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Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysis
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Giovanni Targher
Published/Copyright:
September 22, 2009
Abstract
Background: The prevalence of thyroid autoimmunity and subclinical primary hypothyroidism in persons with chronic kidney disease (CKD) not requiring chronic dialysis is not well defined.
Methods: We studied 1000 consecutive adult outpatients who were referred by their general practitioner for blood testing over the last 2 years. We excluded those with abnormal serum free thyroxine (FT4) levels (n=85). No participants required chronic renal replacement therapy. Thyroid autoimmunity was defined as increased concentrations of serum anti-thyroid antibodies. Subclinical primary hypothyroidism was defined as a serum thyrotropin (TSH) concentration >4 mIU/L. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2.
Results: Overall, 53 (5.8%) subjects had eGFR <60 mL/min/1.73 m2. Of these, 98 (10.7%) had subclinical hypothyroidism, and 213 (23.3%) subjects had increased anti-thyroid antibodies. Approximately 26% and 34% of those with eGFR <60 mL/min/1.73 m2 had laboratory evidence of subclinical hypothyroidism or thyroid autoimmunity, respectively. In subgroup analysis stratified by TSH and thyroid autoimmunity, decreasing eGFR values appeared to be more strongly related with the increase in TSH rather than antithyroid antibodies.
Conclusions: Thyroid autoimmunity and subclinical primary hypothyroidism are highly prevalent in persons with CKD not requiring chronic dialysis.
Clin Chem Lab Med 2009;47:1367–71.
Keywords: epidemiology; estimated glomerular filtration rate; subclinical hypothyroidism; thyroid autoimmunity; thyroid dysfunction
Received: 2009-6-4
Accepted: 2009-7-17
Published Online: 2009-09-22
Published in Print: 2009-11-01
©2009 by Walter de Gruyter Berlin New York
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Keywords for this article
epidemiology;
estimated glomerular filtration rate;
subclinical hypothyroidism;
thyroid autoimmunity;
thyroid dysfunction
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- The journal impact factor: navigating between Scylla and Charybdis
- Opinion Papers
- Journal Impact Factor: it will go away soon
- The Journal Impact Factor: don't expect its demise any time soon
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- Discordant total and free prostate-specific antigen (PSA) assays: does calibration with WHO reference materials diminish the problem?
- Molecular diagnostics in acute leukemias
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- Considerations for the development of a reference method for sequencing of haploid DNA – an opinion paper on behalf of the IFCC Committee on Molecular Diagnostics. International Federation of Clinical Chemistry and Laboratory Medicine
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