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Helicobacter pylori infection and the severity of gastritis are not associated with iron deficiency in a group of Brazilian patients

  • Eliana C. Alvarenga , Ciro G. Montes , Fábio Guerrazzi , José M. Zeitune and Helena Z.W. Grotto
Published/Copyright: October 20, 2010
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 48 Issue 12

Abstract

Background:Helicobacter pylori (H. pylori) infection has been associated with iron deficiency anemia. However, results reported in the literature are contradictory. The goal of the present study was to study the possible association between H. pylori infection and iron deficiency in a sample of adults.

Methods: One hundred and fifty individuals were studied (H. pylori-positive n=75; H. pylori-negative n=50). The presence of anemia was determined using red cell indices and reticulocyte hemoglobin content (CHr). Iron status was assessed based on serum iron and ferritin levels. Possible involvement of inflammatory activity in erythropoiesis was investigated by measuring the correlation between C-reactive protein (CRP) and red cell indices and iron status.

Results: There were no significant differences in the hematological or biochemical parameters for the two groups. Iron deficiency was diagnosed in six individuals, but no difference in prevalence was found between the H. pylori-positive and H. pylori-negative groups. A weak but significant inverse correlation was observed between CRP and CHr concentrations and between serum gastrin and CHr in the H. pylori-positive group. These results suggest a reduction in iron availability for reticulocyte hemoglobinization, but insufficient to cause anemia.

Conclusions:H. pylori infection was not a determining factor for development of iron deficiency in our study population.

Clin Chem Lab Med 2010;48:1809–12.

Keywords: C-reactive protein; erythropoiesis; Helicobacter pylori; iron deficiency anemia; iron metabolism; reticulocyte hemoglobin
Corresponding author: Helena Z.W. Grotto, Department of Clinical Pathology, Faculty of Medical Sciences, CP 6111, CEP 13083-970, Campinas, SP, Brazil Fax: +55 19 3521 9434,
Received: 2010-3-2
Accepted: 2010-5-19
Published Online: 2010-10-20
Published in Print: 2010-12-01

©2010 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2010.356
Keywords for this article
C-reactive protein; erythropoiesis; Helicobacter pylori; iron deficiency anemia; iron metabolism; reticulocyte hemoglobin

Articles in the same Issue

  1. Editorial
  2. Biomarkers of cardiovascular risk – matters of prediction and precision
  3. Reviews
  4. Inflammatory markers, cholesterol and statins: pathophysiological role and clinical importance
  5. C-reactive protein and venous thromboembolism: causal or casual association?
  6. Perspectives
  7. Statistical methods for assessment of added usefulness of new biomarkers
  8. Genetics and Molecular Diagnostics
  9. ThalassoChip, an array mutation and single nucleotide polymorphism detection tool for the diagnosis of β-thalassaemia
  10. General Clinical Chemistry and Laboratory Medicine
  11. Glycated hemoglobin vs. the oral glucose tolerance test for the exclusion of impaired glucose tolerance in high-risk individuals
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  13. Evaluation of D-dimer in the diagnosis of suspected aortic dissection
  14. Quantification of coagulation factor XIII activity by a thio-NADH based assay using factor XIII immuno-depleted plasma as a diluent for calibration
  15. Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing
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  17. Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources
  18. Evaluation of the Sysmex UF-1000i® urine flow cytometer in the diagnostic work-up of suspected urinary tract infection in a Dutch general hospital
  19. Association between coffee consumption and the estimated glomerular filtration rate in the general Japanese population: preliminary data regarding C-reactive protein concentrations
  20. Lactic acid is of low predictive value for the diagnosis of bacterial infection in ventricular cerebrospinal fluid samples containing residual blood
  21. Accuracy of the Precision® point-of-care ketone test examined by liquid chromatography tandem-mass spectrometry (LC-MS/MS) in the same fingerstick sample
  22. Cancer Diagnostics
  23. Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy
  24. Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methods
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  26. Infectious Diseases
  27. Investigation of the relationship between apolipoprotein E gene polymorphisms and hepatitis B virus infection in northern China
  28. Helicobacter pylori infection and the severity of gastritis are not associated with iron deficiency in a group of Brazilian patients
  29. Cardiovascular Diseases
  30. Proatrial natriuretic peptide is a better predictor of 28-day mortality in septic shock patients than proendothelin-1
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