes in urine
- Falsely decreased ionized calcium results due to analytical interference by teriflunomide, the active metabolite of leflunomide (Arava®)
- Is polyethylene glycol precipitation of hyperprolactinaemic samples required when using the Beckman Coulter DxI-800 prolactin assay?
- Congress Abstracts
- ISMD2012: Ninth International Symposium on Molecular Diagnostics
- ArabMedLab Marrakech 2012
- Masthead
- Masthead
Artikel in diesem Heft
- A sensitive quantitative test strip based point-of-care albuminuria screening assay
- Editorials
- Serum biomarkers for the non-invasive diagnosis of liver fibrosis: the importance of being validated
- Primary blood tubes mixing: time for updated recommendations
- Reviews
- 10.1515/cclm-2011-0847
- The hCG assay or pregnancy test
- Mini Reviews
- The role of mean platelet volume in predicting thrombotic events
- The role of red blood cell distribution width in cardiovascular and thrombotic disorders
- Genetics and Molecular Diagnostics
- Comparison of different collection procedures and two methods for DNA isolation from saliva
- Detection of α-globin gene deletion and duplication using quantitative multiplex PCR of short fluorescent fragments
- High-throughput detection, genotyping and quantification of the human papillomavirus using real-time PCR
- General Clinical Chemistry and Laboratory Medicine
- Quantification of human serum insulin concentrations in clinical pharmacokinetic or bioequivalence studies: what defines the “best method”?
- Serum cystatin C is an early biomarker for assessment of renal function in burn patients
- 10.1515/cclm.2011.0849
- Mid-stream vs. first-voided urine collection by using automated analyzers for particle examination in healthy subjects: an Italian multicenter study
- Percentage of hypochromic erythrocytes as a potential marker of iron availability
- Laboratory evaluation of a flow cytometric BCR-ABL immunobead assay
- Validation and Outcome Studies
- Independent validation of the Enhanced Liver Fibrosis (ELF) score in the ANRS HC EP 23 Fibrostar cohort of patients with chronic hepatitis C
- Cancer Diagnostics
- Demasking of epithelial cell adhesion molecule (EpCAM) on circulating epithelial tumor cells by Tween®20 treatment in breast cancer patients
- Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer
- Blood presence of circulating oncofetal fibronectin mRNA, by RT-PCR, does not represent a useful specific marker for the management and follow-up of thyroid cancer patients
- Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers
- Cardiovascular Diseases
- The performance of high sensitivity troponin for the diagnosis of acute myocardial infarction is underestimated
- The prognostic value of N-terminal pro-brain natriuretic peptide in non-ST elevation acute coronary syndromes: a meta-analysis
- Measurement of high-molecular-weight adiponectin is not useful in assessing coronary stenosis
- Letters to the Editor
- Serum concentration of neopterin on admission does not improve the diagnostic performance of highly-sensitive troponin I
- Evaluation of the interference by homogentisic acid and other organic acids on the enzymatic and Jaffé method creatinine assay
- A comparative analysis of the Iris iQ200 with manual microscopy as a diagnostic tool for dysmorphic erythrocytes in urine
- Falsely decreased ionized calcium results due to analytical interference by teriflunomide, the active metabolite of leflunomide (Arava®)
- Is polyethylene glycol precipitation of hyperprolactinaemic samples required when using the Beckman Coulter DxI-800 prolactin assay?
- Congress Abstracts
- ISMD2012: Ninth International Symposium on Molecular Diagnostics
- ArabMedLab Marrakech 2012
- Masthead
- Masthead
