Variation of barrier permeability for albumin and immunoglobulin G influx into cerebrospinal fluid
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Sepp Seyfert
Abstract
Background: The aim of the present study was to analyze variations in permeability of albumin and immunoglobulin G (IgG) influx into cerebrospinal fluid (CSF) in a clinical setting.
Methods: In a retrospective intra-individual comparison of CSF samples, we used the IgGIndex and its constituents to indicate alterations in IgG/albumin permeability.
Results: We found altered IgGIndices in 25/64 patients (range –25% to +44%), with differently altered QAlb and QIgG values (–69% to +549%), unaltered IgG-Indices in a further 25/64 patients with equally altered QAlb and QIgG values (–46% to +107%), and no parameter alteration in 14/64 patients. Parameter alterations in 25/64 patients indicated that permeability of albumin was changed to different extents than for IgG. It changed in the same direction in 20/25 patients, and the opposite in five patients. In further 25/64 patients, equal QAlb and QIgG alterations indicated equally altered permeabilities and/or altered efflux of the proteins. In 14/64 patients, no alteration in permeability or efflux was seen.
Conclusions: Results revealed surprisingly variable intra-individual changes in permeabilities for albumin and IgG in pathologic as well as normal CSF. Differing changes in permeability indicate that the diffusion paths of the two proteins may react to disturbances independently of each other. The details of the influx permeability for albumin and IgG into CSF illustrate the prospect of a more comprehensive insight into the protein exchange between blood and CSF.
Clin Chem Lab Med 2009;47:955–8.
©2009 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Editorial
- Hemolysis index: quality indicator or criterion for sample rejection?
- Review
- Neutrophil CD64: a diagnostic marker for infection and sepsis
- Genetics and Molecular Diagnostics
- Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese
- Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia
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- Haemolysis index – an estimate of preanalytical quality in primary health care
- Evaluation of the Innovance D-DIMER analytical performance
- Heterophile antibodies may falsely increase or decrease thyroglobulin measurement in patients with differentiated thyroid carcinoma
- Variation of barrier permeability for albumin and immunoglobulin G influx into cerebrospinal fluid
- Anti-citrullinated protein antibody and rheumatoid factor in patients with end-stage renal disease
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- Quality of interpretative commenting on common clinical chemistry results in the Asia-Pacific region and Africa
- Analysis and interpretation of drug testing results from patients on chronic pain therapy: a clinical laboratory perspective
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- HER1-4 protein concentrations in normal breast tissue from breast cancer patients are expressed by the same profile as in the malignant tissue
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