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Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fall
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Niklas Mattsson
Veröffentlicht/Copyright:
5. März 2010
Abstract
Several drug candidates for Alzheimer's disease are being evaluated in clinical trials, with the goal of finding a drug with disease-modifying effects. When such a drug finally reaches the market, there will be a demand for accurate diagnostic tools useful for early detection of disease and for monitoring biochemical effects. The core cerebrospinal fluid (CSF) biomarkers amyloid peptides (Aβ42), total-tau and phospo-tau are promising in this respect. However, inter-center variation (caused by pre-analytical, analytical and post-analytical factors), and inter-laboratory variation (caused by analytical factors), particularly for CSF Aβ42, lowers their utility in multicenter studies. Here, we discuss the causes of these variations, and present a global quality control program to overcome them.
Clin Chem Lab Med 2010;48:603–7.
Received: 2009-11-6
Accepted: 2010-1-8
Published Online: 2010-03-5
Published in Print: 2010-05-01
©2010 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
Alzheimer's disease;
amyloid;
cerebrospinal fluid;
quality control;
variations
Artikel in diesem Heft
- Editorials
- Laboratory medicine and natural disasters: are we ready for the challenge?
- Reference values: still a critical issue in laboratory medicine
- Review
- Contemporary platelet function testing
- Minireviews
- Disasters: where they find us
- Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fall
- Opinion Paper
- Glycated hemoglobin (HbA1c): old dogmas, a new perspective?
- Guidelines and Recommendations
- IFCC reference procedures for measurement of the catalytic concentrations of enzymes: corrigendum, notes and useful advice
- Recommendations for the implementation of international standardization of glycated hemoglobin in Italy
- Genetics and Molecular Diagnostics
- UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology
- Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers
- Automated genomic DNA extraction from saliva using the QIAxtractor
- General Clinical Chemistry and Laboratory Medicine
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- Evaluation of the Becton-Dickinson rapid serum tube: does it provide a suitable alternative to lithium heparin plasma tubes?
- Immunoglobulin M antibodies to aquaporin-4 in neuromyelitis optica and related disorders
- Evaluation of the new body fluid mode on the Sysmex XE-5000 for counting leukocytes and erythrocytes in cerebrospinal fluid and other body fluids
- Extracellular haemoglobin, oxidative stress and quality of red blood cells relative to perioperative blood salvage
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- Leptin and adiponectin levels in pubertal children: relationship with anthropometric variables and body composition
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