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Association between coffee consumption and the estimated glomerular filtration rate in the general Japanese population: preliminary data regarding C-reactive protein concentrations

  • Kazuhiko Kotani , Naoki Sakane , Toshiyuki Yamada and Nobuyuki Taniguchi
Published/Copyright: August 24, 2010
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 48 Issue 12

Abstract

Background: Cardiometabolic disorders including cardiovascular disease (CVD) where the relevance of regular coffee consumption is debatable, has been linked with the development of chronic kidney disease (CKD). A more recent study suggests that coffee consumption is associated with normal or increased kidney function as assessed by the estimated glomerular filtration rate (eGFR). The present study investigated whether the association between coffee and the eGFR was independent of chronic inflammation, and whether adding sugar to coffee could affect the eGFR.

Methods: A total of 114 age- and gender-matched Japanese individuals (females/males=68/46, mean age=59.5 years), without CVD and severe CKD, were studied. Clinical variables, such as body mass index, blood pressure, blood glucose, lipids and high-sensitivity C-reactive protein (hsCRP), in addition to eGFR [the Modification of Diet in Renal Disease (MDRD) study equation], were measured.

Results: Coffee drinkers had higher eGFR values [73.9±16.5 (SD) mL/min/1.73 m2] than non-coffee drinkers (68.6±11.7). The difference remained significant (F=5.04, p=0.027), independently of clinical variables, including hsCRP. The eGFR values among coffee drinkers were similar between the subjects with and without use of sugar.

Conclusions: The association of coffee drinking habits to eGFR may occur independently of inflammation as assessed by hsCRP. The use of sugar may have no effect on GFR. Further research is needed to clarify this phenomenon.

Clin Chem Lab Med 2010;48:1773–6.

Keywords: C-reactive protein; chronic kidney disease; coffee consumption; glomerular filtration rate; sugar intake
Corresponding author: Kazuhiko Kotani, PhD, MD, Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1–1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto 612-8555, Japan Phone: +81-285-58-7386, Fax: +81-285-44-9947,
Received: 2010-1-3
Accepted: 2010-6-18
Published Online: 2010-08-24
Published in Print: 2010-12-01

©2010 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2010.347
Keywords for this article
C-reactive protein; chronic kidney disease; coffee consumption; glomerular filtration rate; sugar intake

Articles in the same Issue

  1. Editorial
  2. Biomarkers of cardiovascular risk – matters of prediction and precision
  3. Reviews
  4. Inflammatory markers, cholesterol and statins: pathophysiological role and clinical importance
  5. C-reactive protein and venous thromboembolism: causal or casual association?
  6. Perspectives
  7. Statistical methods for assessment of added usefulness of new biomarkers
  8. Genetics and Molecular Diagnostics
  9. ThalassoChip, an array mutation and single nucleotide polymorphism detection tool for the diagnosis of β-thalassaemia
  10. General Clinical Chemistry and Laboratory Medicine
  11. Glycated hemoglobin vs. the oral glucose tolerance test for the exclusion of impaired glucose tolerance in high-risk individuals
  12. Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry
  13. Evaluation of D-dimer in the diagnosis of suspected aortic dissection
  14. Quantification of coagulation factor XIII activity by a thio-NADH based assay using factor XIII immuno-depleted plasma as a diluent for calibration
  15. Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing
  16. Fatty acid composition of serum phospholipids in cystic fibrosis (CF) patients with or without CF related liver disease
  17. Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources
  18. Evaluation of the Sysmex UF-1000i® urine flow cytometer in the diagnostic work-up of suspected urinary tract infection in a Dutch general hospital
  19. Association between coffee consumption and the estimated glomerular filtration rate in the general Japanese population: preliminary data regarding C-reactive protein concentrations
  20. Lactic acid is of low predictive value for the diagnosis of bacterial infection in ventricular cerebrospinal fluid samples containing residual blood
  21. Accuracy of the Precision® point-of-care ketone test examined by liquid chromatography tandem-mass spectrometry (LC-MS/MS) in the same fingerstick sample
  22. Cancer Diagnostics
  23. Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy
  24. Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methods
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  26. Infectious Diseases
  27. Investigation of the relationship between apolipoprotein E gene polymorphisms and hepatitis B virus infection in northern China
  28. Helicobacter pylori infection and the severity of gastritis are not associated with iron deficiency in a group of Brazilian patients
  29. Cardiovascular Diseases
  30. Proatrial natriuretic peptide is a better predictor of 28-day mortality in septic shock patients than proendothelin-1
  31. The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: a potential serum marker to evaluate cardiac autonomic control and sudden cardiac death
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  37. Erratum
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