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Cord blood and maternal serum neopterin concentrations in patients with pre-eclampsia

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Published/Copyright: May 4, 2010
Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 48 Issue 8

Abstract

Background: Pre-eclampsia is a syndrome characterized by hypertension and proteinuria. The aim of this study was to investigate neopterin concentrations in cord blood and maternal serum in patients with pre-eclampsia and a control group.

Methods: Cord blood and maternal serum neopterin were measured in 21 patients with pre-eclampsia and in 27 control subjects. Neopterin concentrations were measured by high performance liquid chromatography.

Results: Cord blood neopterin concentrations were significantly increased in patients with pre-eclampsia compared to controls (54.3±16.8 vs. 43.4±8.5 nmol/L, p=0.011, respectively). Maternal serum neopterin (257.3±36.8 vs. 150.9±33.8 nmol/L, p<0.001) was also higher in patients with pre-eclampsia.

Conclusions: Cord blood and maternal serum neopterin concentrations are higher in patients with pre-eclampsia. Maternal serum neopterin concentrations used may be used as a marker for the early diagnosis of pre-eclampsia.

Clin Chem Lab Med 2010;48:1127–31.

Keywords: cord blood; maternal serum; neopterin; pre-eclampsia
Corresponding author: Halil Yaman, Department of Medical Biochemistry, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey Phone: +90 312 3043319, Fax: +90 312 3043300, ;
Received: 2010-1-7
Accepted: 2010-2-5
Published Online: 2010-05-04
Published in Print: 2010-08-01

©2010 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2010.213
Keywords for this article
cord blood; maternal serum; neopterin; pre-eclampsia

Articles in the same Issue

  1. Editorials
  2. Errors in transfusion medicine are not only misidentifications of the recipient, but also pre-analytical and analytical errors
  3. Biochemical and imaging biomarkers: the search for the Holy Grail
  4. Reviews
  5. Molecular diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: an update of new CYP21A2 mutations
  6. Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins
  7. Minireview
  8. Errors in transfusion: causes and measures to avoid them
  9. Opinion Paper
  10. Improving the harmonisation of the International Normalized Ratio (INR): time to think outside the box?
  11. Genetics and Molecular Diagnostics
  12. Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs
  13. Development and evaluation of an automated hepatitis C virus NS5B sequence-based subtyping assay
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  26. Cancer Diagnostics
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  28. Increased expression of the oncogenic KLF6-SV1 transcript in human glioblastoma
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