Haemolysis index – an estimate of preanalytical quality in primary health care
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Johan Söderberg
Abstract
Background: Haemolysis is usually caused by inadequate specimen collection or preanalytical handling, and is suggested to be a suitable indicator of pre-analytical quality. We investigated the prevalence of detectable haemolysis in all routine venous blood samples to identify differences in preanalytical quality.
Methods: Haemolysis index (HI) values were obtained from a Vitros 5,1 in the routine clinical chemistry laboratory for samples collected in primary health care centres (PHCs), nursing homes, and a hospital emergency department (ED). Haemolysis was defined as a HI ≥15 (detection limit).
Results: Samples from the PHC with the highest prevalence of haemolysis were 6.1 times (95% confidence interval (CI) 4.0–9.2) more often haemolysed compared to the centre with the lowest prevalence. Of the samples collected in primary health care, 10.4% were haemolysed compared to 31.1% in the ED (p<0.001). A notable difference in haemolysed samples was found between the ED section staffed by emergency medicine physicians and the section staffed by primary health care physicians (34.8% vs. 11.3%, p<0.001).
Conclusions: The significant variation in haemolysis indices among the investigated units is likely to reflect varying preanalytical conditions. The HI is a valuable tool for estimation and follow-up of preanalytical quality in primary health care.
Clin Chem Lab Med 2009;47:940–4.
©2009 by Walter de Gruyter Berlin New York
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- Editorial
- Hemolysis index: quality indicator or criterion for sample rejection?
- Review
- Neutrophil CD64: a diagnostic marker for infection and sepsis
- Genetics and Molecular Diagnostics
- Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese
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- Heterophile antibodies may falsely increase or decrease thyroglobulin measurement in patients with differentiated thyroid carcinoma
- Variation of barrier permeability for albumin and immunoglobulin G influx into cerebrospinal fluid
- Anti-citrullinated protein antibody and rheumatoid factor in patients with end-stage renal disease
- Reference Values and Biological Variations
- Quality of interpretative commenting on common clinical chemistry results in the Asia-Pacific region and Africa
- Analysis and interpretation of drug testing results from patients on chronic pain therapy: a clinical laboratory perspective
- Cancer Diagnostics
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