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Association of nucleated red blood cells in blood and arterial oxygen partial tension
-
Sandra Kuert
,
Tim Holland-Letz
Veröffentlicht/Copyright:
1. Dezember 2010
Abstract
Background: Several studies suggest that the detection of nucleated red blood cells (NRBCs) in hospitalized patients indicates an increased risk of mortality. This study evaluates the impact of low arterial oxygen partial tension (pO2) on NRBC appearance and prognosis in NRBC positive patients.
Methods: NRBCs in blood, arterial blood gases, and other laboratory parameters were monitored daily in 234 surgical intensive care patients. pO2 was assessed in relation to mortality and the detection of NRBCs.
Results: NRBCs were found in 67 patients (28.6%). Mortality was significantly higher in NRBC positive patients (41.8%, 28/67) than in those that were NRBC negative (3.0%, 5/167). Multivariate logistic regression showed an increased mortality in NRBC positive patients (odds ratio 5.79; 95% confidence interval (CI) 1.07–31.33, p<0.05). NRBC positive patients showed significantly lower pO2 levels during intensive care treatment than NRBC negative patients. Prior to the initial detection of NRBCs in the peripheral blood, pO2 levels were significantly lower in patients who died than in surviving patients. After the first appearance of NRBCs, no significant difference in pO2 between these groups was found.
Conclusions: The detection of NRBCs is of prognostic significance concerning patient mortality. In NRBC positive patients, hypoxemia occurs more frequently. Low-levels of pO2 seem to precede the appearance of NRBCs, especially in those patients with high risk of mortality.
Received: 2010-3-31
Accepted: 2010-9-24
Published Online: 2010-12-1
Published in Print: 2011-02-01
©2011 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
arterial oxygen partial tension;
mortality;
nucleated red blood cells
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- A novel liquidchip platform for simultaneous detection of 70 alleles of DNA somatic mutations on EGFR, KRAS, BRAF and PIK3CA from formalin-fixed and paraffin-embedded slides containing tumor tissue
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- Serum hepcidin-25 in comparison to biochemical markers and hematological indices for the differentiation of iron-restricted erythropoiesis
- The quality of the extra-analytical phase of laboratory practice in some developing European countries and Mexico – a multicentric study
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