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Neutrophil CD64: a diagnostic marker for infection and sepsis
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Johannes J.M.L. Hoffmann
Published/Copyright:
August 1, 2009
Abstract
Neutrophilic granulocytes express Fcγ receptor (FcγR) [cluster of differentiation 64 (CD64) antigen] only when they are activated. Neutrophil CD64, demonstrated using flow cytometry, can be used as a diagnostic marker of infection and sepsis. Neutrophil CD64 is superior to C-reactive protein and hematological determinations for detecting systemic infection or sepsis, since it combines high sensitivity (90% or more) with high specificity (90%–100%) in both adults and children. In addition, the test performs well in distinguishing infection from flares in autoimmune inflammatory diseases and has somewhat more limited utility for differentiating bacterial from viral infection. This review summarizes the available literature regarding CD64 as a marker of infection, and outlines future clinical studies for confirming the diagnostic performance of this promising marker.
Clin Chem Lab Med 2009;47:903–16.
Keywords: cluster of differentiation 64 (CD64); diagnostic tests; Fcγ receptor (FcγR); infection; neutrophils; sensitivity; sepsis; specificity
Received: 2009-3-29
Accepted: 2009-5-25
Published Online: 2009-08-01
Published in Print: 2009-08-01
©2009 by Walter de Gruyter Berlin New York
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Keywords for this article
cluster of differentiation 64 (CD64);
diagnostic tests;
Fcγ receptor (FcγR);
infection;
neutrophils;
sensitivity;
sepsis;
specificity
Articles in the same Issue
- Editorial
- Hemolysis index: quality indicator or criterion for sample rejection?
- Review
- Neutrophil CD64: a diagnostic marker for infection and sepsis
- Genetics and Molecular Diagnostics
- Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese
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- Clinical, biochemical, and genetic analysis of a Korean neonate with hereditary tyrosinemia type 1
- General Clinical Chemistry and Laboratory Medicine
- Multicenter evaluation of the hemolysis index in automated clinical chemistry systems
- Haemolysis index – an estimate of preanalytical quality in primary health care
- Evaluation of the Innovance D-DIMER analytical performance
- Heterophile antibodies may falsely increase or decrease thyroglobulin measurement in patients with differentiated thyroid carcinoma
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- Anti-citrullinated protein antibody and rheumatoid factor in patients with end-stage renal disease
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- Quality of interpretative commenting on common clinical chemistry results in the Asia-Pacific region and Africa
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