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Measurement of high-molecular-weight adiponectin is not useful in assessing coronary stenosis

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Published/Copyright: December 17, 2011
Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 50 Issue 4

Abstract

Background: In many studies, high-molecular-weight (HMW) adiponectin has been considered the active form of adiponectin. However, whether HMW adiponectin is a good surrogate marker for coronary artery disease still needs to be elucidated.

Methods: We conducted a hospital-based cross-sectional study to examine the relationship between total, HMW or non-HMW adiponectin concentrations and coronary stenosis in 83 male patients and 138 male controls.

Results: Patients with coronary stenosis had significantly lower total adiponectin concentrations compared with controls. Non-HMW adiponectin concentrations in cases were significantly lower than the controls. However, there were no significant differences between cases and controls in HMW adiponectin concentrations. From the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for total and non-HMW adiponectin was significantly larger than that for HMW adiponectin concentrations. Of the three models, that for non-HMW adiponectin showed the largest AUC (total adiponectin 0.74, HMW adiponectin 0.54, and non-HMW adiponectin 0.79).

Conclusions: Despite associations between total adiponectin levels and coronary stenosis, our data go against any apparent association between HMW adiponectin concentrations and coronary stenosis.

Keywords: coronary stenosis; epidemiology; high-molecular-weight adiponectin
Corresponding author: Takuya Imatoh, PhD, Department of Preventive Medicine and Public Health, School of Medicine, Fukuoka University 7-45-1, Nanakuma, Jonan-ku, Fukuoka City, Fukuoka 814-0180, Japan Phone: +81 92 8011011 ext 3305, Fax: +81 92 8638892
Received: 2011-6-1
Accepted: 2011-11-21
Published Online: 2011-12-17
Published in Print: 2012-04-01

©2012 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/cclm.2011.832
Keywords for this article
coronary stenosis; epidemiology; high-molecular-weight adiponectin

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  1. A sensitive quantitative test strip based point-of-care albuminuria screening assay
  2. Editorials
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