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An increase in serum uric acid concentrations is associated with an increase in the Framingham risk score in Korean adults
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Ga-Eun Nam
Published/Copyright:
February 3, 2011
Abstract
Background: Uric acid is a novel cardiovascular disease (CVD) factor, but its use as an independent risk factor for CVD remains controversial. Here, we examined the correlation between Framingham risk score (FRS) and serum uric acid concentrations in asymptomatic Korean adults.
Methods: This cross-sectional study was performed on 8035 Korean adults. Besides FRS, we measured body mass index, fasting blood glucose, homeostasis model assessment of insulin resistance, creatinine, γ-glutamyltransferase, the lipid profile, uric acid, high-sensitive C-reactive protein, and the white blood cell count. All subjects were placed into one of three risk groups according to their FRS.
Results: All CVD related factors were significantly different in the three FRS groups. The increments of uric acid in-creased significantly FRS from the 10-year risk 0%–9% group to the >10% group after adjusting for other CVD-related factors using ordinal logistic regression analysis. Analyses of the three age groups showed similar effects.
Conclusions: An increased uric acid concentration is associated with an increase in coronary heart disease risk calculated from the FRS, and doctors need to pay attention to this CVD risk in apparently healthy adults with hyperuricemia.
Keywords: cardiovascular disease; coronary heart disease; Framingham risk score; risk factors; uric acid
Received: 2010-8-3
Accepted: 2010-11-21
Published Online: 2011-02-03
Published in Print: 2011-05-01
©2011 by Walter de Gruyter Berlin New York
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Keywords for this article
cardiovascular disease;
coronary heart disease;
Framingham risk score;
risk factors;
uric acid
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- Implementation of computerized add-on testing for hospitalized patients in a large academic medical center
- Human growth hormone (GH) immunoassay: standardization and clinical implications
- Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology1)
- Trefoil factor family peptides in human saliva and cyclical cervical mucus. Method evaluation and results on healthy individuals
- Steroid binding properties of the 2nd WHO International Standard for sex hormone-binding globulin
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