The effect of a one-year weight reduction program on serum uric acid in overweight/obese children and adolescents
-
Malgorzata Krzystek-Korpacka
,
Eliza Patryn
Abstract
Background: Hyperuricemia may underlie obesity and related disorders, but the impact of weight reduction and metformin on serum uric acid (sUA) in Caucasian children/adolescents is unknown.
Methods: One hundred and thirteen children/adolescents were enrolled (83 completed) into 1-year weight reduction program (diet+exercise) without or with metformin. Anthropometric and biochemical measurements were conducted at baseline and at the end of follow-up (13±3 months).
Results: sUA decreased in 86% females and 67% males. Significantly more patients substantially (≥10%) reduced their sUA than body mass index (BMI)%. In females, sUA decreased regardless of type of intervention, but more markedly in the metformin group, and ΔsUA correlated positively with ΔBMI%, ΔWHtR (waist-to-height ratio), Δinsulin, ΔHOMA (homeostasis model of assessment), and Δtriglycerides/high density lipoprotein (HDL), but correlated negatively with baseline sUA, HOMA, insulin, and triglycerides/HDL. Of these, metformin treatment, baseline sUA, and ΔBMI% were independent predictors of sUA reduction, explaining 77% of data variability. In males, sUA reduction was significant in the metformin group only, and negatively correlated with ΔWHR (waist-to-hip ratio), ΔWHtR, Δleptin, baseline sUA, and waist circumference. Of these, baseline sUA and ΔBMI% were independent predictors of sUA reduction, explaining 69% of data variability. Except for sUA, females reduced their BMI%, waist circumference, triglycerides, triglycerides/HDL and increased HDL, while males reduced total cholesterol.
Conclusions: A longitudinal weight reduction program encompassing diet/exercise with or without metformin was more efficient in reducing sUA than weight and its effect on sUA and other metabolic parameters differed between genders. Weight loss did not condition sUA reduction, which was strongly dependent on baseline levels. The sUA reducing effects of metformin may contribute to its effects on blood pressure-lowering and endothelial function-improving properties in females.
©2011 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- Editorials
- Laboratory testing and/or monitoring of the new oral anticoagulants/antithrombotics: for and against?
- Circulating macrocomplexes: old wine in new bottles?
- Review
- Laboratory assessment of new anticoagulants
- Minireviews
- Biomarkers in Alzheimer’s disease
- Analytical variability in sport hematology: its importance in an antidoping setting
- The plodding diagnosis of monogenic autoinflammatory diseases in childhood: from the clinical scenery to laboratory investigation
- Opinion Paper
- Collective opinion paper on findings of the 2010 convocation of experts on laboratory quality
- Genetics and Molecular Diagnostics
- Genetic variability of the fructosamine 3-kinase gene in diabetic patients
- Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis
- Performance evaluation of a multiplex assay for future use in biomarker discovery efforts to predict body composition
- Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes
- General Clinical Chemistry and Laboratory Medicine
- Quality Indicators in Laboratory Medicine: from theory to practice
- Implementation of computerized add-on testing for hospitalized patients in a large academic medical center
- Human growth hormone (GH) immunoassay: standardization and clinical implications
- Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology1)
- Trefoil factor family peptides in human saliva and cyclical cervical mucus. Method evaluation and results on healthy individuals
- Steroid binding properties of the 2nd WHO International Standard for sex hormone-binding globulin
- Thyroxin overdose due to rheumatoid factor interferences in thyroid-stimulating hormone assays
- Cancer Diagnostics
- Quantification of HER2 autoantibodies in the amplification phenomenon of HER2 in breast cancer
- Glycosylation of proteins in healthy and neoplastic human salivary glands – a preliminary study
- Infectious Diseases
- Quantification of cerebrospinal fluid lactic acid in the differential diagnosis between HIV chronic meningitis and opportunistic meningitis
- Cardiovascular Diseases
- Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients
- High concentrations of asymmetric dimethylarginine are associated with ST-segment resolution failure after reperfusion for acute myocardial infarction
- An increase in serum uric acid concentrations is associated with an increase in the Framingham risk score in Korean adults
- The effect of a one-year weight reduction program on serum uric acid in overweight/obese children and adolescents
- False positive troponin result caused by a true macrotroponin
- Letters to the Editor
- Patient safety: patient identification wristband errors
- Prevalence of hemolytic specimens referred for arterial blood gas analysis
- “Triage” of lymphoid malignancies in the peripheral blood using the Extended Immunofluorescent Application of the CELL-DYN Sapphire automated hematology analyzer
- Presepsin (sCD14-ST): development and evaluation of one-step ELISA with a new standard that is similar to the form of presepsin in septic patients
Artikel in diesem Heft
- Editorials
- Laboratory testing and/or monitoring of the new oral anticoagulants/antithrombotics: for and against?
- Circulating macrocomplexes: old wine in new bottles?
- Review
- Laboratory assessment of new anticoagulants
- Minireviews
- Biomarkers in Alzheimer’s disease
- Analytical variability in sport hematology: its importance in an antidoping setting
- The plodding diagnosis of monogenic autoinflammatory diseases in childhood: from the clinical scenery to laboratory investigation
- Opinion Paper
- Collective opinion paper on findings of the 2010 convocation of experts on laboratory quality
- Genetics and Molecular Diagnostics
- Genetic variability of the fructosamine 3-kinase gene in diabetic patients
- Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis
- Performance evaluation of a multiplex assay for future use in biomarker discovery efforts to predict body composition
- Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes
- General Clinical Chemistry and Laboratory Medicine
- Quality Indicators in Laboratory Medicine: from theory to practice
- Implementation of computerized add-on testing for hospitalized patients in a large academic medical center
- Human growth hormone (GH) immunoassay: standardization and clinical implications
- Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology1)
- Trefoil factor family peptides in human saliva and cyclical cervical mucus. Method evaluation and results on healthy individuals
- Steroid binding properties of the 2nd WHO International Standard for sex hormone-binding globulin
- Thyroxin overdose due to rheumatoid factor interferences in thyroid-stimulating hormone assays
- Cancer Diagnostics
- Quantification of HER2 autoantibodies in the amplification phenomenon of HER2 in breast cancer
- Glycosylation of proteins in healthy and neoplastic human salivary glands – a preliminary study
- Infectious Diseases
- Quantification of cerebrospinal fluid lactic acid in the differential diagnosis between HIV chronic meningitis and opportunistic meningitis
- Cardiovascular Diseases
- Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients
- High concentrations of asymmetric dimethylarginine are associated with ST-segment resolution failure after reperfusion for acute myocardial infarction
- An increase in serum uric acid concentrations is associated with an increase in the Framingham risk score in Korean adults
- The effect of a one-year weight reduction program on serum uric acid in overweight/obese children and adolescents
- False positive troponin result caused by a true macrotroponin
- Letters to the Editor
- Patient safety: patient identification wristband errors
- Prevalence of hemolytic specimens referred for arterial blood gas analysis
- “Triage” of lymphoid malignancies in the peripheral blood using the Extended Immunofluorescent Application of the CELL-DYN Sapphire automated hematology analyzer
- Presepsin (sCD14-ST): development and evaluation of one-step ELISA with a new standard that is similar to the form of presepsin in septic patients
