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VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of hepatocellular carcinoma

  • Yibo Wang , Fang Luo , Yi Zheng , Xiaohan Fan , Jinxing Chen , Yu Zhang and Rutai Hui
Published/Copyright: June 25, 2010
Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 48 Issue 10

Abstract

Background: PIVKAII (protein induced by vitamin K absence), used for screening for hepatocellular carcinoma (HCC), is influenced by vitamin K epoxide reductase complex subunit 1 (VKORC1). VKORC1 haplotype frequency is significantly different in ethnic groups. We evaluated whether VKORC1 haplotypes could influence the performance characteristics of PIVKAII in screening for HCC.

Methods: A total 228 HCC patients and 258 patients with hepatitis B were recruited. Tumor size was measured in 76 patients with HCC. Serum PIVKAII concentrations and VKORC1 haplotype were determined in the cohort. Youden's index and ROC curves were used to compare the performance characteristics of PIVKAII in screening for HCC.

Results: In the HCC group and in patients with hepatitis B, serum PIVKAII concentrations were higher in VKORC1 rs2395612 TT carriers than in CC/CT carriers (50.34±72.18 vs. 11.98±27.45, p<0.05 in HCC group and 1.92±0.52 vs. 1.48±0.36, p<0.01). The estimated optimal cut-off value of PIVKAII for screening HCC was 2.0 and 3.0 ng/mL in CC/CT carriers and TT carriers, respectively. Furthermore, VKORC1 haplotypes also influenced the association of serum PIVKAII concentrations with HCC tumor size in patients with HCC.

Conclusions:VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of HCC. Thus, measurement could be complementary for PIVKAII in HCC screening.

Clin Chem Lab Med 2010;48:1475–9.

Keywords: hepatocellular carcinoma; PIVKAII (protein induced by vitamin K absence); VKORC1 haplotype
Corresponding authors: Yibo Wang, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, P.R. China Phone: +86-10-88398154, Fax: +86-10-68331730, Rutai Hui, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, P.R. China Phone: +86-10-68333902, Fax: +86-10-68331730,
Received: 2010-2-2
Accepted: 2010-4-21
Published Online: 2010-06-25
Published in Print: 2010-10-01

©2010 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2010.275
Keywords for this article
hepatocellular carcinoma; PIVKAII (protein induced by vitamin K absence); VKORC1 haplotype

Articles in the same Issue

  1. Editorial
  2. Darwinian evolution or regression? The fate of laboratory professionals
  3. Review
  4. Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis
  5. Minireview
  6. Laboratory diagnostics in acute poisoning: critical overview
  7. Opinion Papers
  8. On the origins of physicians: Darwinian or Lamarckian evolution?
  9. Observed, unknown distributions of clinical chemical quantities should be considered to be log-normal: a proposal
  10. Guidelines and Recommendations
  11. Development and description of GETT: a Genetic testing Evidence Tracking Tool
  12. Genetics and Molecular Diagnostics
  13. DNA sequencing errors in molecular diagnostics of filamin myopathy
  14. High resolution melting for the identification of mutations in the iron responsive element of the ferritin light chain gene
  15. General Clinical Chemistry and Laboratory Medicine
  16. Detection of serum free light chains: the problem with antigen excess
  17. Hepcidin concentrations and iron homeostasis in preeclampsia
  18. Automated assay for non-transferrin-bound iron in serum samples
  19. A simple liquid chromatography-tandem mass spectrometry method for urinary free cortisol analysis: suitable for routine purpose
  20. Evaluation of a multiplex assay for adipokine concentrations in obese children
  21. The use of serial patient blood gas, electrolyte and glucose results to derive biologic variation: a new tool to assess the acceptability of intensive care unit testing
  22. Point-of-care determination of neonatal bilirubin with the blood gas analyzer RapidLab 1265
  23. The effect of pre-analytical variables on light transmittance aggregometry in citrated platelet-rich plasma from healthy subjects
  24. Cancer Diagnostics
  25. Clinical significance of serum macrophage-colony stimulating factor (M-CSF) in esophageal cancer patients and its comparison with classical tumor markers
  26. VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of hepatocellular carcinoma
  27. Serum soluble tumour necrosis factor receptor type I concentrations independently predict prognosis in patients with breast cancer
  28. Variations in systemic biomarkers of oxidative/nitrosative stress and DNA damage before and during the consequent two cycles of chemotherapy in breast cancer patients
  29. Spurious increase in serum chromogranin A: the role of heterophilic antibodies
  30. Infectious Diseases
  31. Identification and evaluation of a new nucleic acid amplification test target for specific detection of Mycobacterium tuberculosis
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  33. Liquid chromatography-tandem mass spectrometry method for simultaneous quantification of four triazole antifungal agents in human plasma
  34. Evaluation of two sirolimus assays using the ARCHITECT-i1000® CMIA or RxL® ACMIA methods in comparison with the IMx® MEIA method
  35. Widespread use of point-of-care testing is irreconcilable with the present-day quest for safety
  36. Congress Abstracts
  37. 3rd Annual Congress of the Austrian Society for Laboratory Medicine and Clinical Chemistry Salzburg, Austria, 27-30 October 2010
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