Lactic acid is of low predictive value for the diagnosis of bacterial infection in ventricular cerebrospinal fluid samples containing residual blood
-
Klas Böer
Abstract
Background: Lactic acid concentrations (LA) are an established marker of bacterial infection in cerebrospinal fluid (CSF). However, use of LA for the detection of infection in CSF with residual blood has not been fully evaluated.
Methods: Analysis of LA and total protein, cell count and bacterial culture were performed in 90 lumbar and ventricular CSF samples contaminated with blood.
Results: Bacterial culture was positive in six CSF samples. The diagnostic value of the cell count was significantly higher than that of LA for the prediction of a positive culture, even if all culture positive and all likely infected samples were included in the analysis. There was no significant difference in LA concentrations between positive or likely positive ventricular CSF samples and all negative, ventricular samples.
Conclusions: Although LA concentrations in CSF are evidently a predictor of bacterial infection, its diagnostic value for the detection of bacterial infection in ventricular CSF with residual blood is limited.
Clin Chem Lab Med 2010;48:1777–80.
©2010 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- Editorial
- Biomarkers of cardiovascular risk – matters of prediction and precision
- Reviews
- Inflammatory markers, cholesterol and statins: pathophysiological role and clinical importance
- C-reactive protein and venous thromboembolism: causal or casual association?
- Perspectives
- Statistical methods for assessment of added usefulness of new biomarkers
- Genetics and Molecular Diagnostics
- ThalassoChip, an array mutation and single nucleotide polymorphism detection tool for the diagnosis of β-thalassaemia
- General Clinical Chemistry and Laboratory Medicine
- Glycated hemoglobin vs. the oral glucose tolerance test for the exclusion of impaired glucose tolerance in high-risk individuals
- Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry
- Evaluation of D-dimer in the diagnosis of suspected aortic dissection
- Quantification of coagulation factor XIII activity by a thio-NADH based assay using factor XIII immuno-depleted plasma as a diluent for calibration
- Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing
- Fatty acid composition of serum phospholipids in cystic fibrosis (CF) patients with or without CF related liver disease
- Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources
- Evaluation of the Sysmex UF-1000i® urine flow cytometer in the diagnostic work-up of suspected urinary tract infection in a Dutch general hospital
- Association between coffee consumption and the estimated glomerular filtration rate in the general Japanese population: preliminary data regarding C-reactive protein concentrations
- Lactic acid is of low predictive value for the diagnosis of bacterial infection in ventricular cerebrospinal fluid samples containing residual blood
- Accuracy of the Precision® point-of-care ketone test examined by liquid chromatography tandem-mass spectrometry (LC-MS/MS) in the same fingerstick sample
- Cancer Diagnostics
- Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy
- Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methods
- Determination of biological variation of α-fetoprotein and choriogonadotropin (β chain) in disease-free patients with testicular cancer
- Infectious Diseases
- Investigation of the relationship between apolipoprotein E gene polymorphisms and hepatitis B virus infection in northern China
- Helicobacter pylori infection and the severity of gastritis are not associated with iron deficiency in a group of Brazilian patients
- Cardiovascular Diseases
- Proatrial natriuretic peptide is a better predictor of 28-day mortality in septic shock patients than proendothelin-1
- The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death
- Relationship of hepatic steatosis and alanine aminotransferase with coronary calcification
- Letters to the Editor
- Novel mutation at codon 110 of the human APOE gene: impact on genotyping with fluorescent hybridization probes
- A simple, fast and inexpensive automated technique for measurement of plasma nitrite
- Development of an innovative serological test for detection of antibodies to Treponema pallidum
- Erratum
- Controversies on quotient reporting to standardise laboratory results
- Acknowledgement
- Acknowledgement
Artikel in diesem Heft
- Editorial
- Biomarkers of cardiovascular risk – matters of prediction and precision
- Reviews
- Inflammatory markers, cholesterol and statins: pathophysiological role and clinical importance
- C-reactive protein and venous thromboembolism: causal or casual association?
- Perspectives
- Statistical methods for assessment of added usefulness of new biomarkers
- Genetics and Molecular Diagnostics
- ThalassoChip, an array mutation and single nucleotide polymorphism detection tool for the diagnosis of β-thalassaemia
- General Clinical Chemistry and Laboratory Medicine
- Glycated hemoglobin vs. the oral glucose tolerance test for the exclusion of impaired glucose tolerance in high-risk individuals
- Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry
- Evaluation of D-dimer in the diagnosis of suspected aortic dissection
- Quantification of coagulation factor XIII activity by a thio-NADH based assay using factor XIII immuno-depleted plasma as a diluent for calibration
- Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing
- Fatty acid composition of serum phospholipids in cystic fibrosis (CF) patients with or without CF related liver disease
- Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources
- Evaluation of the Sysmex UF-1000i® urine flow cytometer in the diagnostic work-up of suspected urinary tract infection in a Dutch general hospital
- Association between coffee consumption and the estimated glomerular filtration rate in the general Japanese population: preliminary data regarding C-reactive protein concentrations
- Lactic acid is of low predictive value for the diagnosis of bacterial infection in ventricular cerebrospinal fluid samples containing residual blood
- Accuracy of the Precision® point-of-care ketone test examined by liquid chromatography tandem-mass spectrometry (LC-MS/MS) in the same fingerstick sample
- Cancer Diagnostics
- Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy
- Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methods
- Determination of biological variation of α-fetoprotein and choriogonadotropin (β chain) in disease-free patients with testicular cancer
- Infectious Diseases
- Investigation of the relationship between apolipoprotein E gene polymorphisms and hepatitis B virus infection in northern China
- Helicobacter pylori infection and the severity of gastritis are not associated with iron deficiency in a group of Brazilian patients
- Cardiovascular Diseases
- Proatrial natriuretic peptide is a better predictor of 28-day mortality in septic shock patients than proendothelin-1
- The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death
- Relationship of hepatic steatosis and alanine aminotransferase with coronary calcification
- Letters to the Editor
- Novel mutation at codon 110 of the human APOE gene: impact on genotyping with fluorescent hybridization probes
- A simple, fast and inexpensive automated technique for measurement of plasma nitrite
- Development of an innovative serological test for detection of antibodies to Treponema pallidum
- Erratum
- Controversies on quotient reporting to standardise laboratory results
- Acknowledgement
- Acknowledgement