Article
Licensed
Unlicensed
Requires Authentication
Non-infectious conditions and gestational age influence C-reactive protein values in newborns during the first 3 days of life
-
Nora Hofer
,
Wilhelm Müller
Published/Copyright:
December 3, 2010
Abstract
Background: Our aim was to analyze C-reactive protein (CRP) values in term and preterm infants and correlate non-infection-associated increases with various neonatal disorders.
Methods: Retrospective cohort study that included all newborns hospitalized at a tertiary care center between 2004 and 2007 with documented CRP values in the first 3 days of life. Analysis of differences in CRP values between term and preterm newborns and cases with CRP increases in sepsis negative newborns.
Results: For diagnosis of blood culture proven sepsis (19 and 14 cases, respectively) in 353 preterm and 179 term newborns, CRP at a cut-off of 8 mg/L had sensitivities of 53% and 86% and specificities of 91% and 88%, respectively. The area under the receiver operating characteristics curves were 0.799 and 0.890, respectively. Preterm newborns had lower median values compared to term newborns in sepsis positive (9 vs. 18.5 mg/L, p<0.001) and negative newborns (0.5 vs. 2 mg/L, p<0.001). Increases in individuals without infection were correlated significantly with meconium aspiration syndrome and surfactant application in term newborns (p=0.009 and 0.025, respectively) and with surfactant application and higher birth weight in preterm newborns (p<0.001 and 0.031, respectively).
Conclusions: CRP values were significantly lower in preterm compared to term newborns, and its application in the diagnosis of sepsis in preterm newborns was not as reliable as in term newborns. Meconium aspiration syndrome, surfactant application, and high birth weight were associated significantly with increased CRP values.
Keywords: C-reactive protein; meconium aspiration syndrome; neonatal sepsis; surfactant; term and preterm newborn
Received: 2010-4-18
Accepted: 2010-9-15
Published Online: 2010-12-3
Published in Print: 2011-02-01
©2011 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorial
- Hepcidin: the main regulator of iron homeostasis
- Reviews
- Global trends in critical values practices and their harmonization
- Ischemia modified albumin changes – review and clinical implications
- Genetics and Molecular Diagnostics
- Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism
- A novel liquidchip platform for simultaneous detection of 70 alleles of DNA somatic mutations on EGFR, KRAS, BRAF and PIK3CA from formalin-fixed and paraffin-embedded slides containing tumor tissue
- General Clinical Chemistry and Laboratory Medicine
- Mass spectrometry measurement of plasma hepcidin for the prediction of iron overload
- Serum hepcidin-25 in comparison to biochemical markers and hematological indices for the differentiation of iron-restricted erythropoiesis
- The quality of the extra-analytical phase of laboratory practice in some developing European countries and Mexico – a multicentric study
- Impact of cryopreservation on serum concentration of matrix metalloproteinases (MMP)-7, TIMP-1, vascular growth factors (VEGF) and VEGF-R2 in Biobank samples
- Determinants of circulating asymmetric and symmetric dimethylarginines in patients evaluated for acute dyspnea
- Urinary stone composition in pediatric patients: a retrospective study of 205 cases
- Electrolyte-balanced heparin in blood gas syringes can introduce a significant bias in the measurement of positively charged electrolytes
- Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin D3 in serum of infants and adults
- Association of nucleated red blood cells in blood and arterial oxygen partial tension
- Validation and Outcome Studies
- Cystatin C is a reliable marker for estimation of glomerular filtration rate in renal transplantation: validation of a new turbidimetric assay using monospecific sheep antibodies
- Analytical validation of the Liaison Calcitonin_II-Gen (DiaSorin)
- A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP© 250 with the ImmunoCAP© ISAC
- Rapid microwave digestion and microplate reading format method for urinary iodine determination
- Reference Values and Biological Variations
- Serum creatinine concentrations in male and female elite swimmers. Correlation with body mass index and evaluation of estimated glomerular filtration rate
- Biological variation of free β chorionic gonadotropin and pregnancy-associated plasma protein A in first trimester pregnancies
- Non-infectious conditions and gestational age influence C-reactive protein values in newborns during the first 3 days of life
- Cancer Diagnostics
- Interpretation of increments in serial tumour biomarker concentrations depends on the distance of the baseline concentration from the cut-off
- Performance of nuclear matrix protein 22 urine marker and voided urine cytology in the detection of urinary bladder tumors
- High-performance metabolic marker assessment in breast cancer tissue by mass spectrometry
- BRAF analysis by fine needle aspiration biopsy of thyroid nodules improves preoperative identification of papillary thyroid carcinoma and represents a prognostic factor. A mono-institutional experience
- Letters to the Editor
- Stat laboratory timeliness management according to clinician needs
- Stability of serum samples and hemolysis interference on the high sensitivity troponin T assay
- Falsely diminished results for insulin concentrations measured with the IMMULITE® 2000
- Neutrophil gelatinase-associated lipocalin (NGAL) determined in urine with the Abbott Architect or in plasma with the Biosite Triage? The laboratory's point of view
Keywords for this article
C-reactive protein;
meconium aspiration syndrome;
neonatal sepsis;
surfactant;
term and preterm newborn
Articles in the same Issue
- Editorial
- Hepcidin: the main regulator of iron homeostasis
- Reviews
- Global trends in critical values practices and their harmonization
- Ischemia modified albumin changes – review and clinical implications
- Genetics and Molecular Diagnostics
- Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism
- A novel liquidchip platform for simultaneous detection of 70 alleles of DNA somatic mutations on EGFR, KRAS, BRAF and PIK3CA from formalin-fixed and paraffin-embedded slides containing tumor tissue
- General Clinical Chemistry and Laboratory Medicine
- Mass spectrometry measurement of plasma hepcidin for the prediction of iron overload
- Serum hepcidin-25 in comparison to biochemical markers and hematological indices for the differentiation of iron-restricted erythropoiesis
- The quality of the extra-analytical phase of laboratory practice in some developing European countries and Mexico – a multicentric study
- Impact of cryopreservation on serum concentration of matrix metalloproteinases (MMP)-7, TIMP-1, vascular growth factors (VEGF) and VEGF-R2 in Biobank samples
- Determinants of circulating asymmetric and symmetric dimethylarginines in patients evaluated for acute dyspnea
- Urinary stone composition in pediatric patients: a retrospective study of 205 cases
- Electrolyte-balanced heparin in blood gas syringes can introduce a significant bias in the measurement of positively charged electrolytes
- Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin D3 in serum of infants and adults
- Association of nucleated red blood cells in blood and arterial oxygen partial tension
- Validation and Outcome Studies
- Cystatin C is a reliable marker for estimation of glomerular filtration rate in renal transplantation: validation of a new turbidimetric assay using monospecific sheep antibodies
- Analytical validation of the Liaison Calcitonin_II-Gen (DiaSorin)
- A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP© 250 with the ImmunoCAP© ISAC
- Rapid microwave digestion and microplate reading format method for urinary iodine determination
- Reference Values and Biological Variations
- Serum creatinine concentrations in male and female elite swimmers. Correlation with body mass index and evaluation of estimated glomerular filtration rate
- Biological variation of free β chorionic gonadotropin and pregnancy-associated plasma protein A in first trimester pregnancies
- Non-infectious conditions and gestational age influence C-reactive protein values in newborns during the first 3 days of life
- Cancer Diagnostics
- Interpretation of increments in serial tumour biomarker concentrations depends on the distance of the baseline concentration from the cut-off
- Performance of nuclear matrix protein 22 urine marker and voided urine cytology in the detection of urinary bladder tumors
- High-performance metabolic marker assessment in breast cancer tissue by mass spectrometry
- BRAF analysis by fine needle aspiration biopsy of thyroid nodules improves preoperative identification of papillary thyroid carcinoma and represents a prognostic factor. A mono-institutional experience
- Letters to the Editor
- Stat laboratory timeliness management according to clinician needs
- Stability of serum samples and hemolysis interference on the high sensitivity troponin T assay
- Falsely diminished results for insulin concentrations measured with the IMMULITE® 2000
- Neutrophil gelatinase-associated lipocalin (NGAL) determined in urine with the Abbott Architect or in plasma with the Biosite Triage? The laboratory's point of view
