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Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk?
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Eline Verhoye
Veröffentlicht/Copyright:
22. Dezember 2008
Abstract
Low-density lipoproteins (LDLs) are susceptible to structural modifications by oxidation, particularly the small dense LDL particles. The formation of lipid peroxidation derivates, such as thiobarbituric reactive substances, conjugated dienes, lipid hydroperoxides, and aldehydes, is associated with changes in apolipoprotein conformation and affects the functional properties of LDLs. Oxidized LDL (oxLDL) formation in the subendothelial space of the arterial wall is a key initiating step in atherosclerosis because it contributes to foam cell generation, endothelial dysfunction, and inflammatory processes. In the last decade, immunoassays were developed using monoclonal antibodies against oxidation-dependent epitopes of LDL which made it possible to directly measure oxLDL in the circulation. Increased circulating oxLDL concentrations have been related to cardiovascular disease in some studies, although not always independently after adjustment of classical lipid markers. The Asklepios Study, investigating 2524 healthy middle-aged subjects, showed that circulating oxLDL is affected by many biological and lifestyle factors, as well as (generalized) subclinical atherosclerosis.
Clin Chem Lab Med 2009;47:128–37.
Keywords: apolipoprotein B; atherosclerosis; cardiovascular disease; oxidized low-density lipoprotein (LDL); small dense LDL
Received: 2008-6-20
Accepted: 2008-10-17
Published Online: 2008-12-22
Published in Print: 2009-02-01
©2009 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
apolipoprotein B;
atherosclerosis;
cardiovascular disease;
oxidized low-density lipoprotein (LDL);
small dense LDL
Artikel in diesem Heft
- Editorial
- 50th Anniversary of SBCC/BVKC: “International Symposium Brussels 2008: New Trends in Clinical Biology. Emerging Technologies and their Impact on Laboratory Medicine and Management”
- Reviews
- Vitamin D: current status and perspectives
- Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk?
- New European guidelines for cardiovascular disease prevention in clinical practice
- Review
- Causes, consequences, detection, and prevention of identification errors in laboratory diagnostics
- Genetics and Molecular Diagnostics
- The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan
- Polymorphisms and plasma soluble levels of E-selectin in patients with chronic hepatitis B virus infection
- General Clinical Chemistry and Laboratory Medicine
- Effect of high levels of human chorionic gonadotropin and estradiol on the severity of hyperemesis gravidarum
- Freeze-thaw and matrix effects in direct high-density lipoprotein cholesterol methods
- Methodology for monitoring cytomegalovirus infection after renal transplantation
- High concentrations of haptocorrin interfere with routine measurement of cobalamins in human serum and milk. A problem and its solution
- Reference Values and Biological Variations
- Inter- and intra-individual variations of urinary endogenous metabolites in healthy male college students using 1H NMR spectroscopy
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- Age and hormone replacement therapy as factors influencing androgen levels in the postmenopausal female
- Preheparin serum lipoprotein lipase mass interacts with gender, gene polymorphism and, positively, with smoking
- Validation and Outcome Studies
- Comparison of calcium, magnesium, sodium, potassium, zinc, and creatinine concentration in 24-h and spot urine samples in women
- Performance of free β-human chorionic gonadotrophin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) analysis between Delfia Xpress and AutoDelfia systems in The Netherlands
- A pilot survey of the use and implementation of cardiac markers in acute coronary syndrome and heart failure across Europe The CARdiac MArker Guideline Uptake in Europe (CARMAGUE) study
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- Interference of IgM-λ paraprotein with biuret-type assay for total serum protein quantification
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